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Index
Cover image
Title page
Table of Contents
Copyright
List of Contributors
1: Self-assembling biomaterials: Beginnings, recent progress, and the future
Part One: Molecular building blocks
2: Designing self-assembling biomaterials with controlled mechanical and biological performance
Abstract
2.1 Introduction
2.2 Molecular design
2.3 Applications in biology
2.4 Conclusion and future trends
3: Self-assembling hydrogels from reverse-engineered silk
Abstract
3.1 Introduction
3.2 Silk structure-function relationships
3.3 Reverse engineering the silk cocoon
3.4 Rationale for using self-assembling silk hydrogels for biomedical applications
3.5 Self-assembling silk hydrogels and their applications
3.6 Conclusion and future trends
Acknowledgments
4: Elastin-like proteins: Molecular design for self-assembling
Abstract
4.1 Introduction
4.2 Coacervates
4.3 Nanoparticles
4.4 Hybrid elastin-like recombinamer nanoparticles
4.5 Self-assembly into fibrillar structures
4.6 Self-assembled hydrogels
4.7 Other structures
4.8 Conclusion and future trends
5: Sweet building blocks for self-assembling biomaterials with molecular recognition
Abstract
5.1 Introduction
5.2 Supramolecular systems using unmodified sugars
5.3 Supramolecular systems with glycopolymers and carbohydrate amphiphiles
5.4 Systems responsive to targeted external stimuli
5.5 Conclusion and future trends
6: Peptoid self-assembly and opportunities for creating protein-mimetic biomaterials and biointerfaces
Abstract
6.1 Introduction
6.2 “Conventional” peptoid secondary and tertiary structures
6.3 Therapeutic and diagnostic applications
6.4 Peptoid biointerfaces and self-assembled materials
6.5 Enzymatic recognition and biocompatibility of peptoids
6.6 Conclusion and future trends
7: Lipid bolaamphiphiles for fabricating membrane-mimetic biomaterials
Abstract
7.1 Introduction
7.2 Different classes of bolaamphiphiles
7.3 Biomimetic membranes
7.4 Translocation across vesicle membranes, membrane dynamics, flip-flop
7.5 Self-assembly of bolaamphiphiles into nanostructures
7.6 Structural analysis and experimental techniques for characterizing bolaamphiphiles
7.7 Conception of some original bolaamphiphiles
7.8 Applications of bolaamphiphiles in recognition, encapsulation, drug, and gene delivery
7.9 Conclusion and future trends
8: DNA-based materials as self-assembling scaffolds for interfacing with cells
Abstract
Acknowledgments
8.1 Introduction
8.2 Three-dimensional hydrogels
8.3 Functional two-dimensional surfaces
8.4 Conclusion and future trends
9: Supramolecular biomaterials based on ureidopyrimidinone and benzene-1,3,5-tricarboxamide moieties
Abstract
9.1 Introduction
9.2 Solid biomaterials based on ureidopyrimidinone moieties
9.3 Supramolecular hydrogels
9.4 Supramolecular fibers in solution
9.5 Conclusion and future trends
10: Self-assembled biomaterials using host-guest interactions
Abstract
10.1 Introduction to host-guest interactions
10.2 Building biomaterials with host-guest interactions
10.3 Applications
10.4 Conclusion and future trends
Part Two: Nanostructure in time and space
11: Unique properties of supramolecular biomaterials through nonequilibrium self-assembly
Abstract
11.1 Introduction
11.2 The free energy landscapes of self-assembly
11.3 In-equilibrium self-assembly
11.4 Nondissipative nonequilibrium self-assembly: Metastable assemblies and kinetic traps
11.5 Dissipative nonequilibrium assembly
11.6 Conclusion and future trends
12: Unveiling complex structure and dynamics in supramolecular biomaterials using super-resolution microscopy
