INDEX

Page numbers in italics refer to tables and charts.

acanthosis nigricans, 220

acetylcholine, 136

acne, 47, 140, 205, 206, 210, 211, 223–24, 229, 230

ACTH (adrenocorticotropin), 92, 320, 329

acting “as if,” 297

acupuncture, 102, 181, 275

and low estrogen, 190

for PCOS, 227–28

and PMS, 147

adaptogens, 109–10

Addison’s disease (primary adrenal insufficiency), 91, 118, 320

adenocarcenoma, 249

adiponectin, 42

function of, 329

adopokines, 214

adrenal cortex, 94

adrenal dysregulation, 50, 268, 320

downward spiral from adrenal health to, 93–94

as overlooked in mainstream medicine, 33, 71, 82

stress and, 277

see also dysregulated (high/low) cortisol

adrenal glands, 12, 61, 81, 91, 92, 272, 320

function of, 42, 44, 90–91, 128–29, 208, 247, 272

organ reserve in, 5–6, 213

stress and, 5, 6, 61, 71, 76, 77, 114

tumors of, 206

adrenaline, see epinephrine (adrenaline)

African dance, 116, 266

agency, sense of, 206

aggression, 53, 209

aging:

accelerated, 6, 8, 20, 79–80, 84, 213, 253, 276, 290

biological vs. chronological, 84, 86

cortisol and, 78–82

decelerated, xi, xiii, xviii, 119, 260

degenerative, 14

estrogen dominance in, 153

healthy, xi, 20

hormonal arc in, 274–75

hormone imbalance and, xix, 35, 49, 240, 250, 264

and low progesterone, 133

misconceptions about, xii

and multiple imbalances, 270–75

organ reserve in, 5–6

ovaries in, 61, 127–28, 142, 150, 156–57, 163, 272–73, 283

as thyroid misdiagnosis, 234–36, 243

Agnolyt, 137–38, 315, 320

Alaria, 174, 315

alcohol consumption, xvi, xviii, 52, 62, 87, 156, 194

limiting of, 1, 101, 135, 139, 165–66, 168, 171, 202, 219, 288, 292

aldosterone, 90, 215

function of, 94, 329

Alice in Wonderland, 255

allergies, allergens, in supplements, 38

allopregnanolone, 122, 125, 132

function of, 50, 329

allostasis, 77, 320

allostatic load index, 96

alternate-nostril breathing (Nadi Shodhana), 109

Alzheimer’s disease, 48, 80, 86–87, 212, 231, 244

amenorrhea, 92, 184–86, 187, 268

American Association for Clinical Chemistry, 242

American Association of Clinical Endocrinologists, 242

American Institute of Stress, 76

American Psychological Association, 76

amino acids, 3, 8, 17, 39, 93, 99, 104, 166

Amish, low obesity rate in, 168–69

AM/PM Perimenopausal Formula, 175, 195

Amy (patient), low cortisol in, 95–96

amygdala, 53, 62, 76, 83, 102, 263–64, 278, 320

hijack, 57, 115–16, 272, 281

anabolic hormones, 320

Androgen Excess and PCOS Society, 214, 225

androgen family, 46, 210–11

androgens, 19, 139, 320–21

balanced, 230

and cortisol, 276

and estrogen, 210

excess, see high androgens

and health problems, 205

in infertility, 34

levels of, 207

and viralization, 205–6

androstenedione, 208, 210–11

anemia, 222

anger, 127, 143

Annals of Behavioral Medicine, 266

anomia, 47

anorexia nervosa, 185, 187

anovulation, 127, 139, 161, 213, 215, 272, 320

PCOS and, 216

antecedents, 268

antidepressants, 7, 8, 58, 62, 112, 148, 197, 232, 234

adverse effects of, 12, 66

and cancer risk, 169, 196

as overprescribed, 65–66

antiestrogen medications, controversy over, 169–71

anti-inflammatories, 175, 225

anti-mullerian hormone (AMH), 183

antinuclear antibodies, 222

antioxidants, 173, 189

antipsychotics, 148

anti-thyroglobulin, 246, 321

antitransglutaminase antibodies, 186

antral-follicle count, 183

anxiety, xv, 9, 23, 39, 47, 48, 65, 89, 90, 95, 101, 104, 108, 110, 111, 112, 113, 119, 129, 147, 215, 259

