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Index
Cover
Series Page
Title Page
Copyright
Contributors
Foreword
Chapter 1: Applied Anatomy of the Prostate
The basic anatomy
Lymphovascular supply
Zonal anatomy
Neuroanatomy
Chapter 2: Pathology of Prostate Cancer
Introduction
Morphology of prostate cancer
Prognostic factors in prostate cancer
Role of the needle biopsy in the management of prostate cancer
Chapter 3: Biology of Prostate Cancer
Introduction
Genetic factors
Environmental factors
Conclusion
Further reading
Chapter 4: Prostate Cancer Diagnosis
Presentation
The value of a digital rectal examination (DRE)
The use of imaging for diagnosis of prostate cancer
Novel approaches to diagnosis of prostate cancer
Chapter 5: Imaging of Prostate Cancer
Introduction
Plain imaging
Trans-rectal ultrasound (TRUS)
Computed tomography (CT)
Magnetic resonance imaging (MRI)
Radionuclide bone scintigraphy (bone scan)
Potential or future imaging modalities
Chapter 6: Screening for Prostate Cancer
Introduction
Principles of screening
Future developments
Conclusion
Chapter 7: Active Surveillance
Introduction
What is active surveillance?
Why is active surveillance an option in prostate cancer?
What is the difference between active surveillance and watchful waiting?
How is active surveillance undertaken?
What is the evidence for active surveillance?
For which patients is active surveillance an option?
Benefits of active surveillance
Potential risks of active surveillance
When to identify that the disease has progressed?
Future directions
Conclusion
Further reading
Chapter 8: Open Radical Prostatectomy
Introduction
Indications
Surgical technique
Complications
Chapter 9: Laparoscopic Radical Prostatectomy
Introduction
Advantages of laparoscopy
History of laparoscopic radical prostatectomy
Patient selection
Operative details Position
Training
Cost
Conclusion
Chapter 10: Robotic Radical Prostatectomy
Introduction
Robotic technology
Surgical approach and technique
Outcomes data
Controversies
Chapter 11: Prostate Brachytherapy
Introduction
Chapter 12: HIFU
Introduction
History of HIFU
Physical principles of HIFU
Platforms and procedure
Indications
Contra-indications
Summary of published results
Future applications
Chapter 13: Cryotherapy for Prostate Cancer
Introduction
The development of cryosurgery for prostate cancer
Mechanism of tissue injury in prostate cryotherapy
Patient groups amenable to total cryosurgical ablation of the prostate primary therapy—organ-confined disease
Primary therapy—locally advanced disease
Salvage therapy after external beam radiotherapy or brachytherapy
Patient selection for primary cryotherapy
Patient selection for salvage cryotherapy after EBRT or brachytherapy
Technique of cryosurgical ablation of the prostate
Primary cryotherapy of the prostate
Complications of primary cryotherapy of the prostate
Oncological results of salvage cryotherapy series
Complications of salvage cryotherapy series
Focal nerve-sparing primary cryotherapy
Chapter 14: Advances in External Beam Radiotherapy
Introduction
Advances in target localisation: image-guided radiotherapy (IGRT)
Advances in radiotherapy delivery
Chapter 15: Recent Advances in Hormonal Therapy
Introduction
Mode of action
Advanced prostate cancer
Neoadjuvant and adjuvant hormonal therapy
Side-effects of hormonal therapy
Conclusion
Chapter 16: Management of Castration-Resistant Prostate Cancer
Introduction
Conclusion
Chapter 17: Immunology of Prostate Cancer
Prostate cancer and the immune system
The concept of immunoediting
Factors that cause immunosuppression in prostate cancer
Immunotherapy strategies
Conventional treatment and immunology
Clinical trials in prostate cancer immunotherapy
Conclusion
Chapter 18: New Approaches to Prostate Cancer
New approaches to prostate cancer
New treatments for localised prostate cancer
New treatments for metastatic prostate cancer
Index
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