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Index
Cover
Title page
Copyright page
Dedication
Table of Contents
Foreword
Preface
Acknowledgments
I Dissecting God’s Megaphone
1 Dissecting God’s Megaphone: The Search for a Pain Gene
2 Sherrington’s Enchanted Loom and Huxley’s Science Fiction
II Chasing Men on Fire: The Search
3 Alabama to Beijing … and Back
Electrophysiological Properties of Mutant NaV1.7 Sodium Channels in a Painful Inherited Neuropathy
Gain-of-Function Mutation in NaV1.7 in Familial Erythromelalgia Induces Bursting of Sensory Neurons
4 Avalanche
The NaV1.7 Sodium Channel: From Molecule to Man
5 Two Sides of One Coin
A Single Sodium Channel Mutation Produces Hyper- or Hypoexcitability in Different Types of Neurons
6 Eavesdropping
Dynamic-Clamp Analysis of Wild-Type Human NaV1.7 and Erythromelalgia Mutant Channel L858H
III Beyond the Search: Expanding Horizons
7 Twisted Nerve: A Ganglion Gone Awry
Multiple Sodium Channel Isoforms and Mitogen-Activated Protein Kinases Are Present in Painful Human Neuromas
8 Crossing Borders
9 From Zebras to Horses
Gain of Function NaV1.7 Mutations in Idiopathic Small Fiber Neuropathy
Neuropathy-Associated NaV1.7 Variant I228M Impairs Integrity of Dorsal Root Ganglion Neuron Axons
10 Ripples
IV Muting God’s Megaphone: From the Squid toward the Clinic
11 Seven Years from Theory toward Therapy … via “Pain in a Dish”
Pharmacological Reversal of a Pain Phenotype in iPSC-Derived Sensory Neurons and Patients with Inherited Erythromelalgia
12 From Trial-and-Error to First-Time-Around: Toward Genomically Guided Therapy
Structural Modelling and Mutant Cycle Analysis Predict Pharmacoresponsiveness of a NaV1.7 Mutant Channel
13 Precision
Pharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling
14 “The Important Thing Is Not to Stop”
Glossary
Index
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