The Patient Equation, The Precision Medicine Revolution in the Age of COVID-19 and Beyond by Vries, Glen de -- Read -- Imperial Library of Trantor

Index

Cover Table of Contents Introduction

Notes

SECTION 1: From Hippocrates to Epocrates

1 Before We Cured Scurvy

Nanometers to Megameters Scurvy The False Promise of Genotype Your Very Own High-frequency Medical Device Notes

2 Inside the Equations

Like Lions of the Serengeti The Layer Cake Patients Like You, Patients Like Me Changing the Frequency Reverse-engineering the Critical Layers The Cognitive Dimension Better Measurements at Virtually No Cost From Hypothesis Confirmation to Hypothesis Generation Notes

3 Fitbits, Smart Toilets, and a Bluetooth-enabled Self-driving ECG

Are Apps the New Snake Oil? Wearables for Panicked Dogs It's the Equations, Not the Devices Let's Start with the Thermostat Notes

SECTION 2: Applying Data to Disease

Enter Ava The Changing Role of the Patient The Motivation to Comply A Man Who Just Can't Ovulate Finding a Niche in a Crowded Field Notes

Out of the Danger Zone Lowering Barriers to Zero A Perfectly Artificial Pancreas Hacking One's Own Device One Drop at a Time Notes

Catching Sepsis Earlier Partnering with Doctors, Not Replacing Them Looking Beyond Sepsis Using Crowdsourcing to Track the Flu Stopping the Spread of Illness with Data Is Hard Notes

7 Cancer and Phage Therapy—Crafting Custom Treatments Just for You

Changing the Way We Look at Cancer p53-ologists of the Future Or Perhaps Car-t-ographers of the Present Personalized Immunotherapy Beyond Cancer Notes

Finding Clusters in a Random World Dr. David Fajgenbaum's Quest for a Cure Rare Diseases, Common Problems Notes

SECTION 3: Building Your Own Patient Equations

9 The Steam Table

Progressing Toward Alzheimer's Disease…or Maybe Not When the Measurement and the Therapy Are One and the Same Steam Tables for Cancer The Data Problem From Wellness to Illness—and Back Again Notes

10 Good Data

The Failure of Watson The Mars Climate Orbiter The Progression to Value Notes

11 Changing Clinical Trials

Expanding Access to Trials Pharma's Lack of Connection to Clinical Care Truly Patient-centric Trials Accepting New Kinds of Data Unshackling the Clinical Trial Enter Thomas Bayes Breaking the Barrier Synthetic Control Arms Our Synthetic Control Model Making Every Trial an Adaptive Trial A Stroke of Insight Notes

12 Disease Management Platforms

The Promise of Mobile Apps Digital from the Beginning But It's Not That Easy Where That Leaves Us Notes

SECTION 4: Scaling Progress to the World

13 The Importance of Collaboration

A Tiny Island or a Larger Ecosystem How Data Collaboration Can Change the Game Notes

14 Value-based Reimbursement

Beyond Survival The (Mathematical) Fountain of Youth Money-back Guarantee Making Value-based Care the Future Notes

15 Aligning Incentives

Human Doctors, Digital Doctors Respecting the Unquantifiable Empowered Patients Notes

16 And Then, a Pandemic

Phase Diagrams Revisited Steam Tables, Sensors, and Early Warning Systems Putting a Spotlight on the Fragility of Our System A Speedier Road to Modernized Trial Design The Next Hundred Years Notes

Conclusion

Privacy and Transparency So What's Next? Notes

Acknowledgments About the Authors

Glen de Vries Jeremy Blachman

Index End User License Agreement