estrogen levels and, 191–94

menstruation and, 138–39

progesterone levels and, 132, 135

U.S. rate for, 4

apathy, 78

apoptosis, 124, 161, 182, 321

appetite, low estrogen and, 179–80

Aristotle, 74

Arizona, University of, Center for Integrative Medicine, xix, 112

armour (dessicated thyroid hormone), 321

Armour Thyroid, 257, 258, 260

aromatase, 175, 208, 213

aromatization, 164

arrhythmia, 250

artificial light, 81

Ashramas, four developmental stages in, 64

ashwagandha (Withania somnifera; Indian ginseng), 110, 111–12, 314, 321

Asia, diet in, 171, 184, 188

Asian ginseng (Panax ginseng), 110–11, 193, 313, 317

Asparagus racemosus, 193

asthma, 114, 162

atherosclerosis, 185, 244

atrial fibrillation, 250

atrophic vaginitus, 4, 15

autoimmune conditions, 114, 222

autoimmune thyroiditis, see Hashimoto’s thyroiditis (autoimmune thyroiditis)

avoidance coping, 74

Ayurveda, 17, 110, 111, 138, 193, 202, 256, 287, 321

Ball, Lucille, 232

basal temperature, 245

behavioral disengagement coping (BDC), 103

Benson, Herbert, 106

Bezwecken, 118, 314

bi-est, 202

binding protiens, 239

biohacking, xx

bioidentical hormones, 10, 194, 202, 321

controversy over, 196–199, 201–2

for high cortisol, 114–15

in hormone balance, 3, 83

for low cortisol, 118

low dosage and short duration recommended for, 17, 100, 256, 291

media distortion of, 198

progesterone, 142–46

in three-step strategy, 17

vs. synthetic, 202–3

see also specific hormone imbalances

biomarkers, 321

BioResponse Nutrients, 173

bipolar disorder, 248

birth control pill (BCP):

advantages, 139–40

for contraception, 139, 140

disadvantages of, 140–41

for hormone balance, 8, 65, 128, 139, 225, 273, 275

for PCOS, 217, 220

bisphenol-A (BPA), 160–61, 171, 228, 245, 247, 268

Blackburn, Elizabeth, 84

black cohosh, 192, 195, 317

bladder infections, 199

bladderwrack (Fucus vesiculosis), 138, 256, 315

Bland, Jeffrey, xix

bloating, 6, 138–39, 144, 147, 153, 178, 185, 248, 250

blog, author’s, 14

blood clots, 113, 140, 141, 145, 152, 170, 197, 198

blood pressure, 72, 93, 94, 109, 110, 116, 118, 227

diastolic, 227

high, xix, 15, 20, 77, 82, 86, 102–3, 173–74, 219, 221, 228, 255, 266

low, 78, 88, 89, 92, 266

in men vs. women, 75

blood sugar, 72, 77, 79, 85, 93, 108, 110, 118, 163, 212, 223

blood tests, for hair loss, 222

blunted response, 78

body fat, 214–15

body mass index, 164, 171, 184, 191, 225

bones, 158

building of, 6, 207, 211, 229

weakening of, 82, 87, 95, 180, 185, 192, 249, 250, 281

botanicals (herbal therapies), 100, 321–22

appropriate subjects for, 40

cautions about adverse effects of, 40, 110, 111, 117

guidelines for, 39–40

for hormone balance, 3, 83, 109–13

inconclusive evidence for, 110–12

ineffective or unproven, 195–96, 256

procedure for adding, 40

regulation of, 36, 38

in three-step strategy, 17

see also specific hormone imbalances

Bowthorpe, Janie, 235, 259

brain:

cognitive function of, 20, 47, 63, 80, 86, 96, 108, 110, 114, 185, 203, 231

hemispheres of, 109

hormonal effect on, xx, 43, 50, 57

as hormone control center, 16, 45, 127, 182, 184, 237, 241, 263–64

imaging, 83, 232

injury, 92

middle-aged, 59

overactivated, 282

in perimenopause, 62–63

in puberty, 150

response to perceived danger by, 78

soothing of, 6, 50, 53–54

stress and, 76–77, 80

vigilance centers of, 52–54

brain chemicals (neurotransmitters):

