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Index
Cover
Table of Contents
Title
Copyright
Preface to the 1st edition
Preface to the 2nd edition
Introduction
Introduction
Early developments
Biotechnology today
Microbiology
Viruses
Bacteriophages
Microorganisms
Bacteria
Yeasts
Fungi
Algae
Some bacteria of importance for biotechnology
Microorganisms: isolation, preservation, safety
Microorganisms: strain improvement
Biochemistry
Biochemistry
Amino acids, peptides, proteins
Enzymes: structure, function, kinetics
Sugars, glycosides, oligo- and polysaccharides
Lipids, membranes, membrane proteins
Metabolism
Genetic engineering
DNA: structure
DNA: function
RNA
Genetic engineering: general steps
Preparation of DNA
Other useful enzymes for DNA manipulation
PCR: general method
PCR: laboratory methods
DNA: synthesis and size determination
DNA sequencing
Transfer of foreign DNA in living cells (transformation)
Gene cloning and identification
Gene expression
Gene silencing
Epigenetics
Gene libraries and gene mapping
Genetic maps of prokaryotes
Genetic maps of eukaryotes
Metagenomics
Cell biology
Cell biology
Stem cells
Blood cells and immune system
Antibodies
Reporter groups
Solid state fermentation (SSF)
Growing microorganisms
Growth kinetics and product formation
Fed-batch, continuous and high cell density fermentation
Fermentation technology
Fermentation technology: scale-up
Cultivation of mammalian cells
Mammalian cell bioreactors
Enzyme and cell reactors
Recovery of bioproducts
Recovery of proteins: chromatography
Economic aspects of industrial processes
Food and food additives
Alcoholic beverages
Beer
Fermented food
Food and lactic acid fermentation
Prebiotics and probiotics
Bakers’ yeast and fodder yeasts
Fodder yeasts from petroleum feedstocks, single cell oil
Amino acids
L-Glutamic acid
D, L-Methionine, L-lysine, and L-threonine
Aspartame™, L-phenylalanine, and L-aspartic acid
Amino acids via enzymatic transformation
Vitamins
Nucleosides and nucleotides
Industrial products
Bio-Ethanol
1-Butanol
Higher alcohols and alkenes
Acetic acid/vinegar
Citric acid
Lactic acid, 3-hydroxy-propionic acid (3-HP)
Gluconic acid and “green” sugar chemicals
Dicarboxylic acids
Biopolymers: Polyesters
Biopolymers: Polyamides
Polysaccharides
Biosurfactants
Fatty acids and their esters
Enzyme technology
Biotransformation
Technical enzymes
Applied enzyme catalysis
Regio- and enantioselective enzymatic synthesis
Enzymes as processing aids
Detergent enzymes
Enzymes for starch hydrolysis
Enzymatic starch hydrolysis
Enzymes and sweeteners
Enzymes for the hydrolysis of cellulose and polyoses
Enzymes in pulp and paper processing
Pectinases
Enzymes and milk products
Enzymes in baking and meat processing
Other enzymes for food products and animal feed
Enzymes in leather and textile treatment
Procedures for obtaining novel technical enzymes
Protein design
Antibiotics
Antibiotics: occurrence, applications, mechanism of action
Antibiotics: screening, industrial production, and mechanism of action
Antibiotic resistance
β-Lactam antibiotics: structure, biosynthesis, and mechanism of action
β-Lactam antibiotics: manufacture.
Amino acid and peptide antibiotics
Glycopeptide, lipopeptide, polyether, and nucleoside anti-biotics
Aminoglycoside antibiotics
Tetracyclines, chinones, chinolones, and other aromatic antibiotics
Macrolide antibiotics
New pathways to antibiotics
Pharmaceuticals and medical technology
Insulin
Growth hormone and other hormones
Hemoglobin, serum albumen, and lactoferrin
Blood clotting agents
Anticoagulants and thrombo-lytic agents
Enzyme inhibitors
Interferons
Interleukins and “anti-interleukins”
Erythropoietin and other growth factors
Other therapeutic proteins
Monoclonal and catalytic antibodies
Recombinant antibodies
Therapeutic antibodies
Vaccines
Recombinant vaccines
Steroid biotransformations
Diagnostic enzymes
Enzyme tests
Biosensors
Immunoanalysis
Glycobiology
Agriculture and environment
Animal breeding
Embryo transfer, cloned animals
Gene maps
Transgenic animals
Breeding, gene pharming and xenotransplantation
Plant breeding
Plant tissue surface culture
Plant cell suspension culture
Transgenic plants: methods
Transgenic plants: resistance
Transgenic plants: products
Aerobic wastewater treatment
Anaerobic wastewater and sludge treatment
Biological treatment of exhaust air
Biological soil treatment
Microbial leaching, biofilms, and biocorrosion
Megatrends
The human genome
Functional analysis of the human genome
Pharmacogenomics, nutrigenomics
DNA assays
Gene therapy
Induced pluripotent stem cells (iPS)
Tissue Engineering
Drug screening
High-throughput sequencing
Proteomics
DNA and protein arrays
Metabolic engineering
Synthetic biology
Systems biology
Bioinformatics: sequence and structural databases
Bioinformatics: functional analyses
Carbon sources (C-sources)
Biorefineries
Safety in genetic engineering
Regulation of products derived from biotechnology
Ethical considerations and acceptance
Patents in biotechnology
International aspects of biotechnology
Further Reading
Index
Picture Credits
End User License Agreement
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