Abstract
12.1 Super resolution microscopy for biomaterials
12.2 Why super resolution microscopy for self-assembling biomaterials?
12.3 Polypeptides fibrillar assemblies
12.4 Supramolecular fibers and hydrogels
12.5 Block copolymers & polymer nanoparticles
12.6 Deoxyribonucleic acid (DNA) origami
12.7 Liposomes and lipidic assemblies
12.8 Conclusion and future trends
13: Probing local molecular properties of self-assembled systems with electron paramagnetic resonance (EPR)
Abstract
13.1 Introduction
13.2 Principles of electron paramagnetic resonance spectroscopy
13.3 Dynamics measurements by electron paramagnetic resonance
13.4 Measurement of electrostatic properties
13.5 Perspective on the future of electron paramagnetic resonance for self-assembly
14: Using small-angle X-ray scattering (SAXS) to study the structure of self-assembling biomaterials
Abstract
14.1 General description of small angle scattering techniques
14.2 Analysis of small-angle X-ray scattering data
14.3 Conclusion and future trends
15: Molecular simulation of self-assembly
Abstract
15.1 Introduction
15.2 The molecular dynamics method
15.3 Simulations of molecular self-assembly
15.4 Conclusion and future trends
Part Three: Driving forces and boundaries
16: Magnetic fields to align natural and synthetic fibers
Abstract
16.1 Introduction
16.2 Magnetism
16.3 Diamagnetism
16.4 Alignment of natural fibers
16.5 Applications of aligned protein fibers
16.6 Alignment of peptide based fibers
16.7 Alignment of synthetic polymers
16.8 Conclusion and future trends
17: Displaying biofunctionality on materials through templated self-assembly
Abstract
Acknowledgments
17.1 Introduction
17.2 Surface-induced self-assembly
17.3 Applications of templated self-assembly in biomaterials engineering
17.4 Conclusion and future trends
18: Multicomponent self-assembly: Supramolecular design of complex hydrogels for biomedical applications
Abstract
18.1 Introduction
18.2 Principles of multicomponent self-assembly and hydrogelation
18.3 Advantages of multicomponent hydrogels over single-molecule hydrogels
18.4 Prediction of multicomponent self-assemblies and forces driving them
18.5 Molecular design of multicomponent self-assembling hydrogels
18.6 Conclusion and future trends
19: Enzyme-mediated self-assembly
Abstract
19.1 Introduction
19.2 Enzyme-mediated self-assembly in vitro
19.3 Enzyme-mediated self-assembly in vivo
19.4 Conclusion and future trends
Part Four: Applications
20: Recreating stem-cell niches using self-assembling biomaterials
Abstract
20.1 Introduction
20.2 Stem-cell niches in the body
20.3 General principles for creating biomaterials mimics of extracellular matrix
20.4 Basic design principles of self-assembling peptide and protein materials
20.5 Self-assembling peptides and proteins as regulatory microenvironment for stem cells
20.6 Conclusion and future trends
21: Self-assembled peptide nanostructures and their gels for regenerative medicine applications
Abstract
21.1 Introduction
21.2 Physical and chemical properties of the extracellular matrix
21.3 Conclusion and future trends
22: Functionalization of self-assembling peptides for neural tissue engineering
Abstract
22.1 Introduction
22.2 Self-assembling of functionalized peptides: Design principles and pitfalls
22.3 Biomimetics and mechanical properties functionalized-self-assembling peptides scaffolds
22.4 Screening of functional motifs via phage display libraries and protein docking analysis
22.5 Progresses and opportunities for applications in tissue engineering
22.6 Conclusion and future trends
23: Self-assembling biomaterials as nanocarriers for the targeted delivery of drugs for cancer
Abstract
23.1 Introduction
23.2 Nanostructures that target key receptors/transporters
23.3 Miscellaneous
23.4 Conclusion and future trends
24: Self-assembling biomaterials for theranostic applications
Abstract
24.1 Introduction
24.2 Diagnostics and imaging modalities
24.3 Current theranostic applications
24.4 Conclusion and future trends
25: Single-chain polymeric nanoparticles: Toward in vivo imaging and catalysis in complex media
Abstract
25.1 Introduction
25.2 Collapsing/folding single polymer chains into single chain polymeric nanoparticles
25.3 Controlling intramolecular versus intermolecular assembly/crosslinking processes to obtain polymer nanoparticles
25.4 Compatibility of folded/collapsed amphiphilic polymer nanoparticles with complex cellular environments
25.5 Applying folded/collapsed single-chain polymeric nanoparticles in imaging and diagnostics
25.6 Applying folded/collapsed amphiphilic polymer nanoparticles as drug delivery systems and for photodynamic therapy systems
25.7 Applying folded/collapsed amphiphilic polymer nanoparticles in bio-orthogonal chemistry and catalysis
25.8 Conclusion and future trends
Index
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