Fishman’s Pulmonary Diseases and Disorders · 5th Edition by Grippi, Michael -- Read -- Imperial Library of Trantor

Index

Title Page Copyright Page Dedication Contents Contributors Preface PART 1: Perspectives

1 Milestones in the History of Pulmonary Medicine

PART 2: Scientific Basis of Lung Function in Health and Disease

SECTION 1 Genetic, Cellular, and Structural Basis of Normal Lung Function

2 Functional Design of the Human Lung for Gas Exchange 3 The Respiratory Muscles 4 Molecular Regulation of Lung Development 5 Pulmonary Surfactant and Disorders of Surfactant Homeostasis 6 Mucociliary Clearance 7 The Genetic Basis of Respiratory Disorders 8 Stem Cells and Respiratory Disease: Prospects for the Future 9 Personalized Pulmonary Medicine

SECTION 2 Physiological Principles of Normal Lung Function

10 Pulmonary Mechanics 11 Control of Ventilation 12 Circadian Rhythms and Sleep Biology 13 Pulmonary Circulation 14 Ventilation, Pulmonary Blood Flow, and Ventilation–Perfusion Relationships 15 Blood-Gas Transport 16 Diffusion, Chemical Reactions, and Diffusing Capacity 17 Acid–Base Balance

SECTION 3 The Lungs in Different Physiological States

18 Respiratory System Response to Exercise in Health 19 Aging of the Respiratory System

SECTION 4 Lung Immunology

20 Innate and Adaptive Immunity in the Lung 21 Lymphocyte- and Macrophage-Mediated Inflammation in the Lung 22 Mast Cells and Eosinophils 23 Leukocyte Accumulation in Pulmonary Disease 24 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency

SECTION 5 Lung Injury and Repair

25 T Lymphocytes in the Lung 26 Chemokines, Adipokines, and Growth Factors in the Lung 27 Redox Signaling and Oxidative Stress in Lung Diseases 28 Fibroblasts in Lung Homeostasis and Disease

PART 3: Symptoms and Signs of Respiratory Disease

SECTION 6 Clinical Approach to the Patient

29 Approach to the Patient with Respiratory Symptoms

SECTION 7 Diagnostic Procedures

30 Modern Approach to Thoracic Imaging Diagnosis 31 Thoracic Ultrasonography 32 Physiologic and Metabolic Study of Pulmonary Disorders Using Conventional Imaging Techniques and Positron Emission Tomography 33 Pulmonary Function Testing 34 Principles and Applications of Cardiopulmonary Exercise Testing 35 Diagnostic Bronchoscopy, Transthoracic Needle Biopsy, and Related Procedures 36 Interventional Bronchoscopy 37 Diagnostic Thoracic Surgical Procedures: Thoracoscopy, VATS, and Thoracotomy 38 Evaluation of Respiratory Impairment and Disability

PART 4: Obstructive Lung Diseases

SECTION 8 Chronic Obstructive Pulmonary Disease

39 Pathology of Chronic Obstructive Pulmonary Disease: Diagnostic Features and Differential Diagnosis 40 Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, Pathogenesis, and α 1-Antitrypsin Deficiency 41 Cigarette Smoking and Smoking Cessation 42 Course and Treatment of Chronic Obstructive Pulmonary Disease 43 Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders

SECTION 9 Asthma

44 The Biology of Asthma 45 Asthma: Epidemiology 46 Asthma: Clinical Presentation and Management 47 Aspirin- and Exercise-Induced Asthma 48 Allergic Bronchopulmonary Aspergillosis (Mycosis) and Severe Asthma with Fungal Sensitivity

SECTION 10 Other Obstructive Disorders

49 Upper Airway Obstruction in Adults 50 Cystic Fibrosis 51 Bronchiolitis 52 Bullous Disease of the Lung 53 Bronchiectasis

PART 5: Interstitial and Inflammatory Lung Diseases

SECTION 11 Immunologic and Interstitial Diseases

54 Interstitial Lung Disease: A Clinical Overview and General Approach 55 Systemic Sarcoidosis 56 Idiopathic Pulmonary Fibrosis 57 Idiopathic Interstitial Pneumonias Other Than Idiopathic Pulmonary Fibrosis 58 Hypersensitivity Pneumonitis 59 Radiation Pneumonitis 60 Pulmonary Manifestations of the Collagen Vascular Diseases 61 Pulmonary Langerhans’ Cell Histiocytosis 62 Pulmonary Lymphangioleiomyomatosis 63 Benign Metastasizing Leiomyoma 64 Depositional Diseases of the Lungs

PART 6: Drug-Induced Lung Diseases

65 Pulmonary Toxicity Related to Chemotherapeutic Agents 66 Drug-Induced Pulmonary Disease Due to Nonchemotherapeutic Agents

PART 7: Other Infiltrative and Airspace Disorders

67 The Lungs in Patients with Inborn Errors of Metabolism 68 Alveolar Hemorrhage Syndromes 69 Aspiration-Related Pulmonary Disorders 70 Pulmonary Alveolar Proteinosis Syndrome 71 The Eosinophilic Pneumonias

PART 8: Disorders of the Pulmonary Circulation

72 Pulmonary Arterial Hypertension 73 Pulmonary Thromboembolic Disease 74 Pulmonary Vasculitis 75 Pulmonary Arteriovenous Malformations

