INDEX
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- Abbott Laboratories, 36–38, 49, 142
- Abilify, 507
- Abuse and Mental Health Services Administration, 377
- ACE inhibitors, 264
- acetaminophen, 216n, 396, 397
- Achrocidin, 181–82, 200, 222–23, 661n70
- Achromycin, 111
- acne, 58, 373
- Acthar, 512–14
- Actiq, 440, 485
- Activase, 337
- acute flaccid myelitis (AFM), 294n
- Adderall, 440
- addiction, 17, 25, 35, 47
- AIDS and, 347, 356
- benzodiazepines and, 222, 287, 289, 325, 684n19
- dependence confused with, 191, 257, 408, 414
- marijuana and, 259
- to opioids, see opioid addiction
- President’s Advisory Commission on Narcotic and Drug Abuse and, 191–92, 197–98, 199
- Adlon Therapeutics, 531
- Adrenalin, 27, 59, 69
- adrenaline, 27, 69, 264
- Advances in Pain Management, 478, 479
- adverse effects:
- from Chloromycetin, 163–64
- from combination antibiotics, 117
- from DMSO, 202
- from swine flu vaccine, 305–6
- from vaccines, 307–8
- adverse events:
- FDA definition of, 471–72
- see also side effects
- Advertising Age, 155
- advertising and promotion, 10n, 63–64, 67, 68, 73, 78, 79, 80, 90–94, 100–101, 124, 132, 159, 160, 162–64, 167, 201
- for amphetamines, 205
- of antibiotics, 92, 184, 239
- by detail men (sales representatives), see detail men
- celebrities, use of, 291, 431
- direct-to-consumer, 80, 153, 171, 207, 422–34
- disguised as news, 80, 153, 154, 172–73
- to doctors, 76, 91–93, 162–63, 168–69, 187, 188, 422–23
- FDA and, 80, 222–23
- Kefauver Amendments and, 184
- for Librium, 153–56, 171, 187
- in medical journals, 92, 100, 162, 219–20
- for Medrol, 167–68
- for MER/29, 168–70
- misleading and fraudulent, 35, 92–93, 124, 159, 162, 167–70, 201–2, 219–20, 222–23, 423, 425
- for Narphen, 216
- for OxyContin, 405–14, 438, 441–42, 445, 449, 451, 470, 472–75, 477, 480, 482, 483, 524
- for patent medicines, 8–9, 16, 18
- patient data and, 101, 111, 188, 325, 410, 413n, 638n91
- for phenobarbital, 205
- for pneumonia vaccine, 425, 427
- press releases as, 153–54
- radio, 93, 138, 155, 423, 426
- side effects and, 222, 423
- television, 423–27, 429–31, 433–34, 438
- for Terramycin, 63–64, 91–94, 96, 97
- for tetracycline, 111
- for Thorazine, 144, 145
- for Valium, 187, 205–6
- Advil, 380
- Aetna, 131
- Affordable Care Act (ACA), 406n, 496–97
- Africa:
- AIDS in, 345
- Ebola in, 310–13, 323
- African Americans:
- segregated blood donations from, 77, 314n, 356, 607n86
- Tuskegee Study on, 55n, 221, 246n
- Wright, 50, 53–56
- Afrin, 120
- After Forty (Gorney), 208
- Agouron, 384
- agriculture, 95, 232, 240, 518–19
- Agriculture, Department of, see United States Department of Agriculture
- AIDS, 3, 294, 309, 313n, 318–22, 341–55, 356, 398, 399, 464, 502–4, 520, 522
- AIDS Coalition to Unleash Power (ACT UP), 351
- AIDS drugs, 265, 332n, 351–54
- AZT, 348, 350–51, 353, 515–16, 704n49
- Daraprim, 515
- DDI, 351
- PrEP (pre-exposure prophylaxis), 354–55
- Air Force, U.S., 39
- alcohol, 17, 19, 20, 22, 215, 218
- prohibition of, 25, 26
- rectified whiskey, 15, 21, 24
- Alexion Pharmaceuticals, 511
- Alien Property Custodian, 72, 73, 165
- Allergan, 373, 486n, 508–10
- Alles, Gordon, 29
- Alodorm, 186n
- alprazolam (Xanax), 326–27
- Altace, 431
- Altman, Lawrence, 344–46
- America Invents Act, 369n
- American Academy of Pain Medicine, 364, 366, 406, 410, 480
- American Association for Retired Persons (AARP), 426
- American Association of Advertising Agencies (AAAA), 135n
- American Association of Blood Banks, 318
- American Brands, 155, 407
- American Cancer Society (ACS), 221, 291n
- American Cyanamid, 49, 111, 159, 379, 389
- American Home Products (AHP), 113–14, 147, 149, 206–7, 243n, 379, 380, 385n, 389
- American Hospital Association, 423
- American Medical Association (AMA), 10n, 16, 25, 54, 93, 103n, 120, 128, 148–49, 159, 171, 224, 239, 244, 410, 425
- Council on Drugs, 178, 179, 200
- Kefauver Amendments and, 180
- off-label use and, 371
- see also JAMA: The Journal of the American Medical Association
- American Pain Foundation (APF), 406, 487–88
- American Pain Society (APS), 361, 364, 406, 410, 414
- American Pharmaceutical Association, 9
- American Psychiatric Association, 204
- Diagnostic and Statistical Manual of Mental Disorders (DSM), 148, 327–28
- American Research and Development Corporation, 135
- American Society of Addiction Medicine, 364
- American Spectator, 349
- AmerisourceBergen, 484–86
- amethopterin, 51
- Amgen, 332n, 504
- amphetamines, 35, 141–42, 147n, 191, 198, 199, 201, 205, 206, 222, 226, 248, 257, 440, 454
- Benzedrine, 29, 39
- inhalers, 29
- sulfate, 29
- amyl nitrate, 340
- Amytal, 142
- Anacin, 113
- analgesics:
- in cold remedies, 181–82
- see also pain relievers
- Anatomy of Sleep, The, 408n
- Anderson College of Medicine, 67
- Andromeda Strain, The (Crichton), 249
- And the Band Played On (Shilts), 341
- anemia, 36
- anesthetics, 257, 485
- Anfuso, Victor, 112
