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Index
Instructions for online access
Title page
Table of Contents
Dedication
Copyright
Contributors
Preface
Acknowledgements
1. Introduction and homeostasis
CHAPTER 2 BIOCHEMISTRY AND CELL BIOLOGY
CHAPTER 3 ENERGY METABOLISM
CHAPTER 4 PHARMACOLOGY
CHAPTER 5 HUMAN GENETICS
CHAPTER 6 PATHOLOGY AND IMMUNOLOGY
CHAPTER 7 EPIDEMIOLOGY
SYSTEMS OF THE BODY
CHAPTER 16 DIET AND NUTRITION
HOMEOSTASIS
2. Biochemistry and cell biology
PRINCIPLES OF MOLECULAR INTERACTIONS
CHEMICAL COMPOSITION OF THE HUMAN BODY
THE CELL
3. Energy metabolism
INTRODUCTION TO METABOLISM
CARBOHYDRATE METABOLISM
AMINO ACID METABOLISM
LIPID METABOLISM (Clinical box 3.19)
4. Pharmacology
INTRODUCTION
PHARMACOKINETICS
PHARMACODYNAMICS
Adenylate cyclase and cAMP
Guanylate cyclase, cGMP and nitric oxide (NO)
Phosphodiesterase inhibition
Nitric oxide
Inositol phosphates
DAG
THE AUTONOMIC NERVOUS SYSTEM
5. Human genetics
INTRODUCTION
THE HUMAN GENOME
HUMAN GENETIC VARIATION
MODES OF INHERITANCE
POLYGENIC OR COMPLEX DISEASE
CANCER GENETICS
IDENTIFYING DISEASE GENES
GENETIC DISEASE, DIAGNOSIS AND THERAPY
6. Pathology and immunology
INTRODUCTION
INFECTION
IMMUNITY
NEOPLASIA
7. Epidemiology: science for the art of medicine
INTRODUCTION
THE EPIDEMIOLOGICAL APPROACH
EPIDEMIOLOGICAL ENQUIRY
INVESTIGATION BY REVIEW
HEALTH EDUCATION AND PROMOTION
8. The nervous system
INTRODUCTION
EMBRYOLOGY
GROSS ANATOMY
THE VENTRICULAR SYSTEM
CELLS OF THE NERVOUS SYSTEM
BLOOD SUPPLY TO THE BRAIN AND BRAIN METABOLISM
TRANSMISSION OF NEURAL SIGNALS
MOTOR CONTROL AND PATHWAYS
SENSORY SYSTEMS
SPECIAL SENSES
CENTRAL AUTONOMIC NETWORKS
CONSCIOUSNESS
SLEEP AND WAKEFULNESS
EMOTION
MOTIVATION AND GOAL-DIRECTED BEHAVIOURS
HIGHER CORTICAL FUNCTIONS
BRAIN DEATH
9. Bone, muscle, skin and connective tissue
INTRODUCTION
THE SKELETAL SYSTEM
JOINTS
SKELETAL MUSCLE
POSTURE AND LOCOMOTION
SPECIALISED CONNECTIVE TISSUES: SKIN, HAIR AND NAILS
GENERALISED CONNECTIVE TISSUE
10. Endocrinology
INTRODUCTION
THE ENDOCRINE SYSTEM
NEUROENDOCRINOLOGY
ENDOCRINE HOMEOSTASIS
REPRODUCTIVE PHYSIOLOGY
11. The cardiovascular system
INTRODUCTION
CLINICAL ANATOMY OF THE CARDIOVASCULAR SYSTEM
EMBRYOLOGY
CELLULAR STRUCTURE AND FUNCTION OF THE HEART
BLOOD VESSELS
SYSTEMIC ARTERIAL BLOOD PRESSURE
12. Haematology
THE HAEMOPOIETIC SYSTEM
RED CELLS
ONCOGENESIS AND DISORDERS OF BLOOD CELL PRODUCTION
HAEMOSTASIS AND THROMBOSIS
BLOOD GROUPS AND TRANSFUSION MEDICINE
13. The respiratory system
INTRODUCTION
EPIDEMIOLOGY OF RESPIRATORY DISEASE AND ITS SOCIAL IMPACT
CLASSIFICATION OF COMMON RESPIRATORY DISEASES
ANATOMY OF THE RESPIRATORY SYSTEM
MECHANICS OF BREATHING
PRINCIPLES OF GAS EXCHANGE
CARRIAGE OF OXYGEN BY THE BLOOD
CARRIAGE OF CARBON DIOXIDE BY THE BLOOD
MATCHING LUNG VENTILATION TO LUNG PERFUSION
CONTROL OF BREATHING
ENERGY PRODUCTION AND OXYGEN CONSUMPTION
CHALLENGES TO NORMAL RESPIRATION
RESPIRATORY FAILURE
LUNG DEFENCES AGAINST INFECTION
DEVELOPMENT OF THE LUNGS AND CHANGES IN THE NEWBORN
14. The renal system
INTRODUCTION
ANATOMY OF THE KIDNEY
DEVELOPMENT OF THE KIDNEY
RENAL FUNCTION
THE URINARY TRACT
RENAL DISEASES
15. The alimentary system
INTRODUCTION
OVERVIEW OF DIGESTION AND ABSORPTION
SURFACE ANATOMY OF THE ABDOMEN
MICROANATOMY OF THE GASTROINTESTINAL TRACT
MOUTH
SALIVARY GLANDS
PHARYNX AND OESOPHAGUS
STOMACH AND DUODENUM
CONTROL OF GASTRIC SECRETIONS
GASTRIC MOTILITY
EXOCRINE PANCREAS
THE LIVER AND BILIARY SYSTEM
SMALL INTESTINE
LARGE INTESTINE
16. Diet and nutrition
INTRODUCTION
DIET
NUTRITIONAL STATUS
MICRONUTRIENTS AND WATER
THE CONTROL OF FOOD INTAKE
Index
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