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Index
Title Page
Table of Contents
PREFACE
PART ONE - THE HISTORY OF A DISEASE
INTRODUCTION - REVEALING THE MYTH OF ALZHEIMER’S
THE MYTH OF ALZHEIMER’S
MY STORY
THE STORY OF FRANK AND FRAN
THE WISDOM OF FRANK AND FRAN
THE ROLE OF SCIENCE IN THE NEW STORY OF BRAIN AGING
WRITING THE NEW STORY OF BRAIN AGING
CHAPTER ONE - A GATEWAY TO THE FUTURE OF OLD AGE
THE MEDIA AND ALZHEIMER’S
RESISTING THE MEDICALIZATION OF BRAIN AGING
MEDICALIZATION
LESSONS FROM THE EAST
THE POWER OF CHOICE
MY DEMOCRATIC APPROACH TO AGING
STORY—THE INSTRUMENT OF CHANGE
CHANGING THE STORY
WHY WE NEED TO ACT NOW
CAN A BRAIN-AGING FRAMEWORK TRULY PREVAIL?
THE WISDOM OF OPRAH: A LOOK BACK AND WAY FORWARD
ACCEPTING THE LIMITS OF SCIENCE
THE POWER OF STORIES: A NARRATIVE APPROACH TO ENDING ALZHEIMER’S
CHAPTER TWO - ALZHEIMER’S 101: TAMING THE SCIENTIFIC STORY OF AD
ALZHEIMER’S 101
AN INTRODUCTION TO MEMORY
CLASSIFYING MEMORY
THE MAINSTREAM MYTH OF AD
PLAQUES AND TANGLES
THE BAPTIST THEORY
PROBLEMS WITH THE AMYLOID CASCADE HYPOTHESIS
THE TAUIST STORY
THE TRUTH ABOUT PLAQUES AND TANGLES
MOVING PAST PLAQUES AND TANGLES
THE ANTIOXIDANT HYPOTHESIS
THE INFLAMMATORY HYPOTHESIS
THE EXCITATORY CELL DEATH HYPOTHESIS
THE INFECTIOUS DISEASE HYPOTHESIS
THE VASCULAR HYPOTHESIS
THE ALZHEIMER’S-DIABETES HYPOTHESIS
THE AD DIAGNOSIS: A CLINICAL QUANDARY
A DISEASE OF EXCLUSION
CHAPTER THREE - THE TROUBLING LEGACY OF DR. ALOIS ALZHEIMER AND AUGUSTE D.
PORTRAIT OF A YOUNG DOCTOR
MEETING AUGUSTE D.
TRACKING THE CASE
EMIL KRAEPELIN: AN IMPORTANT CRAFTSMAN OF THE AD MYTH
“ON A PECULIAR, SEVERE DISEASE PROCESS …”
THE BIRTH OF THE LABEL
PICK’S LAB: FANNING THE COMPETITIVE FIRES
THE FREUDIAN SCHOOL: DUELING DIAGNOSES
LIFE AND DEATH AFTER AD
CHAPTER FOUR - THE BIRTH OF THE ALZHEIMER’S EMPIRE
TECHNOLOGY AND THE RESURGENCE OF ALZHEIMER’S
THE RISE OF AN EPIDEMIC
ALZHEIMER’S BECOMES A NATIONAL INSTITUTION
ALZHEIMER’S GOES TO WASHINGTON
A “CAUSE CELEBRITY”
DIGGING DEEPER INTO THE DOMINANT METAPHORS OF ALZHEIMER’S DISEASE
WHO BENEFITS FROM THIS AGGRESSIVE MEDICALIZATION OF BRAIN AGING?
THE LIMITS OF OUR INVESTMENTS
THE “WAR ON PERSONHOOD”
MOVING FORWARD WITH THE WISDOM OF T. S. ELIOT
PART TWO - SCIENCE AND TREATMENT
CHAPTER FIVE - WAITING FOR GODOT: ALZHEIMER’S TREATMENTS PAST AND PRESENT
CHOLINESTERASE INHIBITORS: JUST HOW GOOD ARE THEY?