- angiogenesis inhibitor therapies, 113
- Angiology Research Foundation, 91n, 108, 323n
- Annals of Internal Medicine, 364
- anthrax, 44
- antianxiety drugs, 94, 142, 145, 147n, 152, 206
- Antibiotic Medicine, 118, 119
- antibiotic resistance and superbugs, 2–3, 124, 183, 230–33, 517–21, 522, 663n14
- CRE (carbapenem-resistant Enterobacteriaceae), 1–3
- MRSA, 232n
- plasmids and, 232
- resistance genes and, 231–32
- antibiotics, 30n, 36, 42, 46, 48, 49, 52, 78, 95, 99, 131, 133, 141, 142, 149, 151, 153, 155, 159, 184, 189, 323, 337, 344, 376, 396, 517
- advertisements for, 92, 184, 239
- in agriculture and livestock, 95, 232, 240, 518–19
- Aureomycin, 53, 55–57, 58, 59, 61, 62, 99, 111
- broad-spectrum, 43, 46, 49, 53, 56, 59, 63, 94, 99, 111, 116, 231–32
- childhood growth rates and, 95n
- Chloromycetin, 59, 163–64
- coining of term, 43
- for colds, 181–83, 184, 200, 219, 222–23, 231, 232
- conferences on, 100, 118, 119, 133
- consequences of overuse, 58; see also antibiotic resistance and superbugs
- enthusiasm for, 58
- erythromycin, 112–13, 117
- FDA and, 63, 97, 100, 118, 119, 125, 131, 133, 181, 232, 267, 518–20
- FTC and, 122–23
- fixed-dose combination, 117–19, 124–25, 221–25, 227–28, 230, 232, 239
- natural, as best, 99
- overprescription of, 58, 124, 232, 517
- oxazolidinones, 520
- Panalba, 227–29, 230
- patents on, 45, 56
- penicillin, 29–39, 40–43, 46, 47–49, 51, 59–60, 62, 63, 94, 95, 113, 117, 124, 136, 137, 146, 230, 265, 314, 337, 356
- prices of, 112, 115, 117, 122–23, 128–29, 136, 158, 159, 500
- Sigmamycin, 117–19, 124–25, 221, 230
- soil and, 33, 43, 45, 52, 53, 60, 61, 95, 99
- spending on, 94
- streptomycin, 43–46, 48–49, 53, 59–60, 99, 117, 332n, 519
- synthetic, 99–100
- Terramycin, 61–64, 91–94, 96, 97, 99, 110, 156, 185
- tetracycline, 99, 110–12, 114–16, 122–23, 500
- Antibiotics and Chemotherapy, 97
- Antibiotics Annual, 100
- Antibiotic Therapy (Welch), 97
- anticonvulsants, 59
- antidepressants, 141, 145, 147n, 152, 189, 206, 521
- antihistamines, 59, 181, 324
- antipsychotics, 113, 144, 147n, 189, 372, 382
- antiseptics, 5, 248
- antitrust laws, 42
- anxiety, 148, 153, 187, 189, 327–28, 365
- Aspects of Anxiety, 203–5, 207
- women and, 203–6
- see also antianxiety drugs
- Armour, 399
- Army, U.S., 38n, 39, 77, 102, 204n, 233, 314
- arsenic, 16
- arthritis, 94, 154, 308n, 383, 433, 482, 508
- OxyContin prescribed for, 411, 415, 447, 466
- Ashcroft, John, 459
- Aspects of Anxiety, 203–5, 207
- aspirin, 10, 27, 397, 431
- Associated Press (AP), 121, 362n
- asthma, 500
- AstraZeneca, 521
- Crestor, 505–7
- Prilosec and Nexium, 432–33, 730n48, 752n29
- Seroquel, 382
- Ativan, 325
- Atlantic, 322n, 346
- Atomic Energy Commission, 102
- atypical hemolytic uremic syndrome (aHUS), 511
- Auden, W. H., 145
- Aureomycin, 53, 55–57, 58, 59, 61, 62, 99, 111
- autism, 295
- autoimmune disorders, 113, 428n
- Avastin, 505n
- Ayerst, McKenna & Harrison, 206
- Ayerst Laboratories, 206, 291, 379
- Inderal, 380–81
- Premarin, 206–9, 286, 290–92
- AZT (azidothymidine), 348, 350–51, 353, 515–16, 704n49
- bacteria, bacterial infections, 28–29, 36, 37, 58, 94, 344, 383
- Gram-positive and Gram-negative, 43, 53, 61
- in soil, 43
- see also antibiotics
- bacteria, good, 58, 231–32
- Bailey, Don, 513
- Baker, Stuart, 402
- Bakker, Tammy Faye, 324
- Bankhead, Tallulah, 148
- barbiturates, 21, 27, 35, 39, 142–43, 147, 149, 150, 152, 157n, 189, 191, 197, 199, 201, 206, 222, 248, 257, 258n, 287, 288, 288n, 289, 454
- phenobarbital, 21, 27, 205, 324
- Bard Pharmaceuticals, 107n, 108, 214, 217, 267, 268, 283, 375
- Vard, mistaken with, 107n, 622n70
- Barnet, Melvin, 105, 272
- Barron’s, 226
- Barr Pharma, 373
- BASF, 508
- Bates, Ted, 155
- bathhouses, 340, 341
- Baucus, Max, 487–88
- Baxter International, 320n
- Bayer, 10, 21, 25–27, 30n, 32, 36, 320n, 373, 396, 431
- Bayer, Friedrich, 5
- Bedford, Mass., Veterans Affairs Medical Center in, 121
- bedlamism, 144
- Beecham, 385, 389
- Begondi, Bob, 274n
- Benadryl, 59
- Benbow, Christopher Mitchell, 402, 525n
- benign essential blepharospasm (BEB), 373
- Benzedrine, 29, 39
- benzoate, 14, 21
- benzodiazepines, 151–53, 156, 185, 186n, 188, 199, 207, 258n, 264, 286, 287, 288n, 325, 329, 338, 400n, 440, 454
- Ativan, 325
- Halcion, 326, 327
- Klonopin, 186n, 325–27
- Librium, 152–57, 171, 185–90, 186n, 191, 192, 194, 197–98, 199, 201, 203, 205, 207, 222, 253, 256–58, 286, 287, 289, 325, 327, 409n
- Prazepam, 325
- Valium, 186–90, 186n, 191, 194, 201, 203, 205–7, 222, 248, 253, 256–58, 286–90, 324–29, 330, 379, 400n, 409n
- Xanax, 326–27
- Berg, Paul, 266, 336, 337
- Berger, Frank, 146–47, 149
- Berle, Milton, 148
- Bermuda, 525
- Bernstein, Leonard, 145
- Bernstein, Walter, 104–5
- beta blockers, 264
- Betadine, 248–50, 277, 397, 398
- Betadine Mouthwash Gargle, 245
- Bethune, Norman, 67–68
- “Big Pharma,” xi
- “Big Science,” 47
- Bill & Melinda Gates Foundation, 354
- Bingham, George Frederick, 82
