INDEX

A

active genes 76, 80

Aldrich, Robert Anderson 108

alkaptonuria 96

alleles 14, 16, 62

Altmann, Richard 20, 40

Ames, Bruce 68

amino acids 14

apoptosis 116

Asperger, Hans 110

ATP 34, 40

autism 96, 102, 110

autoimmunity 96

autosomes 38, 96, 116

Avery, Oswald, Jr. 20

B

base excision repair (BER) 54

Bateson, William 56, 107

behavioural genetics 102

Bermuda Principles 30

Blackburn, Elizabeth 46

Botstein, David 132

Boveri, Theodor 72, 112

Boyer, Herbert 146

brain synapses 96

Brenner, Sydney 118

Bunker, Chang & Eng 92

Bütschli, Johann 50

C

cancer 112

and HPV 97

Carroll, Sean B. 100

Cattanach, Bruce 80

Cech, Thomas 60

Celera Genomics 30, 145

cell cycle 48

cell division 50

cell nuclei 36

cell reprogramming 150

central dogma 28

centromeres 34, 46

Charpentier, Emmaneulle 152

checkpoint proteins 34, 48

chromatids 34, 38

chromatin 34, 38, 86

chromosomes 14, 38, 116

see also X/Y chromosomes

circadian rhythms 96, 102

cloning 148

codons 14, 24

Cohen, Stanley 146

Collins, Francis 30, 122, 140, 145

computational modelling 136

Coyne, Jerry 18

Crick, Francis 22, 27, 28

CRISPR-Cas9 136, 152

cystic fibrosis 116

cytokinesis 34

cytoplasm 34

cytosine 82, 126

D

Darwin, Charles 18

developmental genetics 100

discordance 76

DNA 14, 20

damage & repair 70

double helix 14, 22

methylation 76, 82

sequencing 117, 126, 145

DNA markers 116

DNA microarrays 116

DNA polymerase 116

Dobzhansky, Theodosius 18

double helix 14, 22

Doudna, Jennifer 152

Dulbecco, Renato 70

E

Ehrman, Lee 102

enzymes 76

epigenetics 76, 89

epigenome 76, 86

eukaryotes 34, 38, 77

evolution, theory of 18, 68

exons 54, 60

expressed sequence tags (EST) 136, 145

F

feedback loops 117

Feinberg, Andrew Paul 82

Fire, Andrew Z. 90

Flemming, Walther 38, 86

Fontana, Felice 36

Franklin, Rosalind 22, 26

G

Galton, Francis 92, 102

gametes 14, 50, 98

Gamow, George 24

Garrod, Archibald 106

genes 14, 56

active/silent 76, 80

environment of 78

expression 64

gene dosage 77

gene therapy 138

imprinting 80

splicing 55, 60

see also Hox genes

genetic code 24

genetic diseases 104

genetic fingerprinting 120

genetic maps 124

genetic testing 122

genetically modified organisms (GMOs) 146

genome 14, 72

editing 152

genome-wide association studies (GWAS) 102, 132

genomics, personalized 140

genotoxic chemicals 54

genotype 54, 62

germ cells 54, 136

Gilbert, Walter 126

Good, Robert A. 108

Gosling, Raymond 26

Greider, Carol 46

Griffith, Frederick 20

Gurdon, John 148, 150

Guthrie, Robert 78, 122

H

Hartwell, Leland 48

Hausen, Harald Zur 112

heamoglobin 96

Hertwig, Oscar 50

histones 34, 38, 86

Holliday, Robin 82

Hox genes 97, 100

Human Genome Project 30, 140, 145

I

ideograms 38

immunity 97

immunodeficiency 97, 108, 138

induced pluripotent stem cells (iPSC) 136, 150

International SNP Map Working Group, The 124

introns 54, 60

