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Index
Cover
Frontmatter
1. Bone Toxicology in Preclinical Drug Testing
1. Introduction and Considerations in Bone Toxicology
2. Bone Physiology and Biology
3. Specific Considerations for Bone Evaluations for Pediatric Therapeutics
4. Animal Models in Bone Research
2. Methods in Bone Research
5. Biochemical Markers of Bone Turnover
6. Skeletal Imaging
7. Biomechanics
8. Application of Histopathology and Bone Histomorphometry for Understanding Test Article-Related Bone Changes and Assessing Potential Bone Liabilities
3. Bone as an Endocrine Organ
9. Bone and Muscle
10. Pituitary Hormone-Driven Mechanism for Skeletal Loss
11. Kidney–Bone: Interaction
12. Bone and the Immune System
13. Bone and the Central Nervous System
14. Intestinal Microbiota and Bone Health: The Role of Prebiotics, Probiotics, and Diet
15. Bone and Energy Metabolism
Backmatter
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