- Bio Delivery Sciences, 486
- Biogen, 334, 504
- biologics, 240, 508
- biotechnology, 113, 266–67, 330–38, 384, 389, 404, 502, 504, 512
- Genentech-Lilly licensing contract and, 335–36
- start-ups, 336–37
- venture capitalists and, 331–32, 334, 336–38
- biotin, 150
- bioweapons, 44
- bipolar disorder, 143, 588n11
- birth control, 133n, 139n, 242, 243
- contraceptive pill, see contraceptive pill
- Dalkon Shield IUD, 243, 385n
- subdermal implants, patches, and injectables, 246
- birth deformities:
- from DES, 244
- from thalidomide, see thalidomide
- Bittman, William, 255
- Black, James, 264–65
- Black Plague, 28, 44, 53, 344, 520
- Blair, John, 128–33, 137–38
- blindness, 113
- blockbuster drugs, 149–50, 265, 384, 385, 412
- blood clots, blood clotting:
- Activase and, 337
- Factor VIII and, 316, 321
- blood donations, blood banks, 77, 318–22, 341, 347n, 399
- racial segregation of, 77, 314n, 356
- blood poisoning, 36, 37
- blood pressure, 263–64
- blood products, 39, 240, 334n
- Bloodsworth, Doris, 469–70
- blood-testing device, 338n
- Bloomberg, 498, 520
- Blue Cross, 130
- Blue Shield, 130
- Blumenthal, George, 282
- Blumenthal, Richard, 466, 468n
- Bogle, Jack, 337
- Boise, Bruce, 440n
- Bolar, 378
- Bolognesi, Dani, 348n
- Bonica, John, 361
- Boots, 424
- borax, 14
- Borison, Richard, 382
- Borkin, Joseph, 98
- Boston Collaborative Drug Surveillance Program, 361
- Boston Globe, 136, 526
- Boston University Hospital, 361–62
- Boston Women’s Health Book Collective, 244n
- Botox, 373–75, 509–10, 516
- botulinum toxin, 374
- Bourdette, Dennis, 514
- Bovet, Daniel, 264
- Boyer, Herbert, 266, 331–35
- Braithwaite, John, 115
- Branch, Charles Henry Hardin, 204
- Braun, Bob, 467
- Brazil (opioids in), 523
- breast cancer, 237–38, 241, 263, 291–93, 524
- breast implants, 428
- Brennan, John “Jack,” 122
- Bresch, Heather, 493, 499
- Bristol-Myers, 111, 114–15, 159, 351, 379, 380, 384, 385, 389, 431, 433
- FTC complaint against, 122–23, 159
- Bristol-Myers Squibb, 395–96, 460, 494
- Britain, 32, 38, 239
- Medical Research Council in, 32
- Medicines and Healthcare Products Regulatory Agency in, 339
- National Health Service in, 443, 656n22
- National Research Development Corporation in, 41n
- in World War II, 32
- British Journal of Anaesthesia, 409
- British Medical Journal, 216, 295
- Broady, John G., 114
- Broder, Samuel, 345–48, 350–51
- Brody, Jane, 237, 242, 375
- bromides, 27, 143
- Brompton cocktail, 212
- Brookings Institute, 282
- Brooklyn Eagle, 105
- Brooklyn Medical Press, 108
- Brooklyn Museum, 197
- Brown, Carter, 358
- Brown, Francis, 129, 160
- Brownlee, John, 457, 458, 463, 468–72, 474
- bubonic plague, 28, 44, 53, 344, 520
- Buchanan, Pat, 349, 350
- Buckley, William, 399
- buprenorphine, 482
- Burns, Kathleen Ingrid (Ingrid Frohlich), 71–72
- Burns, Thomas, 72
- Burroughs, Silas Mainville, 6
- Burroughs Wellcome, 6, 113, 141–42, 347–48, 389
- Bush, George H. W., 427
- Bush, George W., 457, 462n, 495
- Bush, Karen, 520, 521
- Business Week, 91
- Butrans, 482
- butyl nitrate, 340
- caffeine, 21–23
- Cahn, Linda, 495n
- Califano, Joseph A., Jr., 306, 308
- California, 516n
- Cambridge Antibody Technology, 508
- Cambronne, Luckner, 319
- Campbell, James, 364
- cancer, 20, 48, 113, 135, 202, 261, 262–63, 294, 332n, 338, 415, 524, 675n10
- breast, 237–38, 241, 263, 291–93, 524
- chemotherapy for, 51, 262–63, 371, 395–97
- contraceptive pill and, 237–38, 241, 246, 665n21
- DES and, 244, 667n60
- estrogen and, 207, 209, 244, 290, 686n45
- experimental trial on patients with, 220–21, 658n15
- leukemia, 51, 113, 507
- monoclonal antibodies and, 263
- smoking and, 94, 218
- war on, 247, 262, 331
- Cancer, 397
- cannabis, see marijuana
- Cant, Gilbert, 189, 287–88, 328–29
- Cantor, Gerald, 280, 281
- Cantor, Iris, 280
- Cap 1 LLC, 531
- Capote, Truman, 157n
- Capoten (captopril), 263–64, 387
- carbapenem-resistant Enterobacteriaceae (CRE), 1–3
- Cardinal Health, 484–86
- Caremark, 494, 497, 499
- Carson, Rachel, 175
- Carter, Buddy, 499
- Carter, Jimmy, 304, 306, 331, 377
- Carter Products, 146–49, 155–57, 222, 228
- Carter’s Little Liver Pills, 146
- Carter-Wallace, 157, 201, 253, 407
- Castagnoli, William, 93
- Catholic Church, 141, 212, 296n
- catsup, 22n
- cattle, 95, 232, 518
- celebrities:
- addictions and overdoses of, 288, 324
- in drug ads, 291, 431
- Celexa, 400n
- Centers for Disease Control and Prevention (CDC), 2, 200, 216n, 232n, 294n, 307, 479, 522, 524
- AIDS and, 345–48, 354
- antibiotic resistance and, 517–19
- Botox and, 374
- budget cut at, 343
- Ebola virus and, 310–12
- Legionnaire’s Disease and, 304
- OxyContin and, 417n, 420
- swine flu and, 296–306, 309
- Cephalon, 440
- Cephalon/Teva, 485
- cephalosporin, 99
- Cerezyme, 511
- Cerumenex, 110, 126
- cervical dystonia, 509
- Cetus, 336
- Chadbourne & Parke, 402
- Chain, Ernst, 30, 32–33, 40, 41, 231
- Chang Dai-chien, 283n
- Charlie Norwood VA Medical Center, 381–82
