Cell Biology by Bolsover, Stephen R. -- Read -- Imperial Library of Trantor

Index

Cover Title Page Series Page Copyright Preface Chapter 1: Cells and Tissues

Principles of Microscopy Only Two Types of Cell Viruses Origin of Eukaryotic Cells Cell Specialization in Animals Stem Cells and Tissue Replacement The Cell Wall

Chapter 2: Water and Macromolecules

The Chemical Bond: Sharing Electrons Interactions with Water: Solutions Biological Macromolecules Carbohydrates: Candy and Canes Oxidation and Reduction Involve the Movement of Electrons Amino Acids, Polypeptides, and Proteins Lipids Hydrolysis

Chapter 3: Membranes and Organelles

Basic Properties of Cell Membranes Organelles Bounded by Double-Membrane Envelopes Organelles Boundedby Single Membranes

Chapter 4: DNA Structure and The Genetic Code

The Structure of DNA DNA as the Genetic Material Packaging of DNA molecules Into Chromosomes The Genetic Code

Chapter 5: Dna as a Data Storage Medium

DNA Replication Proteins Open Up the DNA Double Helix During Replication Biochemistry of DNA Replication DNA Repair After Replication Gene Structure and Organization in Eukaryotes Gene Nomenclature

Chapter 6: Transcription and the Control of Gene Expression

Structure of RNA RNA Polymerase Gene Notation Bacterial RNA Synthesis Control of Bacterial Gene Expression Eukaryotic RNA Synthesis Control of Eukaryotic Gene Expression

Chapter 7: Recombinant DNA and Genetic Engineering

DNA Cloning Creating the Clone Uses of DNA Clones Ethics of DNA Testing for Inherited Disease

Chapter 8: Manufacturing Protein

Attachment of an Amino Acid to Its tRNA The Ribosome Bacterial Protein Synthesis Eukaryotic Protein Synthesis is a Little More Complex

Chapter 9: Protein Structure

Naming Proteins Polymers of Amino Acids Other Amino Acids are Found in Nature The Three-Dimensional Structures of Proteins Levels of Complexity Prosthetic Groups The Primary Structure Contains All The Information Necessary To Specify Higher-Level Structures

Chapter 10: Intracellular Protein Trafficking

Three Modes of Intracellular Protein Transport Transport to and From The Nucleus Transport Across Membranes Vesicular Trafficking Between Intracellular Compartments

Chapter 11: How Proteins Work

How Proteins Bind Other Molecules Dynamic Protein Structures Enzymes are Protein Catalysts Cofactors and Prosthetic Groups Enzymes can be Regulated

Chapter 12: Energy Trading within the Cell

Cellular Energy Currencies Energy Currencies Are Interconvertible

Chapter 13: Metabolism

The KREBS Cycle: The Central Switching Yard of Metabolism From Glucose to Pyruvate: Glycolysis From Fats to ACETYL-CoA: β Oxidation Amino Acids as Another Source of Metabolic Energy Making Glucose: Gluconeogenesis Making Glycogen: Glycogenesis Making Fatty Acids, Glycerides and Cholesterol Synthesis of Amino Acids Control of Energy Production

Chapter 14: Ions and Voltages

The Potassium Gradient And The Resting Voltage The Chloride Gradient General Properties Of Channels General Properties Of Carriers Electrical Signaling

Chapter 15: Intracellular Signaling

Calcium Cyclic Adenosine Monophosphate Cyclic Guanosine Monophosphate Multiple Messengers Biochemical Signaling Crosstalk—Signaling Pathways Or Signaling Webs?

Chapter 16: Intercellular Communication

Classifying Transmitters And Receptors Rapid Communication: From Nerve Cells To Their Targets Paracrine Transmitters And The Control Of Muscle Blood Supply Chemotaxis Signaling During Development

Chapter 17: Mechanical Molecules

Microtubules Microtubule-Based Motility Microfilaments Intermediate Filaments

Chapter 18: Cell Cycle and the Control of Cell Number in Eukaryotes

Stages of Mitosis Meiosis and Fertilization Control of the Cell Division Cycle Apoptosis

Chapter 19: The Cell Biology of the Immune System

Cells of the Immune System B Cells and Antibodies T Cells Autoimmune Disease

Chapter 20: Case Study: Cystic Fibrosis

Cystic Fibrosis is a Severe Genetic Disease The Fundamental Lesion in Cystic Fibrosis Lies in Chloride Transport Homing in on the CF Gene Cloning the GENE for CF The CFTR Gene Codes for a Chloride Ion Channel Novel Therapies for CF Diagnostic Tests for CF The Future

Appendix Glossary Answers to Review Questions

Theme: Dimensions in Cell Biology Theme: Types of Cell Theme: Some Basic Components of the Eukaryotic Cell Theme: Types of Organic Chemicals Theme: Chemical Groups and Bonds Theme: Acids and Bases Theme: Membranes Theme: Organelles in Eukaryotic Cells Theme: Transport Across Membranes Theme: Mutations Theme: Bases and Amino Acids Theme: Structures Associated with DNA Theme: Synthesis on a DNA Template Theme: DNA Replication Theme: Regions within Eukaryotic Chromosomes Theme: Codes within the Base Sequence Theme: The Control of Transcription Theme: Events that Occur after Transcription in Eukaryotes Theme: A Mammalian Expression Plasmid Theme: Choosing an Oligonucleotide for a Specific Task Theme: Uses of cDNA Clones Theme: Translation Initiation Theme: Translation Elongation and Termination Theme: The Wobble Theme: Amino Acids Theme: Terms Used to Describe Proteins Theme: Specific Binding Partners Theme: The Three Modes of Intracellular Transport Theme: Trafficking Processes Theme: GTPases Theme: Changing the Preferred Shape of a Protein Theme: Enzyme Kinetics Theme: Enzymes Theme: Cell Spaces and Regions in Energy Trading Theme: The Electron Transport Chain and ATP Synthase Theme: Energy Currencies Theme: Reactions and Pathways Theme: Pathways and Enzymes Theme: Metabolism Theme: Cytosolic and Extracellular Concentrations of Important Ions Theme: Pathways for Solute Movement Across the Plasma Membrane Theme: Ion Fluxes in a Nerve Cell Theme: Processes Downstream of Receptor Tyrosine Kinases Theme: Proteins Activated by Nucleotides Theme: Inositol Compounds Theme: Receptors Theme: Transmitters Theme: Synapses Theme: Cytoskeletal Structures Theme: Proteins of the Cytoskeleton Theme: Fueling Movement Theme: Mitosis Theme: Checkpoints in the Cell Cycle Theme: Life and Death Theme: Immune System Cells Theme: The Antibody Heavy Chain Locus Theme: T Cells and Their Interaction with Other Cells Theme: CFTR Mutations Theme: The CFTR as a Permeability Pathway Theme: A Medly of Sentences about CF

Index

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