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Imperial Library
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Index
Cover Page
Title Page
Contents
PREFACE: WHY STRUCTURE
CHAPTER 1: PROTEINS ARE THE BODY'S WORKER MOLECULES
Proteins Are Made From Small Building Blocks
Proteins in All Shapes and Sizes
Computer Graphics Advance Research
Small Errors in Proteins Can Cause Disease
Parts of Some Proteins Fold Into Corkscrews
Mountain Climbing and Computational Modeling
The Problem of Protein Folding
Provocative Proteins
Structural Genomics: From Gene to Structure, and Perhaps Function
The Genetic Code
CHAPTER 2: X-RAY CRYSTALLOGRAPHY: ART MARRIES SCIENCE
Viral Voyages
Crystal Cookery
Calling All Crystals
Student Snapshot: Science Brought One Student From the Coast of Venezuela to the Heart of Texas
Why X-Rays?
Synchrotron Radiation—One of the Brightest Lights on Earth
Peering Into Protein Factories
Scientists Get MAD at the Synchrotron
CHAPTER 3: THE WORLD OF NMR: MAGNETS, RADIO WAVES, AND DETECTIVE WORK
A Slam Dunk for Enzymes
NMR Spectroscopists Use Tailor-Made Proteins
NMR Magic Is in the Magnets
The Many Dimensions of NMR
NMR Tunes in on Radio Waves
Spectroscopists Get NOESY for Structures
The Wiggling World of Proteins
Untangling Protein Folding
Student Snapshot: The Sweetest Puzzle
CHAPTER 4: STRUCTURE-BASED DRUG DESIGN: FROM THE COMPUTER TO THE CLINIC
The Life of an AIDS Virus
Revealing the Target
Structure-Based Drug Design: Blocking the Lock
A Hope for the Future
How HIV Resistance Arises
Homing in on Resistance
Student Snapshot: The Fascination of Infection
Gripping Arthritis Pain
CHAPTER 5: BEYOND DRUG DESIGN
Muscle Contraction
Transcription and Translation
Photosynthesis
Signal Transduction
GLOSSARY
BACKMATTER
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