- Chayet, Neil, 257, 258
- Chef Boyardee, 113–14
- chemicals, environmental, 240
- pesticides, 113, 175, 240, 519
- chemotherapy, 51, 262–63, 371, 395–97
- Chemway Corp., 121–22
- Chesler, Phyllis, 287
- chicken pox, 28, 36, 296n, 344
- chickens, antibiotics used in, 95, 232, 518
- Children’s Health Insurance Program (CHIP), 494, 496, 513
- Chillicothe, Ohio, 3–4
- China, 67–68, 283, 520, 523
- Chinese art, 79, 81, 85–86, 192–97, 283, 357, 358
- chlamydia, 56
- chloroform, 19
- Chloromycetin, 59, 162–64
- Chlorpheniramine, 324
- chlorpropamide, 93n
- cholera, 7, 9, 43
- cholesterol drugs, 386, 431, 521
- Crestor, 505–7
- Lipitor, 370, 431–32
- MER/29, 168–70, 174
- Repatha, 505
- Cialis, 373n
- Ciba Chemical, 68, 136, 142, 143, 202, 273
- Ciba-Geigy, 277, 379
- cigarettes, 92, 94–95, 218, 261, 428
- Cigna, 131
- cimetidine (Tagamet), 264–65, 383–85, 387
- Cipro, 396
- citric acid, 59
- citrus greening disease, 519
- Civil War, 5–6, 52
- Claritin, 429–31
- Clark, David, 235
- Clines, Francis X., 439
- clinical trials, 162, 376, 404, 409
- consent of participants in, 220
- double-blind, 178
- FDA and, 152, 176–78, 180, 219, 369, 404, 506n
- for OxyContin, 405, 409, 415, 446
- Clinoril, 383
- Clinton, Bill, 246n, 494
- clonazepam (Klonopin), 186n, 325–27
- Coca-Cola, 22–24
- cocaine, 4, 7–8, 17, 19, 20, 22–24, 25, 26, 34n, 198, 212, 215, 257, 325n, 448, 482–83
- patent drugs with, 7–8, 17, 578n19, 21
- popularization by Paolo Mantegazza, 577n13
- Cocoanut Grove nightclub fire, 38
- codeine, 10, 26, 157n, 216n, 258, 324
- cod liver oil, 76
- coffee, 22, 22n, 23
- Coffee, John, 527
- Cohen, Stanley, 266, 331–32, 337
- cola, 22
- colds, cold remedies, 181–83, 184, 200, 219, 222–23, 231, 232, 239, 245
- Cold War, 78, 145, 159, 272
- College of Pharmacy, 85
- Collier’s, 16–17, 19, 59
- Colony Club, 72
- Columbia Journalism Review, 469
- Columbia University, 134, 192, 195, 272, 394n
- Comey, James, 471
- Commercial Solvent, 41n
- Communicable Disease Center, 200, 202
- Communications Associates, 106
- Communist Party, communists, 69–70, 74–78, 81, 101–2, 104–6, 109, 272, 399, 639n105
- compactin, 386, 387
- Comprehensive Drug Abuse Prevention and Control Act, 257
- congestive heart failure, 263–64, 371–72
- Congo, 310–12, 318, 345n
- Congress, U.S., 10, 15–19, 22, 34–35, 41, 49, 59, 92, 95, 112, 143, 160, 162, 179, 200, 223, 229, 248, 255, 262, 429, 495n, 507, 517, 524
- biotechnology and, 330
- opioid restrictions and, 364
- OxyContin and, 448, 449
- patent extensions and, 376
- Shkreli and, 515
- Smithsonian and, 358, 359
- swine flu and, 300–303, 307
- see also House of Representatives, U.S.; Senate, U.S.
- Connor, John, 129
- Conover, Lloyd, 99–100
- Console, A. Dale, 130
- Consumer Product Safety Commission, 240
- consumers:
- activists and advocacy groups for, 423, 431
- class action litigation and, 245
- direct advertising to, 80, 153, 171, 207, 422–34
- contagious infections, 28–29, 36
- contraceptive pill, 94, 133n, 139–41, 153, 202, 222, 234–46, 247, 287, 292, 400n
- cancer and, 237–38, 241, 246
- death from, 234–37, 239, 246
- Enovid, 139–41, 234–36, 243, 246
- FDA and, 139, 141, 234–36, 238–45
- as gateway drug, 238
- labeling of, 244–45
- off-label uses of, 373
- side effects from, 234–46
- women as guinea pigs for, 241, 246n
- Controlled Substances Act, 256–57, 289, 324, 360, 378, 483, 484
- convergence science, 284
- Cooper, Ellen, 353
- Copland, Aaron, 72
- copper sulfate, 14
- copyright, 8, 27
- Corfman, Philip, 238
- Coricidin, 120
- corn syrup, 21
- corticosteroids, 38–39, 115, 167–68, 228
- cortisone, 37, 60, 85, 113, 115, 160
- Cosmopolitan, 155
- costs of drugs, see prices
- Coté, Tim, 504
- Council of Community Blood Centers, 318
- Courier-News, 464, 465, 467
- Courtland Laboratories, 318
- CRE (carbapenem-resistant Enterobacteriaceae), 1–3
- Creedmoor Psychiatric Center, 76, 78, 79, 82–85, 88, 101–2, 133, 135, 142, 145, 156
- Institute of Psychobiological Studies at, 85
- Van Ophuijsen Center at, 98, 108, 132n
- Crestor, 505–7
- Crichton, Michael, 249
- crime, 247, 257–58
- Crohn’s disease, 508
- Crookes-Barnes, 122
- Crowley, John, 483–84
- Cruciani, Ricardo, 479
- Cryptococcal meningitis, 312
- Cryptosporidium, 312
- Cubist, 520
- cures for diseases, 27, 45, 126, 143, 176
- Curie, Marie, 328
- Curran, James, 345
- Curtis, Tom, 345n
- Cutter Laboratories, 113–14, 315
- CVS, 490, 497
- cyclosporine, 383
- cytomegalovirus (CMV), 321–22, 343
- Daily Mail, 529
- dairy products, 12, 14
- Dale, Henry, 32
- Dalí, Gala, 149
- Dalí, Salvador, 148–49
- Dalkon Shield, 243, 385n
- Dalmane, 186n
- Dangerfield, Rodney, 324
- Daraprim, 515
- Darwin, Charles, 28
- Davies, Sally, 517–18
- Davis, George Solomon, 6
- Davis, Hugh, 241, 243
- Davis, Leo, 104–5
- Dayen, David, 499
- D.C. Women’s Liberation, 242
- DDI (dideoxyinosine), 351
- DDT, 175n
- Dean, John, 255
- death:
- care before, see end-of-life care