J

Jacob, François 129

Jaenisch, Rudolf 146

Jeffreys, Sir Alec 120

Johannsen, Wilhelm 56, 62

jumping genes (transposons) 55, 58, 67

K

Kanner, Leo 110

karyotypes 38

Kennedy, Eugene 40

kinetochore 35, 46

Knudson, Alfred George 112

Kornberg, Arthur 130

Kornberg, Roger 64

Kossel, Albrecht 86

L

Lander, Eric 132

Leduc, Stéphane 142

Leeuwenhoek, Antonie van 36

Lehninger, Albert 40

lentiviral vectors 136

Levene, Phoebus 20

Lindahl, Tomas 70

Lwoff, André 129

lymphocytes 97

Lyon, Mary 84

M

MacLeod, Colin 20

McCarty, Maclyn 20

McClintock, Barbara 58, 66

McClung, Clarence 42, 84, 98

McKusick, Victor 104

meiosis 35, 50

Mello, Craig C. 90

Mendel, Gregor 16, 124

Mendelian traits 104, 107

Mering, Jacques 27

messenger RNA (mRNA) 28, 54, 60, 129

metagenomics 136, 145

methylation 76, 82

Miescher, Johannes Friedrich 20

mitochondria 35, 40

mitosis 35, 50

model organisms 118

Monod, Jacques 64, 128

Morgan, Thomas Hunt 45, 56, 104, 118, 124

Muller, Hermann 68, 70

Mullis, Kary 130

mutation 15, 24, 40, 68, 112

N

Nägeli, Karl von 38

Naldini, Luigi 138

natural selection 55

Neufeld, Peter 120

Nirenberg, Marshall W. 24

non-coding RNA 90

nuclear envelope 36

nuclear matrix 35

nuclear pores 35, 36

nucleases 136, 152

nuclei 36

nucleosomes 77, 86

nucleotides 15, 22, 126

Nurse, Paul Maxime 48, 118

Nüsslein-Volhard, Christiane 100

O

oncogenicity 137

Online Mendelian Index of Man (OMIM) 97

oocytes 137

organelles 35

Osler, Sir William 107

P

personalized genomics 140

phenotype 55, 62

phenylketonuria (PKU) 78

pluripotent cells 137

polymerase chain reaction (PCR) 130, 148

polymers 15, 22

polymorphisms 68

pronucleus 77

purines 77

pyrimidines 77

R

Rabl, Carl 72

recombination frequency 117, 124

replication 15, 28

reverse genetics 118

RNA 15, 24, 28

non-coding 90

see also messenger RNA

Roberts, Richard 60

S

Sanger, Frederick 126

Scheck, Barry 120

sex, determination of 42, 98

Sharp, Phillip 60

shelterin 35

silencing 55

silent genes 76, 80

single-nucleotide polymorphisms (SNPs) 97, 117, 124, 132

Sleeping Beauty transposon system 55, 58

Solter, Davor 80

somatic cells 55

species 15

splicing 55, 60

stem cells 137, 150

Sturtevant, Alfred 124

Surani, Azim 80, 82

synthetic biology 142

Szostak, Jack 46

T

TALEN 137, 152

telomeres 35, 46

Temin, Howard 28

Tilghman, Shirley M. 90

transcription 15, 28

transgenic organisms 137, 146

translation 15, 28

transposons (jumping genes) 55, 58, 67

twins 62, 92, 102, 148

V

vectors 138

Venter, J. Craig 30, 140, 144

viruses 137, 138

Vries, Hugo de 16

W

Waddington, Conrad 76, 88

Waldeyer-Hartz, Heinrich von 38

Wallace, Alfred Russel 18

Watson, James 22, 27, 30

Weismann, August 98

Wilkins, Maurice 22, 27

Wilmut, Ian 148

Woese, Carl Richard 90

Wright, Sewall 68

X

X chromosomes 42, 77, 84

Y

Y chromosomes 42, 77

Yamanaka, Shinya 150

Z

Zhang, Feng 152