GETTING A READ ON THE DRUGS AVAILABLE TODAY
THE NEW DRUG ON THE BLOCK
IS THERE HOPE FOR FUTURE CHOLINERGIC DRUGS?
CHOOSING PILLS OR NOT
QUALITY OF LIFE AND HOW THE PHARMACEUTICAL INDUSTRY CAN HELP
EVALUATING “BREAKTHROUGHS”
CONTEMPLATING COMPLEMENTARY AND ALTERNATIVE TREATMENTS
INTEGRATING CAM INTO WESTERN CARE
AN INTERVENTION YOU NEEDN’T SWALLOW: VOLUNTEERING AT THE INTERGENERATIONAL SCHOOL
CHAPTER SIX - A BRAVE NEW WORLD OF GENETICS AND MOLECULAR MEDICINE?
GENETICS 101
THE GENETICS OF AD
GETTING TESTED FOR APOE
MY EXPERIENCE IN GENETIC COUNSELING
THE DEPERSONALIZATION OF PERSONAL MEDICINE
MORE LESSONS FROM MY PATIENT’S STORY
GENETIC TREATMENTS FOR AD: WHAT DOES THE FUTURE HOLD?
GETTING TO THE ROOT OF STEM CELLS
NERVE GROWTH FACTOR (NGF) FIBROBLASTS
AMYLOID VACCINE: THE OTHER GREAT HOPE
ALZHEMED: THE AMYLOID DREDGING APPROACH
XALIPRODENE
FLURIZAN
THE PHARMACEUTICAL INDUSTRY
THE NEED FOR A DEEP BIOETHICS
THE POWER OF STORIES
PART THREE - A NEW MODEL FOR LIVING WITH BRAIN AGING
CHAPTER SEVEN - IDENTIFYING WHO NEEDS A PRESCRIPTION FOR MEMORY LOSS
ASSESSING MEMORY CHALLENGES IN YOUR FAMILY
WHEN YOU SEE WARNING SIGNS
CONSIDERING THE DIFFERENTIAL DIAGNOSES OF BRAIN AGING
WHAT YOU SHOULD YOU DO IF YOUR LOVED ONE RESISTS YOUR SUGGESTION TO SEEK MEDICAL HELP FOR MEMORY LOSS
KNOWING THE TERRITORY OF THE BRAIN
A REASON TO BE OPTIMISTIC ABOUT AGING
CHAPTER EIGHT - PREPARING FOR A DOCTOR’S VISIT
FINDING THE RIGHT HEALTH TEAM
YOUR DOCTOR’S APPOINTMENT
THE DOCTOR-PATIENT RELATIONSHIP IN THE TWENTY-FIRST CENTURY
WHAT TO EXPECT ON YOUR FIRST VISIT
FACING THE WORST-CASE SCENARIO
CAN THE HEALTH-CARE SYSTEM COPE WITH NUANCE?
A STORY FROM MY CLINIC
HANDLING SIGNIFICANT CHANGES
THE WEB IS YOUR FRIEND: EVALUATING WHAT THE DOCTOR TELLS YOU USING THE INTERNET
CHAPTER NINE - A PRESCRIPTION FOR SUCCESSFUL AGING ACROSS YOUR LIFE SPAN
HUMAN ECOLOGY: A NEW APPROACH TO PREVENTION
“LET THY FOOD BE THY MEDICINE”: CAN BETTER NUTRITION KEEP US VITAL?
“THE LOOKING-PAST SELF”: KEEPING AN EYE OUT FOR OUR LOVED ONES
A RACE FOR PREVENTION: THE VIRTUES OF EXERCISE
AVOIDING ENVIRONMENTAL EXPOSURES
STRESS-FREE IS THE WAY TO BE
BEYOND CROSSWORD PUZZLES: BUILDING UP A COGNITIVE RESERVE
MAKING A PROFESSION OUT OF PREVENTION
JOINING THE GLOBAL FIGHT AGAINST INFECTIONS
PREVENTION IS KEY
EPILOGUE - THINKING LIKE A MOUNTAIN: THE FUTURE OF AGING
AUTHORS’ NOTE
ACKNOWLEDGMENTS
APPENDIX
NOTES
INDEX
ABOUT THE AUTHORS
Copyright Page
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