- right to die, 424
- deaths, drug, 5, 34, 488
- from benzodiazepines, 288n
- from contraceptive pill, 234–37, 239, 246
- from opioids, 368, 413, 435, 490–91, 523–24
- from OxyContin, 435, 439, 441, 444, 445, 449, 454–56, 479, 482–83, 490–91, 522
- of rock stars, 288, 324
- from swine flu vaccinations, 203
- from Vioxx, 485
- Debs, Eugene V., 66
- decongestants, 29, 181
- Defense Department, 331, 334
- Demerol, 157n, 324
- dengue fever, 307–8
- dental issues, 58, 257
- Depostat, 246n
- depression, 153, 327, 365, 400n, 521
- rating scales for, 153, 365
- see also antidepressants
- Depression, Great, 36, 47, 66, 74
- DES (diethylstilbestrol), 244
- Desoxyn, 142
- detail men (sales representatives; drug reps), 62–63, 91, 93–94, 153, 155, 156, 163, 170–71, 182, 646n32
- changing nature of, 416
- compensation for, 415–17, 421, 451–52, 480–81, 489
- doubling of, 416
- one-on-one sales pitches by, 407
- OxyContin and, 410–13, 415–21, 451–53, 477, 480–84, 487, 489
- Detrol, 431
- DeVita, Vincent, 345–47
- Dexamyl, 142
- Dexedrine, 142
- diabetes, 29, 93n, 113, 128–29, 208, 332n, 521
- Diabinese, 113
- Diagnostic and Statistical Manual of Mental Disorders (DSM), 148, 327–28
- diamorphine, see heroin
- diazepam, see Valium
- dideoxyinosine (DDI), 351
- Dietary Health and Education Act, 428
- diet drugs, 141, 205, 225–26, 374
- diethylstilbestrol (DES), 244
- Dilantin, 59
- Dillon, C. Douglas, 282
- Dingell, John, 425, 426
- Dinkeloo, John, 285
- diphtheria, 27, 307
- diseases and conditions:
- breaking into subsets, 503–6, 510n
- chronic, 323, 521
- cures for, 27, 45, 126
- infectious, see infections, infectious diseases
- lifestyle choices as cause of, 94–95
- distribution, 62, 493–99
- Diversified Pharmaceutical Services, 494
- Dixon, James, 191n
- Dixon, Paul Rand, 128, 131
- DMSO, 202
- DNA, 334n
- recombinant DNA (rDNA) technology, 266–67, 330–36
- doctors, 62–63, 160
- advertising and promotions directed at, 76, 91–93, 162–63, 168–69, 187, 188, 422–23
- continuing education for, 188
- detail men (sales representatives) and, see detail men
- fake, in advertisements, 125, 230
- free samples given to, 124, 187–88, 223
- gifts and perks for, 223, 413, 442, 509, 641n29
- off-label prescribing and, 353, 354, 370–71, 373–74
- Doctors Blood Bank, 316
- Doctors’ Case Against the Pill, The (Seaman), 237
- Dodd, Christopher, 461
- Dodd, Martha, 73, 119, 165, 166
- Dodd, Thomas, 199
- Dole, Bob, 235, 431
- Domagk, Gerhard, 30n
- dopamine, 215
- Doriot, Georges, 134–36
- double-blind trials, 178
- Douglas, William, 229
- Dow Corning, 428
- Drake Business Schools, 67, 68
- Drew, Charles Richard, 314
- Dreyfus, Robert Louis, 274n
- Dr. Kade Pharmaceutical, 81, 83, 193, 267
- drug abuse, 199, 247, 256–58
- drug schedules and, 256–58, 260n, 289
- OxyContin, 435–50, 451–62, 470–71, 473, 475, 477, 480, 481, 483; see also OxyContin
- see also addiction
- Drug Abuse Control Amendments, 146n, 199–200, 222
- Drug Enforcement Administration (DEA), xi, 199, 289, 378, 405, 458
- Lifetree Pain Clinic and, 479
- OxyContin and, 441–45, 449, 450, 451, 453–59, 463, 472, 475, 479, 484–86
- Druggists’ Circular, 9
- Drug Industry Antitrust Act, 158–59
- Drug Price Competition and Patent Term Restoration Act (Hatch-Waxman Act), 380–81, 393, 395
- Drug Regulation Reform Act, 377
- drug reps, see detail men
- Drummond, William, 79
- Dubow, David, 103, 274n
- Duffield, Samuel Pearce, 6
- Dugas, Gaëtas, 342
- Duggar, Benjamin, 50–53, 55, 57
- Duggar, Reuben Henry, 52
- Dull, H. Bruce, 297
- Dumpson, James, 191n
- Dun & Bradstreet, 401
- Dunbar, Walter, 58–59
- DuPont, 108, 175
- Duragesic, 407, 485
- Durham-Humphrey Amendment, 143, 646n32
- Duvalier, François “Papa Doc,” 319
- dye industry, 32
- earwax removal products, 110, 126
- Ebola virus, 310–13, 323
- E. coli, 266, 334, 335
- Economist, 141
- ecstasy, 257, 373
- Edison, Thomas, 100, 328
- Edrisal, 147n
- Edward VIII, King, 71
- Edwards, Charles, 239–42, 244–45
- efficacy of drugs, 176–78, 180, 219, 221–25, 227–29, 376–77, 407
- Effman, Lawrence, 195, 273
- Egeberg, Roger, 192n
- Egypt, 279, 280
- Ehrlichman, John, 391n
- Eisenhower, Dwight, 48, 100, 128, 181, 282
- Eisenstein, Barry, 520, 521
- electroshock therapy, 144
- Eli Lilly and Company, 6, 27, 29, 33, 36–39, 44, 49, 136, 142, 143, 154–55, 158, 222, 225, 332n, 384, 426, 494, 516
- Cialis, 373n
- Genentech’s licensing contract with, 335–36
- Prozac, 328, 400n
- synthetic insulin and, 334–36
- Elipten, 202
- Elizabeth II, Queen, 213, 284, 458
- Ellenhorn, Matthew, 187
- Elliott, Carl, 416
- Embeda, 485
- “emotional aspirin,” 94, 145–46
- EMS workers, 524
- Enbrel, 508
- end-of-life care, 210–17, 218, 257, 269, 339, 363, 396, 408, 414
- Endo, 440, 486n, 487
- Endo, Akira, 386, 387
- endorphin, 215
- England, see Britain
- enkephalin, 215
- Enovid, 139–41, 234–36, 243, 246
- environmental chemicals, 240
- pesticides, 113, 175, 240, 519
- Environmental Protection Agency (EPA), 175n, 240, 250, 519
