Biology and Diseases of the Ferret by Fox, James G. -- Read -- Imperial Library of Trantor

Index

Cover Title page Copyright page Dedication Contributors

Content Reviewers

Preface I: Biology and Husbandry

1: Taxonomy, History, and Use

Taxonomy Origin Morphology Uses Ferreting Ferret-Legging Transporters Pet Ferrets and Their Status Fur Production Biomedical Research References

2: Anatomy of the Ferret

Superficial Anatomy Skeleton Axial Skeleton Appendicular Skeleton Muscles The Digestive System Respiratory System Heart, Main Vessels, and Associated Structures Urogenital Apparatus Acknowledgments References

3: Neuroanatomy of the Ferret Brain with Focus on the Cerebral Cortex

Introduction Overview Development of the Cerebral Cortex Visual System Auditory System Somatosensory System Multisensory Cortical Areas Motor/Premotor Cortical Areas Summary References

4: Physiology of the Ferret

Cardiovascular Physiology Respiratory System Eustachian Tube Function Gastrointestinal Tract Blood Serum Chemistry Nervous System Autonomic Nervous System Endocrine System Urinary System Acknowledgments References

5: Nutrition of the Ferret

Introduction Gastrointestinal Anatomy and Physiology of the Ferret Types and Forms of Diets for Ferrets Dietary Nutrients Dietary Imbalances or Toxicities Summary Acknowledgments References

6: Housing and Management

A Historical Perspective Housing in Breeding Farms Housing in a Research Setting Bathing Management References

7: Normal Clinical and Biological Parameters

Biological Data Used in Clinical Evaluation Immune Response Hematology and Serum Chemistry von Willebrand Factor Coagulation Parameters Lack of Detectable Blood Groups Drug Metabolism Thyroid and Adrenal Gland Parameters Sex Hormones Urinalysis Estimation of Glomerular Function Rate and Evaluation of Renal Function Electrocardiographic Findings Selected Ophthalmic Parameters Ferret Cell Lines Semen Studies Testosterone References

8: Growth and Reproduction

General Growth and Development Characteristics Reproduction Housing and Breeding Strategies Factors Impacting Reproductive Performance Specific Pathogen-Free and Gnotobiotic Ferrets References

9: Regulatory Considerations

Introduction California Hawaii Puerto Rico US Cities International Rabies Prophylaxis and Management of Bites to and by Ferrets Transportation Acknowledgment References

10: Recovery of the Black-Footed Ferret

Natural History Reproductive Biology Reproductive Management Techniques Preconditioning and Reintroduction Current Issues Influencing Species Recovery Recovery Update References

II: Diseases and Clinical Applications

11: Physical Examination, Preventive Medicine, and Diagnosis in the Ferret

Quarantine and Conditioning Drug and Fluid Administration Oral Dosing Bleeding Techniques Indwelling Catheters Blood Transfusion Bone Marrow Aspiration/Biopsy Endotracheal Intubation Peritoneal Macrophage Harvest Urea Breath Test Gastroscopy Urinary Bladder Catheterization Cerebrospinal Fluid (CSF) Collection Imaging Acknowledgment References

12: Anesthesia

Introduction Preanesthetic Considerations Techniques for Intravenous Catheterization and Drug Administrations Endotracheal Intubation Preanesthetic Medication Neuromuscular Blocking Agents Anesthetic Induction and Maintenance Use of Ventilators in Ferrets Anesthetic Monitoring Techniques Pain Assessment and Management Recovery from Anesthesia Prolonged Anesthesia Neonatal Anesthesia Acknowledgment References

13: Surgery

Presurgical Considerations Instrumentation and Patient Preparation Abdominal Surgery Gastrointestinal (GI) Surgery Hepatobiliary Surgery Urogenital Sterilization Ovariohysterectomy Castration Anal Sacculectomy Surgery of the Endocrine System Splenectomy Musculoskelatal Trauma and Disease Fracture Stabilization Techniques Elbow Luxation Amputation Ferrets as Surgical Models Stereotaxic Surgery for Craniotomy References

14: Diseases of the Hematopoietic System

Introduction Lymphoma Mycosis Fungoides Myeloma Leukemia Anemia Other Disorders of the Hematopoietic System Acknowledgments References

15: Diseases of the Genitourinary System

Diseases of the Jill Acknowledgments References

16: Diseases of the Gastrointestinal System

Introduction Oral Cavity Esophagus Gastric Diseases Hepatobiliary System Miscellaneous Diseases References

17: Diseases of the Endocrine System

Adrenal-Associated Endocrinopathy Other Adrenal Tumors Insulin-Secreting Pancreatic Islet Cell Tumor Diabetes Mellitus Pancreatic Polypeptidoma Thyroid and Parathyroid Diseases References

