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Index
Cover
Title page
Copyright page
Preface
The curse of detail
New features
Obstacles to learning
Learning outcomes
Acknowledgements
About the companion website
Section 1: Groundwork
Chapter 1 The excitement of developmental biology
Where the subject came from
Impact of developmental biology
Future impact
Chapter 2 How development works
Ultrashort summary
Gametogenesis
Early development
Morphogenetic processes
Growth and death
Chapter 3 Approaches to development: developmental genetics
Developmental mutants
Sex chromosomes
Maternal and zygotic
Genetic pathways
Genetic mosaics
Screening for mutants
Cloning of genes
Gain- and loss-of-function experiments
Gene duplication
Limitations of developmental genetics
Chapter 4 Approaches to development: experimental embryology
Normal development
Developmental commitment
Criteria for proof
Chapter 5 Approaches to development: cell and molecular biology techniques
Microscopy
Study of gene expression by molecular biology methods
Study of gene expression by in situ methods
Microinjection
Cell-labeling methods
Section 2: Major model organisms
Chapter 6 Model organisms
The big six
Access and micromanipulation
Genetics and genome maps
Relevance and tempo
Other organisms
Chapter 7 Xenopus
Oogenesis, maturation, and fertilization
Normal development
Experimental methods
Processes of regional specification
Inductive interactions
Chapter 8 The zebrafish
Normal development
Genetics
Embryological and molecular techniques
Regional specification
Other uses for the zebrafish
Chapter 9 The chick
Normal development
Regional specification of the early embryo
Description of organogenesis in the chick
Chapter 10 The mouse
Mammalian fertilization
Normal development
Regional specification
Human early development
Mouse developmental genetics
Other topics in mouse development
Chapter 11 Drosophila
Insects
Normal development
Drosophila developmental genetics
The developmental program
Chapter 12 Caenorhabditis elegans
Adult anatomy
Embryonic development
Analysis of postembryonic development
Section 3: Organogenesis
Chapter 13 Techniques for studying organogenesis and postnatal development
Genetics
Clonal analysis
Tissue and organ culture
Cell separation methods
Chapter 14 Development of the nervous system
Overall structure and cell types
Anteroposterior patterning of the neural plate
Dorsoventral patterning of the neural tube
Neurogenesis and gliogenesis
The neural crest
Development of neuronal connectivity
Chapter 15 Development of mesodermal organs
Somitogenesis and myogenesis
The kidney
Germ cell and gonadal development
Limb development
Blood and blood vessels
The heart
Chapter 16 Development of endodermal organs
Normal development
Experimental analysis of endoderm development
The pancreas
Chapter 17 Drosophila imaginal discs
Metamorphosis
Disc development
Section 4: Growth, regeneration, evolution
Chapter 18 Tissue organization and stem cells
Types of tissue
Tissue renewal
Stem cells
Chapter 19 Growth, aging, and cancer
Growth: control of size and proportion
Aging
Cancer
Chapter 20 Regeneration of missing parts
Distribution of regenerative capacity
Planarian regeneration
Insect limb regeneration
Vertebrate limb regeneration
General properties of regeneration
Chapter 21 Applications of pluripotent stem cells
Cell transplantation therapy
Embryonic stem cells
Personalized pluripotent stem cells
Proposed cell transplantation therapies using pluripotent stem cells
Chapter 22 Evolution and development
Macroevolution
The primordial animal
What really happened in evolution?
Appendix: Key molecular components
Genes
Transcription factor families
Signaling systems
Inducing factor families
Cytoskeleton
Cell adhesion molecules
Extracellular matrix components
Glossary
Index
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