- EOP Technology, 227n
- epidemics, 9, 28, 692n16
- influenza (1918), 27–28, 65, 296–97, 305, 307, 344, 520
- opioid addiction, see opioid epidemic
- epinephrine, 27, 180
- EpiPen, 493, 499
- Equanil, 147, 148, 153, 155–57, 189, 201, 222, 228
- erectile dysfunction, 373n, 431, 433–34
- erythromycin, 112–13, 117
- estrogen, 206–9, 236n, 241, 246, 291
- cancer and, 207, 209, 244, 290
- DES (diethylstilbestrol), 244
- marketing to women, 207–9
- Premarin, 206–9, 286, 290–92
- Prempro, 291–92, 374
- “ethical pharmaceuticals,” 9–10
- Ethinamate, 324
- Euro-Celtique, 396
- euthanasia, 210, 212
- Excalibur International Group, 278
- Express Scripts, 497, 499
- eye conditions, 113, 373, 511
- blindness, 113
- river blindness, 388, 394
- Factor VIII, 316, 321
- Family Circle, 140, 141, 155, 422
- Famularo, Joseph, 439
- Farber, Sidney, 51
- farming, antibiotics use in, 95, 232, 240, 518–19
- Fauci, Tony, 345–47
- Federal Bureau of Investigation (FBI), xi, 68–70, 74–78, 75n, 101–2, 104–7, 109, 110, 165–66
- Federal Civil Procedure, 245
- Federal Trade Commission (FTC), 35, 92, 112, 114, 128, 159, 162, 201
- antibiotics and, 122–23
- antitrust complaint by, 122–23
- Aspects of Anxiety and, 203–4
- fake doctor exposé and, 125
- unfair practice complaint by, 125
- Feminine Forever (Wilson), 207–9
- Feminine Mystique, The (Friedan), 202
- feminism, 140, 202, 204–5
- fenfluramine, 374
- fen-phen, 374
- fentanyl, 257, 440, 485
- Cephalon illegal marketing of, 440n
- filariasis, 388
- Fincle, Louis, 121
- Finland, Max, 123, 124, 221
- First International Congress of Psychiatry, 84–85
- Fisher, Alice, 472
- Fleming, Alexander, 29–30, 40, 63, 95n, 230
- Fletcher, Charles, 31
- Florey, Howard, 30–34, 36, 37, 40, 63
- Florida, 460, 461, 463, 469, 519, 529
- flu, see influenza
- Foley, Kathleen, 363–64
- folic acid, 51
- Folkman, Judah, 113
- follicular B-cell non-Hodgkin’s lymphoma, 504–5
- Fong, Wen, 193–94, 283
- Food, Drug, and Cosmetic Act, 34, 63, 143
- Kefauver Amendments, 176–83, 184, 186, 187, 200, 201, 220, 221, 228, 302, 369, 376, 512
- Medical Device Amendments, 240, 243n
- Food and Drug Administration (FDA), xi, 2, 10, 34n, 35, 41, 58–59, 62, 63, 82, 91, 92, 100, 112, 124, 126, 133n, 134, 146, 174, 176–83, 185, 187, 191, 199–201, 216, 216n, 218–29, 239–40, 264–66, 308n, 361, 440, 444, 454, 531, 532
- Activase and, 337
- adverse events as defined by, 471–72
- AIDS and, 350, 353, 398, 399
- antibiotics and, 63, 97, 100, 118, 119, 125, 131, 133, 232, 267, 518–20
- approval process and “drug lag” in, 176–78, 180, 398
- Aspects of Anxiety and, 203–4
- AZT and, 350, 353
- barbiturates and, 143
- blood donations and, 316n, 317, 320n
- Botox and, 510
- budget cuts at, 377, 398, 425, 427
- Chloromycetin and, 164
- clinical trials and, 152, 176–78, 180, 219, 369, 404, 506n
- contraceptive implants and injectables and, 246n
- contraceptive pill and, 139, 141, 234–36, 238–45
- corruption in approval process at, 427
- DES and, 244
- direct-to-consumer advertising and, 80, 153, 171, 207, 422–34
- drug advertising and, 80, 222–23
- drug efficacy and, 176–78, 219, 221–25, 227–29, 407
- Drug Efficacy Study Implementation (DESI) task force of, 225, 227, 228
- Drug Regulation Reform Act and, 377
- drugs decertified and recalled by, 35, 176, 182, 184, 200, 219, 225, 227–29, 230, 245, 433
- Durham-Humphrey Amendment and, 143
- Edwards at, 239–42, 244–45
- expansion of, 181
- Feminine Forever and, 209
- generic drugs and, 158, 184, 377, 378, 380–82
- Goddard at, 200–203, 207–9, 210, 218–27
- Halcion and, 326
- Hayes at, 424–26
- Kefauver Amendments and, 176–83, 186, 187, 200, 201, 228
- Kessler at, 427–30, 433
- Larrick at, 181, 182, 200–201, 227
- Ley at, 227, 228, 239
- L-Glutavite and, 120
- Librium and, 152, 153, 171, 185, 186, 253, 289, 409n
- LSD and, 146n
- medical devices and diagnostic products overseen by, 240, 243n
- MER/29 and, 169–70
- Miltown and, 147, 149, 150, 253
- MST Continus and, 369, 395
- New Drug division split into departments, 177
- number of drugs approved since 1938, 371
- off-label use and, 371–75
- one-on-one sales pitches and, 407
- opioids and, 364, 367, 461
- orphan drugs and, 352, 502–16
- OxyContin and, 405, 408, 412, 415, 417–20, 438, 440, 442, 446–48, 451, 453–54, 456–57, 460, 463, 465–66, 468, 469, 471–72, 475, 481, 483, 523
- OxyContin generic versions and, 488–89
- OxyContin patent extension and, 481, 488–89
- in partnership with drug industry, 398
- patent dates and, 395
- patent extensions and, 379
- patient-packet inserts and, 424
- pharmaceutical industry’s relationship with, 4
- Premarin and, 206, 290
- Quaaludes and, 378
- Scientific Investigations Staff in, 219
- Sigmamycin and, 117
- stimulants and, 142
- swine flu vaccine and, 300
- synthetic insulin and, 335, 336
- television ads and, 429–31
- Terramycin and, 94
- thalidomide and, 174, 177, 181, 219
- tobacco and, 218, 428