18: Diseases of the Cardiovascular System

Introduction Other Diagnostic Tests Cardiac Therapeutics for Ferrets Summary References

19: Other Systemic Diseases

Central Nervous System Diseases of the Eye Lymphoma Musculoskeletal System Cardiovascular System Respiratory System Infectious Diseases Systemic Toxicosis References

20: Viral Diseases of Ferrets

Canine Distemper Virus Ferret Coronaviruses Aleutian Disease Virus Influenza Viruses Ferret Rotaviruses Rabies Virus Pseudorabies Bovine Herpesvirus 1 Feline Parvovirus Ferret Papillomavirus SARS Henipaviruses Respiratory Syncytial Virus Vesicular Stomatitis Virus Retrovirus Hepatitis E Virus Transmissible Spongiform Encephalopathies References

21: Bacterial and Mycoplasmal Diseases

Abscesses Actinomycosis Bacterial Pneumonia Botulism Campylobacteriosis Chlamydia Clostridium perfringens Type A Colibacillosis and Colisepticemia Corynebacterium Helicobacter mustelae Leptospirosis Listeriosis Mycobacteriosis Myocplasmosis Proliferative Bowel Disease Salmonellosis Yersinia pestis References

22: Parasitic Diseases

Protozoa Helminths Arthropods References

23: Mycotic Diseases

Systemic Fungal Infections References

24: Neoplastic Diseases

Introduction Endocrine System Hemolymphatic System Integumentary System Digestive System Reproductive System Musculoskeletal System Cardiovascular System Nervous System Urinary System Tumors of the Respiratory System, Mediastinum, and Serosal Membranes Experimental Neoplasms References

III: Research and Applications

25: The Ferret in Viral Respiratory Disease Research

Introduction Techniques for Ferret Respiratory Virus Research Influenza SARS Paramyxoviruses Acknowledgments References

26: The Ferret in Morbillivirus Research

Introduction Morbillivirus Biology Course of CDV Disease in Ferrets Innate and Adaptive Host Responses Transmission Studies Vaccines and Immunization Schedules Vaccination Strategies for Highly Susceptible Species Vaccination in the Context of Pregnancy and Maternal Immunity Vaccine Development Antiviral Therapies Pathogenesis Morbillivirus Immunosuppression Neuroinvasion and CNS Persistence Ferrets as Model for SSPE Pathogenesis Perspectives References

27: Use of the Ferret in Cardiovascular Research

Cardiac Striated Muscle Arrhythmias Vascular Smooth Muscle Acknowledgment References

28: Genetic Engineering in the Ferret

Assisted Reproductive Technologies for Ferrets In Vivo Ferret Oocyte Maturation, Fertilization, and Preimplantation Embryo Development Genetic Engineering in the Ferret Phenotype of CFTR-Knockout Ferrets Summary Acknowledgments References

29: Hearing and Auditory Function in Ferrets

Behavioral Studies of Hearing in Ferrets Organization of the Auditory System Physiological Studies of Auditory Processing in Ferrets Development and Plasticity of the Auditory System Dynamic Neural Coding and Plasticity in the Adult Brain Cochlear Implant Model Concluding Remarks Acknowledgments References

30: The Ferret as a Model for Visual System Development and Plasticity

General Layout and Development of the Ferret Visual System Developmental Timeline of the Ferret Visual System The Ferret Retina Wiring of Retinotopic Pathways Optic Tract and Optic Chiasm Eye-Specific Layers in the LGN On–Off Sublayers in the LGN Geniculocortical Pathway and Ocular-Dominance Columns in Visual Cortex Formation and Maintenance of Feature Maps in Visual Cortex Intrinsic Mechanisms in Visual System Development: Spontaneous Activity and Retinal Waves Ocular-Dominance Plasticity in Visual Cortex Rewiring Cortex: Induction of Visual Inputs to the Auditory Pathway Conclusions Acknowledgments References

31: The Ferret in Nausea and Vomiting Research: Lessons in Translation of Basic Science to the Clinic

Introduction Why the Ferret? The Physiology and Pharmacology of Emesis in the Ferret Translation from the Laboratory to the Clinic Refinement and Optimization of the Ferret Model The Future of the Ferret Emesis Model Acknowledgments and Disclaimer Notes References

32: The Ferret in Lung Carcinogenesis and Nutritional Chemoprevention Research

Introduction The Ferret as a Unique, Nonrodent Model for Studying Smoke-Induced Lung Lesions The Ferret as a Useful Model for Studying Metabolism and Biologic Activity of Carotenoids in Humans Summary Acknowledgments References

Index End User License Agreement

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