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SYNOPSIS INTRODUCTION Part I: WHAT WE KNOW (THE PAST) CHAPTER 1: Viva Primordium Key Takeaway: Human beings inherited the gene circuit that made early life forms super survivors. Key Takeaway: The gene circuit that makes us great survivors is also the reason we age. Key Takeaway: Aging is not caused by free-radical damage or mutations in DNA. Key Takeaway: Aging is the loss of analog biological information. CHAPTER 2: The Demented Pianist Key Takeaway: Aging occurs when the epigenetic signalers that respond to cellular damage are overworked. Key Takeaway: Aging can be slowed down and reversed by activating sirtuins. CHAPTER 3: The Blind Epidemic Key Takeaway: Treating one disease at a time does prolongs neither healthspan nor lifespan. Key Takeaway: Aging is the biggest risk factor for all diseases. Part II: WHAT WE’RE LEARNING (THE PRESENT) CHAPTER 4: Longevity Now Key Takeaway: Limit calories to engage the survival circuit. Key Takeaway: Replace animal protein with plant protein to improve your metabolic health markers. Key Takeaway: Do vigorous exercise five times a week to stay younger at the cellular level. Key Takeaway: Expose yourself to cold temperature to stimulate longevity genes. CHAPTER 5: A Better Pill to Swallow Key Takeaway: Compounds that inhibit mTOR, activate AMPK, and increase NAD levels boost health and longevity. CHAPTER 6: Big Steps Ahead Key Takeaway: Drugs and vaccines that target zombie cells show potential to prolong vitality. Key Takeaway: Yamanaka factors can reset the epigenome and reverse cellular age. CHAPTER 7: The Age of Innovation Key Takeaway: Genome sequencing is revolutionizing the future of medicine. Key Takeaway: Biotrackers are key to optimizing health and boosting longevity. PART III: WHERE WE’RE GOING (THE FUTURE) CHAPTER 8: The Shape of Things to Come Key Takeaway: The transition to longer lives will worsen environmental degradation. Key Takeaway: Longer lifespan will mean less social progress and less social security. Key Takeaway: Mankind will renovate in response to a growing population and make the world an even better place. CHAPTER 9: A Path Forward Key Takeaway: Defining aging as a disease will speed up the innovations that will prolong healthy lifespan. EDITORIAL REVIEW BACKGROUND ON DAVID ANDREW SINCLAIR
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