- Valium and, 186, 187, 253, 289, 324, 409n
- Vioxx and, 485
- weight loss drugs and, 225–26
- Welch at, 63, 118, 119, 124, 131–35, 139, 181
- Xanax and, 326, 327
- Young at, 398, 426–27
- Young Turks at, 176
- Food and Drugs Safety Act, 223
- food labels, 428
- food safety, 10–14, 15, 240
- coloring agents and, 34n
- Pure Food and Drug Act, 17–24, 34
- Forbes, 490, 493
- Ford, Betty, 304, 325
- Ford, Gerald, 298–304
- Ford, Henry, 100
- Ford Foundation, 213, 227n
- formaldehyde, 12, 14
- Fort Dix, 296, 297, 302, 304, 308
- Fortune, 60, 190, 393–94, 450
- Fortune 500 companies, 392, 450, 486, 497
- 48 Hours, 382, 449
- Forverts, 66
- France, 26
- Franco, Francisco, 89
- Fredrickson, Donald, 330–31
- Freedom of Information Act, xi, 104
- Freer, Charles, 358
- Freer Gallery of Art, 358–59
- free samples, 124, 187–88, 223
- Freud, Sigmund, 7n, 76, 202, 203, 327
- Friedan, Betty, 202
- Friedman, Michael, 436–38, 444, 448, 453, 460, 468, 472–76, 478
- Friedman, Milton, 180
- Friedman-Klein, Alvin, 343
- Frohlich, Ingrid, 71–72
- Frohlich, Ludwig Wolfgang (Bill), 70–73, 76, 77, 90, 100–101, 103, 106n, 110, 111, 119, 122, 123, 133, 140, 164, 171, 173, 181–82, 188, 195, 206–7, 220, 222–23, 270, 277, 401–2, 410
- corporations of, 110
- death of, 260, 261, 273–74
- L. W. Frohlich Inc., 73, 80, 106n, 110n, 134, 164, 195, 270, 273, 430
- Martí-Ibáñez and, 90
- Sackler and, 70, 72–74, 79–80, 85
- Frontline, 526
- Frosh, Brian, 532
- Fukuda, Keiji, 308–9
- fusidic acid, 99
- gabapentin, 375
- gangrene, 36
- Garrett, Laurie, 307
- Garrison, Jim, ix
- Gates Foundation, 354
- Gaucher disease, 511
- Gauvin, David, 445, 453–57
- Gay Freedom Day Parade, 339–40
- Gay Liberation movement, 340, 341, 349
- Genentech, 332–38, 339, 389, 504, 505n, 507
- Activase, 337
- IPO of, 336
- Lilly’s licensing contract with, 335–36
- generalized anxiety disorder (GAD), 328
- generic drugs, 158, 163, 171, 184, 352, 376–82, 383, 395, 506
- Hatch-Waxman Act and, 380–81, 393, 395
- “pay for delay” and, 396
- prices of, 499–500
- quality concerns, 163, 380
- Generic Trade Association, 378–79
- genetic engineering, 266–67, 332n
- genetic research, 330, 332–35, 511
- Genetic Systems, 384
- Genzyme, 511
- George VI, King, 40
- Gerard, Ralph, 150
- Germany:
- Nazi, 30, 30n, 37, 39, 39n, 44, 47, 68–71, 75, 81, 84, 220
- pharmaceutical companies in, 5, 26, 30n, 42, 68, 137, 150
- Weimar Republic, 75
- germs, see microbes
- germ theory, 6–7
- Gerson, Irwin “Win,” 153, 187, 189
- Gilead, 354–55
- Gilbert, Walter, 333, 334
- Gilgore, Sheldon, 272
- Gimbel, Sophie, 71–72
- Gingrich, Newt, 429
- Giuliani, Rudy, 458–59, 461–62, 466, 471, 472, 475
- Giuliani Partners, 458–59, 462n
- glaucoma, 94, 383
- Glaxo, 153, 267, 379, 384, 389
- Glaxo SmithKline, 389
- Gleevec, Novartis, 507
- Global Day Against Pain, 470
- glutamate, 120
- Goddard, James, 200–203, 207–9, 210, 218–27
- Goeddel, David, 333
- Goldburt, Louis, 98, 107, 107n, 194–95, 273
- Goldenheim, Paul, 444, 448, 449, 453, 455, 472–76, 478
- Goldin, Nan, 528
- Golos, Jacob, 106
- gonorrhea, 43, 341
- Good Housekeeping, 23–24
- Good Housekeeping Seal of Approval, 24
- Goodman, Christopher, 375
- Goodman, Howard, 333
- Good Morning America, 368, 431
- Goodrich, William, 218
- Gordon, Alex, 105
- Gordon, Barbara, 324
- Gordon, Max, 105
- Gorinsteen, Joseph, 319
- Gorney, Sondra, 208
- Government Accountability Office, 453, 499–500
- Grant, William, 276
- Grassley, Chuck, 487–88
- Gray, John Purdue, 82
- Gray Pharmaceutical Company, 119, 122
- Gray’s Compound, 82, 96, 171
- Great Britain, see Britain
- Great Depression, 36, 47, 66, 74
- Great Physiodynamic Therapies in Psychiatry, The: An Historical Reappraisal (Martí-Ibáñez et al., eds.), 88, 166
- Great Society, 223
- Greene, Martin, 107n, 194–95, 323n, 458n
- Greene, Myron J., 107n, 194–95, 458n
- Greitzer, Carol, 106n
- Griffith, Chelly, 469
- Gross, Chaim, 65
- Gross, Michael, 357n
- Guardian, 439n, 527
- Guillain-Barré syndrome, 305–6
- Gusberg, Saul, 209
- gynecologists, 236n, 291
- Haberman, Helen, 78n, 173
- Haddox, J. David, 366, 405, 419, 436–47, 439, 442, 460, 466–67
- pseudoaddictions, theory of, 366, 419, 466, 479
- Haffner, Marlene, 504, 516
- Haffner Associates, 504
- hair growth, 372
- Haiti, 318–21
- Halcion, 326, 327
- halitosis, 102
- hallucinogens, 255–56
- Halpern, Alfred, 78, 268
- Hamill, Dorothy, 433
- Hamilton Rating Scales, 153, 365
- hand, foot, and mouth disease, 294n
- Harlem Hospital, 55, 62, 74, 76
- Harris, Ben, 75n, 77
- Harris, Henry, 41
- Harrison Narcotics Tax Act, 25–26, 199
- Harrower, Henry, 102
- Harrower Laboratory, 102
- Harvard Art Museums, 283, 359
- Arthur M. Sackler Museum, 359
- Harvard University, 50–51, 54, 62, 283, 332–33, 371, 528
- Hatch, Orrin, 378–79, 488n
- Hatch-Waxman Act, 380–81, 393, 395
- Hattwick, Michael, 305
- Hawkes, Ashton, 281
- Hayden Chemical, 111
- Hayes, Arthur, Jr., 424–26
- Hazeltine & Co., 20
- Health Affairs, 414n