PART 9: Disorders of the Pleural Space

76 Nonmalignant Pleural Effusions 77 Malignant Pleural Effusions 78 Pneumothorax

PART 10: Diseases of the Mediastinum

79 Malignant Mesothelioma and Other Primary Pleural Tumors 80 Nonneoplastic Disorders of the Mediastinum 81 Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies 82 Benign and Malignant Neoplasms of the Mediastinum

PART 11: Disorders of the Chest Wall, Diaphragm, and Spine

83 Nonmuscular Diseases of the Chest Wall 84 Effects of Neuromuscular Diseases on Ventilation 85 Management of Neuromuscular Respiratory Muscle Dysfunction

PART 12: Occupational and Environmental Disorders

SECTION 12 Occupational Disorders

86 Asbestos-Related Lung Disease 87 Chronic Beryllium Disease and Hard-Metal Lung Diseases 88 Coal Workers’ Lung Diseases and Silicosis 89 Occupational Asthma, Byssinosis, and Industrial Bronchitis 90 Acute and Chronic Responses to Toxic Inhalations

SECTION 13 Environmental Disorders

91 Indoor and Outdoor Air Pollution 92 High-Altitude Physiology and Clinical Disorders 93 Diving Injuries and Air Embolism 94 Thermal Lung Injury and Acute Smoke Inhalation

PART 13: Pulmonary Complications of Nonpulmonary Disorders

95 Noninfectious Pulmonary Complications of Hematopoietic Stem Cell and Solid Organ Transplantation 96 Pulmonary Complications of Sickle Cell Disease 97 Pulmonary Disorders and Pregnancy 98 Pulmonary Complications of Intra-abdominal Disease

PART 14: Sleep and Sleep Disorders

99 Sleep Apnea Syndromes: Central and Obstructive 100 Sleep-Related Hypoventilation Syndromes 101 Changes in the Cardiorespiratory System During Sleep 102 Differential Diagnosis and Evaluation of Sleepiness

PART 15: Surgical Aspects of Pulmonary Medicine

103 Perioperative Respiratory Considerations in the Surgical Patient 104 Acute Respiratory Failure in the Surgical Patient 105 Perioperative Care of the Patient Undergoing Lung Resection 106 Thoracic Trauma 107 Lung Transplantation

PART 16: Neoplasms of the Lungs

SECTION 14 Lung Cancer

108 Genetic and Molecular Changes in Lung Cancer: Prospects for a Personalized Pharmacological Approach to Treatment 109 Epidemiology of Lung Cancer 110 Approach to the Patient with Pulmonary Nodules 111 The Pathology of Bronchogenic Carcinoma 112 Clinical Evaluation, Diagnosis, and Staging of Lung Cancer 113 Treatment of Non–Small-Cell Lung Cancer: Surgery 114 Treatment of Non–Small-Cell Lung Cancer: Chemotherapy 115 Treatment of Non–Small-Cell Lung Cancer: Radiation Therapy 116 Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History 117 Primary Lung Tumors Other than Bronchogenic Carcinoma: Benign and Malignant 118 Extrapulmonary Syndromes Associated with Lung Tumors 119 Pulmonary Metastases: The Role of Surgical Resection

SECTION 15 Lymphoproliferative Disorders

120 Lymphoproliferative and Hematologic Diseases Involving the Lung and Pleura

PART 17: Infectious Diseases of the Lungs

SECTION 16 General Concepts

121 Pulmonary Clearance of Infectious Agents 122 Approach to the Patient with Pulmonary Infection 123 Pulmonary Infection in Immunocompromised Hosts 124 Microbial Virulence Factors in Pulmonary Infections 125 Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia

SECTION 17 Common Syndromes in Pulmonary Infectious Diseases

126 Infections of the Upper Respiratory Tract 127 Aspiration, Empyema, Lung Abscesses, and Anaerobic Infections 128 Acute Bronchitis and Community-Acquired Pneumonia 129 Healthcare-Acquired Pneumonia, Including Ventilator-Associated Pneumonia

SECTION 18 Major Pathogens in Pulmonary Infections

130 Viral Infections of the Lung and Respiratory Tract 131 Tuberculosis 132 Diseases due to Nontuberculous Mycobacteria 133 Aspergillus, Candida, and Other Opportunistic Mold Infections of the Lung 134 Cryptococcosis and the Endemic Mycoses 135 Pneumocystis Pneumonia 136 Protozoan Infections of the Thorax 137 Helminthic Diseases of the Lungs 138 Zoonotic and Other Unusual Bacterial Pneumonias

PART 18: Acute Respiratory Failure

139 Respiratory Failure: An Overview SECTION 19 Lung Failure

140 Acute Respiratory Distress Syndrome: Pathogenesis 141 Acute Lung Injury and the Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcomes 142 Sepsis, Multiple Organ Dysfunction Syndrome, and Chronic Critical Illness

SECTION 20 Respiratory Pump Failure

143 Pump Failure: The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease

SECTION 21 Management and Therapeutic Interventions

144 Oxygen Therapy and Toxicity 145 Pulmonary Pharmacotherapy 146 Intubation and Upper Airway Management 147 Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure 148 Principles of Mechanical Ventilation 149 Nutrition in Pulmonary Disease 150 Diagnosis and Treatment of Pain, Agitation, and Delirium in the Intensive Care Unit 151 Early Mobilization of Patients in the ICU 152 Organization of Intensive Care Units and Long-Term Acute Care Hospitals 153 Ethics and Palliative Care in Critical Care Units

APPENDIXES

Appendix A Terms and Symbols in Respiratory Physiology Appendix B Normal Values for a Healthy 20-Year Old Seated Man

Index

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