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Index
COVER PAGE
TITLE PAGE
COPYRIGHT PAGE
CONTENTS
PREFACE
CONTRIBUTORS
SECTION I: INTRODUCTION TO BASIC NEUROSCIENCE
1. OVERVIEW OF BRAIN DEVELOPMENT
2. NEUROCHEMICAL SYSTEMS IN THE CENTRAL NERVOUS SYSTEM
3. PRINCIPLES OF ELECTROPHYSIOLOGY
4. PRINCIPLES OF SIGNAL TRANSDUCTION
5. SYNAPTIC AND NEURAL PLASTICITY
6. PRINCIPLES OF MOLECULAR BIOLOGY
7. EPIGENETICS OF PSYCHIATRIC DISEASES
SECTION II: NEW METHODS AND NEW TECHNOLOGIES FOR PRECLINICAL AND CLINICAL NEUROBIOLOGY
8. TRANSGENIC TOOLS AND ANIMAL MODELS OF MENTAL ILLNESS
9. APPLICATION OF STEM CELLS TO UNDERSTANDING PSYCHIATRIC DISORDERS
10. OPTOGENETIC TECHNOLOGIES FOR PSYCHIATRIC DISEASE RESEARCH: CURRENT STATUS AND CHALLENGES
11. BLOOD–BRAIN BARRIER OPENING AND DRUG DELIVERY USING FOCUSED ULTRASOUND AND MICROBUBBLES
12. GENETIC METHODOLOGIES AND APPLICATIONS
13. THE BRAIN AND ITS EPIGENOME
14. NETWORK METHODS FOR ELUCIDATING THE COMPLEXITY OF COMMON HUMAN DISEASES
15. BRAIN IMAGING METHODOLOGIES
16. IMAGE-GUIDED BRAIN STIMULATION
SECTION III: PSYCHOTIC DISORDERS
17. DIAGNOSIS OF THE PSYCHOSES
18. GENETICS OF SCHIZOPHRENIA AND BIPOLAR DISORDER
19. GENOMIC SYNDROMES IN SCHIZOPHRENIA: OVERLAPPING PHENOTYPES
20. NEUROIMAGING OF PSYCHOTIC DISORDERS
21. COGNITIVE AND MOTIVATIONAL NEUROSCIENCE OF PSYCHOTIC DISORDERS
22. MOUSE MODELS OF SCHIZOPHRENIA AND BIPOLAR DISORDER
23. CORTICAL GABA NEURONS IN SCHIZOPHRENIA
24. SYNAPTIC DISEASE IN PSYCHIATRY
25. NEURODEVELOPMENT AND SCHIZOPHRENIA
26. NEUROBIOLOGY OF MENTAL ILLNESS PSYCHOSIS PRONENESS
27. PSYCHOTIC DISORDERS: NEUROCHEMISTRY AND PHARMACOTHERAPY
28. THE NEUROBIOLOGY OF BIPOLAR DISORDER
SECTION IV: MOOD DISORDERS
29. THE DIAGNOSIS OF MOOD DISORDERS
30. GENETICS OF DEPRESSION
31. ANIMAL MODELS OF MOOD DISORDERS
32. MOLECULAR AND CELLULAR PATHOGENESIS OF DEPRESSION AND MECHANISMS FOR TREATMENT RESPONSE
33. PATHOGENESIS OF DEPRESSION: CLINICAL STUDIES
34. NEURAL CIRCUITRY OF DEPRESSION
35. NEUROBIOLOGY OF DEPRESSION IN LATER LIFE: ANATOMY OF MELANCHOLIA
36. GONADAL STEROIDS AND MOOD DISORDERS
37. DEPRESSION AND MEDICAL ILLNESS
38. TREATMENTS FOR DEPRESSION
SECTION V: ANXIETY DISORDERS
39. DIAGNOSIS OF ANXIETY DISORDERS
40. GENETICS OF ANXIETY DISORDERS
41. NEUROBIOLOGY OF FEAR AND ANXIETY: CONTRIBUTIONS OF ANIMAL MODELS TO CURRENT UNDERSTANDING
42. DIFFERENTIAL ROLES OF GABA RECEPTORS IN ANXIETY
43. PREFRONTAL CORTEX REGULATION OF EMOTION AND ANXIETY
44. DEVELOPMENTAL COMPONENTS OF FEAR AND ANXIETY IN ANIMAL MODELS