- health care:
- Affordable Care Act, 406n, 496–97
- Americans’ spending on, 492, 502
- Children’s Health Insurance Program, 494, 496, 513
- federal programs for, 128, 223–24
- HMOs, 390–92, 494
- insurance, 130–31, 223, 350, 390, 391, 417, 418, 439n, 494, 496, 497
- managed care, 390–92, 494
- Medicaid, 223–24, 289, 390, 439n, 440n, 449, 478, 493, 494, 496–98, 509, 513, 515
- Medicare, 223, 224n, 439n, 440n, 478, 494–95, 497, 498, 501n, 509, 513, 514
- prescription drugs for seniors, 494–95
- Health Horizons, 171
- Health Maintenance Organization Act, 390
- Health Research Group, 328, 423, 426
- heart disease, 56, 94–95, 332n
- congestive heart failure, 263–64, 371–72
- Heatley, Norman, 32–33, 37, 40, 41
- Heines, James, 467
- Heinz Company, 22n
- Hellman, Lillian, 777
- Hellman, Louis, 238
- Hemo-Caribbean, 319–21
- as possible source of HIV transmission 320–21, 695n60
- hemophiliacs, 316–17, 321, 347n
- Hendrix, Jimi, 288
- hepatitis, 313, 315, 317, 320, 312, 334n, 341
- herbal remedies, 20
- Herceptin, 505n, 507
- heroin, 4, 10, 17, 19, 21, 24, 25–27, 143, 212, 214, 247, 257, 260n, 325n, 396, 397, 420, 437, 439, 441, 448, 482–83, 488n,522
- Hertz, Roy, 237–38, 241
- HEW (United States Department of Health, Education, and Welfare), 34n, 48, 100, 133–34, 200, 239, 248, 256, 298, 301, 306, 308, 330
- HHS (United States Department of Health and Human Services), 377, 427, 435, 460, 478, 495n, 500
- high blood pressure drugs, see hypertension drugs
- Hildene Capital Management, 527
- Hinckley, John, 325n
- histamines, 88, 264–65
- Hitler, Adolf, 30n, 75
- HIV-AIDS, see AIDS
- HMOs, 390–92, 494
- Hobby, Gladys, 62
- Hoechst AG, 26
- Hoechst-Roussel, 153
- Hoffmann-La Roche, see Roche
- Hogen, Robin, 467–68
- Hollings, Fritz, 460
- Holmes, Edward, 346n
- Holmes, Elizabeth, 338n
- Hooper, Edward, 345n
- Hoover, J. Edgar, 77
- hormones, 36, 76, 94, 128, 136
- combination HRT, 291–92
- estrogen, see estrogen
- menopause and, 206–9, 236n, 290–92
- Prempro, 291–92, 374
- progesterone, 236n, 246, 291
- progestin, 291
- see also contraceptive pill
- Horne, Ken, 342
- hospice, 210–17, 257, 269, 339, 363
- hospitals, 167
- Hostetter, Jacob, 9
- House of Representatives, U.S.:
- Committee on Government Operations, 112
- Oversight and Government Reform Committee, 499
- Subcommittee on Intergovernmental Relations, 114
- Subcommittee on Oversight and Investigations, 448, 449
- Un-American Activities Committee (HUAC), 104, 106, 106n, 119
- Hoving, Thomas, 193, 194, 196, 279–81, 283, 285, 357
- How to Live Longer and Feel Better (Pauling), 399
- Hruska, Roman, 173
- Humira, 507–8
- Humphrey, Hubert, 179, 185, 226
- Humphreys, Keith, 523
- Huntington’s disease, 377
- Hussey, Hugh, 159
- Hutchinson, Asa, 458, 459
- hydrochlorothiazide, 201
- hydrocodone, 26–27, 216n, 360, 440
- Hygienic Table Trial, 13
- Hyland Labs, 314, 318
- hypertension drugs, 136, 143, 372, 431, 521
- hysteria, 202–3
- Ibuprin, 380
- ibuprofen, 379–80
- Identifying Granular Growth Opportunities for OxyContin: First Board Update, 489–90
- I. G. Farben, 30n
- illegal drugs, 26, 34n, 198, 199, 247–48, 255–56, 289
- convictions for, 255
- OxyContin diversion, 435–39, 441–46, 448–49, 451–62, 473, 480, 483–85
- marijuana as, 198, 259
- Imbrium, 531
- immigrants, 7, 19
- Immigration Act, 7
- immune globulins, 39
- immunization, see vaccines
- IMS Health, 101, 103, 111, 133, 188, 260, 273–74, 325, 401, 410–11, 413n
- as aid in marketing drugs, 111, 188, 325, 410, 413n, 638n91, 723n69
- Cornerstone software, 411, 415–16
- corporate structure, 101, 103, 617n18
- role in Sackler estate dispute, 273–74, 401, 679n24
- in Sackler ownership, 101, 133, 273, 274, 679n24
- Inderal, 380–81
- India, 523
- infants, 9, 468
- infections, infectious diseases, 28–29, 39, 48, 323
- Infectious Diseases Society of America, 2, 58n
- influenza, 296, 305
- bird flu, 296
- epidemic of 1918, 27–28, 65, 296–97, 305, 307, 344, 520
- swine flu, 296–309, 348, 520
- vaccines for, 297n, 304, 305, 344
- Information Center on the Mature Woman, 208
- insecticides, 113, 175, 240, 519
- Institute for Psychoanalysis, 73, 85
- insulin, 29, 40n, 93n, 158, 208, 335, 500
- as shock treatments for mental conditions, 612n4
- synthetic, 332–36
- intellectual property (IP), 252
- copyright, 8, 27
- trademarks, 158
- Inter America Medical Press, 91n, 108
- Intercontinental Medical Information Service, 101
- interferon, 113
- interleukin-2 inhibitors, 336, 383
- Internal Revenue Service (IRS), 131
- International Academy of Law & Science, 165n
- International Association for the Study of Pain, 361
- International Business and Financial Weekly, 179
- International Marketing Services, see IMS Health
- International Medical Press, 91n, 108
- International Opium Convention, 25
- internet, 429
- as source of patient information, 429, 724n77
- iodine, 248
- Isodine, 245
- Israel, 280
- Itakura, Keiichi, 333–34
- IUD, Dalkon Shield, 243, 385n