45. FUNCTIONAL NEUROCIRCUITRY AND NEUROIMAGING STUDIES OF ANXIETY DISORDERS
46. NOVEL TREATMENT APPROACHES FOR ANXIETY DISORDERS
47. PHARMACOTHERAPY OF ANXIETY DISORDERS
48. NEUROBIOLOGY AND TREATMENT OF OCD
49. NEUROBIOLOGY AND TREATMENT OF PTSD
SECTION VI: SUBSTANCE USE DISORDERS
50. ANIMAL MODELS OF ADDICTION
51. CELLULAR AND MOLECULAR MECHANISMS OF ADDICTION
52. THE GENETIC BASIS OF ADDICTIVE DISORDERS
53. BRAIN DEVELOPMENT AND THE RISK FOR SUBSTANCE ABUSE
54. MOLECULAR IMAGING IN ADDICTIVE DISORDERS
55. BRAIN, REWARD, AND DRUG ADDICTION
56. MAGNETIC RESONANCE SPECTROSCOPY STUDIES IN SUBSTANCE ABUSERS
57. PHARMACOTHERAPY OF SUBSTANCE USE DISORDERS
58. EPIDEMIOLOGY OF SUBSTANCE USE DISORDERS
SECTION VII: DEMENTIA
59. CLINICAL AND NEUROPSYCHOLOGICAL FEATURES OF ALZHEIMER’S DISEASE
60. THE GENETICS OF ALZHEIMER’S DISEASE
61. EXPERIMENTAL ANIMAL MODELS OF ALZHEIMER’S DISEASE
62. STRUCTURAL, FUNCTIONAL, AND MOLECULAR NEUROIMAGING BIOMARKERS FOR ALZHEIMER’S DISEASE
63. FLUID BIOMARKERS FOR ALZHEIMER’S DISEASE
64. CURRENT THERAPIES FOR ALZHEIMER’S DISEASE
65. DISEASE-MODIFYING THERAPIES FOR ALZHEIMER’S DISEASE
66. LEWY BODY DEMENTIAS
67. CLINICAL FEATURES AND PATHOGENESIS OF FRONTOTEMPORAL DEMENTIA
68. PATHOGENESIS, DIAGNOSIS, AND TREATMENT OF VASCULAR AND MIXED DEMENTIAS
69. CLINICAL FEATURES AND PATHOGENESIS OF PRION DISEASE
SECTION VIII: PSYCHIATRIC DISORDERS OF CHILDHOOD ONSET
70. EPIDEMIOLOGY OF NEUROPSYCHIATRIC AND DEVELOPMENTAL DISORDERS OF CHILDHOOD
71. RARE VARIANTS OF SUBSTANTIAL EFFECT IN PSYCHIATRIC DISORDERS OF CHILDHOOD ONSET
72. EPIGENETICS IN EARLY LIFE PROGRAMMING
73. ANIMAL MODELS IN PSYCHIATRIC DISORDERS OF CHILDHOOD ONSET
74. NEUROPATHOLOGY AND SYNAPTIC ALTERATIONS IN NEURODEVELOPMENTAL DISORDERS
75. FUNCTIONAL CONNECTIVITY: APPLICATION TO DEVELOPMENTAL DISORDERS
76. INTELLECTUAL DISABILITY SYNDROMES
77. AUTISM SPECTRUM DISORDERS
78. NEUROBIOLOGY OF ATTENTION DEFICIT/HYPERACTIVITY DISORDER
79. TOURETTE SYNDROME AND TIC DISORDERS
80. NOVEL THERAPEUTICS IN CHILDHOOD ONSET PSYCHIATRIC DISORDERS
SECTION IX: SPECIAL TOPIC AREAS
81. DSM-5 OVERVIEW AND GOALS
82. THE INFIRMITIES OF PSYCHIATRIC DIAGNOSIS
83. TOWARD PRECISION MEDICINE IN PSYCHIATRY: THE NIMH RESEARCH DOMAIN CRITERIA PROJECT
84. THE NEUROBIOLOGY OF PERSONALITY DISORDERS: THE SHIFT TO DSM-5
85. THE NEUROBIOLOGY OF AGGRESSION
86. THE NEUROBIOLOGY OF SOCIAL ATTACHMENT
87. THE NEUROBIOLOGY OF SLEEP
88. THE NEUROBIOLOGY OF RESILIENCE
89. THE NEUROBIOLOGY OF EATING DISORDERS
INDEX
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