“feel-good,” 8, 51, 59, 78, 81, 93, 112, 129, 136, 147, 150, 151, 180, 197, 270

in hormone balance, xx, 3, 8, 42, 43, 74–75, 90–91, 263–64

brain-derived neurotrophic factor (BDNF), 62, 63, 280

brain fog, xv, 4, 20, 47, 85, 152, 153, 166, 203, 236, 254, 266, 274

brain stem, 52, 101

BRCA 1 and 2 genes, 169

breast density, 169

breastfeeding, see lactation

breast tenderness, 47, 127, 129, 149, 152, 153, 200

breathing:

alternate-nostril, 109

deep, 87–88, 106, 112, 116

diaphragmatic (abdominal), 106

paced, 181

Brizendine, Louann, 64, 122

broccoli, 173

bruxism, 101

Buddha’s Brain (Hanson), 106

Buddhism, 108, 189

bulimia, 146, 185, 187

burnout, 88, 95, 173, 246, 286, 322

diagnosis of, 96–97

B vitamins, 3, 93, 100–101, 117, 141, 227, 266, 321

caffeine, 73, 86, 100, 115, 166, 265, 280, 296

and PMS, 147

weaning from, 101, 105, 119, 135, 147, 171, 188, 200, 288

calcium, 147, 315

California, University of:

at Berkeley, 198

at Los Angeles, 74

at San Francisco, xviii, 64, 84, 168

cancer, xix, 113, 132, 145, 191, 205, 212

bowel, 249

breast, xxi, 6, 12, 20, 47, 97, 107, 135, 141, 145, 155, 156, 158–59, 162–64, 165, 167–70, 171, 175, 184, 188, 191, 192–93, 195, 196, 197, 201, 219

celiac disease and, 249

cervical, 155

colon, 161, 162, 175, 198

endometrial, 122, 131–32, 155, 159, 170, 171, 175, 197, 219

environmental toxins in, 158–61

genetics in, 16, 141, 169, 195

low thyroid and treatment of, 248

obesity and, 162–63

ovarian, 97, 112, 140, 141, 167–68, 175, 196, 197, 216

PCOS and, 219

prevention, 135, 140, 175

prostate, 155

stress and, 23, 77, 270

telomeres and, 84

thyroid, 140, 251

canned food, 160, 161, 171, 228, 247

Cannon, Walter, 74

carbohydrates, 213, 223

refined, 164–65, 174, 293

cardiomyopathy, 250

case studies, 19

see also specific cases

Casey (case study), high androgens and PCOS in, 225–26

catabolic dominance, 322

catabolic hormones, 322

cataracts, 236

catecholamines, 63

catechol-O-methyltransferase (COMT), 62–63

Catherine (patient), 180–81

celiac disease, 185–86

and low thyroid, 248–50

cells, 173

binding proteins in, 237

breakdown and repair in, 6, 81

cortisol absorption by, 79

death of, see apoptosis

fat, 42, 153, 163

glucose in, 211

hormone levels inside of, 55, 129, 240

hormones and, 45

insulin resistance as serious problem for, 212–14

intestinal, 249

islet, 212

nerve, 63

red blood, 207

sensitive vs. numb, 270

stress and, 77

Centers for Disease Control (CDC), 165, 251, 255

cerebellum, 52

ceruloplasmin, 253

change:

being proactive in, xxi

stability through, 77

stages of, 297–98

strength-based approach to, 300–301

sustaining, xxi

chanting, 87, 102

Charlie’s Angels, xvii

analogy for estrogen, thyroid, and cortisol team, 44, 51–52, 130, 272, 290, 306, 307

Charlotte (case study):

on aging, 274–75

high cortisol in, 85–86

chasteberry (Vitex agnus-castus), 36, 50, 139, 195, 287, 314, 322

author’s experience with, 141–42

choice of, 137–38

for low progesterone, 136–38, 142

for PMS, 148

Cheryl (case study), high testosterone in, 209–10

childbirth, 97, 187

bleeding in, 92

gender rate in, 159

postpartum response to, 179

children:

of author, 63, 64

avoidance of herbal remedies for, 40

couples with, 75

and energy, 63

environmental toxins and, 161

iodine in, 174

mercury and learning disabilities in, 166–67

stress in, 103

stress in coping with, 58, 115, 119, 173, 281

trauma in, 93–94

vigilance and, 83

wanting more, 61, 65

chocolate, 62, 101

cholesterol, 90, 98, 133, 193, 200, 225, 231, 232

HDL (good), 86, 145, 192, 210, 229

LDL (bad), 192

sex hormones and, 45–46, 210

vitamin D and, 44

chromium picolinate, 226, 318

chronic fatigue syndrome (CFS), 95, 322

chronic stress response, 322

cinnamon, 229, 318

circadian rhythms, 54, 80–81, 247, 322

circulation, 53

Climara, 197

clitoris, 103, 180, 199, 200

enlarged, 206, 209–10

clomiphene citrate (Clomid), 226, 227, 228, 322

Cochrane Review, 199, 228

coldness, xvi

coleus, 256

collagen, 152

computerized axial tomography (CAT; CT), 322

conception, 123, 151, 229, 274

delayed, 140

hormone testing for, 7

congenital adrenal hyperplasia (CAH), 91, 215–16, 322

congestive heart failure, 250

conjugation, 154, 155

Conley, Chip, 277

constipation, 47, 255

Consumer Lab, 36–37, 39

copper, 247, 253, 266, 319

copper IUD, 140

corpse pose (Savasana), 88

cortex (thinking brain), 52–53, 76

corticosteroids, 114

cortisol, 19, 63, 98, 133, 156, 171, 215, 229, 231, 322

and aging, 78–82

bioidentical, 314

and DHEA, 193

in estrogen, thyroid, and cortisol team, 44, 51–52, 130, 272, 290, 306, 307

in estrogen dominance, 158

excess, see high cortisol

function of, 72, 79, 86, 329

ideal levels for, 32–33, 78–79

lack of, see low cortisol (hypocortisolism)

ligh/low, see dysregulated (high/low) cortisol

and low thyroid, 48, 290

as a major hormone for women, 42, 271

in multiple hormone imbalances, 276

in Pregnenolone Steal, 128–29

production in adrenals of, 5, 42, 76, 90, 128–29, 247

in reaction to threat and danger, 45, 51, 75–76, 94

release of, 5

and sex hormones, 48, 269

signs of balance in, 119–20

as stress hormone, 7, 42–43, 45–46, 49, 53, 71, 72–75, 129, 147, 215, 264, 269–70, 273

synthetic, 114

tests for, 32–33

cortisol awakening response (CAR), 80, 83, 323

cortisol resistance, 45, 50, 55, 62, 269–71

aging and, 79, 274

cosmetics, 159, 162

cotton, organic, 162

Council for Responsible Nutrition, 37

craziness:

hormonal issues dismissed as, 231, 234

sense of, xvi, 57, 59, 89–90, 119, 180, 278, 289

cues, for habit-forming, 296

CurcumaSorb, 175

Curcumax Pro, 175

Cushing’s syndrome, 82, 93, 325

cysts, 47, 122

breast, 128, 152, 177

ovarian, 206, 213; see also polycystic ovary syndrome (PCOS)

string-of-pearls pattern (Pearl Sign) in, 213, 216, 225

cytokines, 214

Cytomel, 257, 258, 259–60

dairy, 139, 164, 171, 224, 226, 227, 256

allergy to, 38

Dalton, Katharina, 141

dancing, 116–17, 266

Dandy Blend, 188

d-chiro-inositol (DCI), 227, 319

deafness, 246

DEHP, 161

dementia, 80, 198, 212

dental fillings, 255

depression, xii, xxi, 9, 23, 47, 48, 51, 86, 88, 95, 108, 111, 112, 114, 125, 138, 145, 148

androgens and, 209, 210, 219

estrogen and, 153, 180, 191, 192, 193, 196, 197

genetics in, 16

multiple imbalances in, 266

after stress, 62

thyroid and, 232, 244, 291

U.S. rate for, 4

DHEA (dehydroepiandrosterone), 19, 90, 94, 111, 193, 210, 215, 274, 276, 323

function of, 45, 208, 329

high cortisol and low, 114–15

and low energy, 229

DHEAS (sulfated dehydroepiandrosterone), 111, 114, 165

function of, 87, 329

diabetes, xix, 323

androgens and, 34, 212–13, 220, 227

cortisol and, 86, 270

environmental toxins and, 160–61

stress and, 23, 77, 270

type 2 (adult onset), 162–63, 213, 226

Diagnosis: Mercury (Hightower), 166

Diane (patient), xv–xvii, 6

diaphragmatic (abdominal) breathing, 106

diarrhea, 137, 185, 248

dichlorodiphenyltrichloroethane (DDT), 162

diet:

disordered, 8, 76

for estrogen control, 164–66, 184–85

excess fat in, 155, 156

gluten-free, 186, 249–50

Gottfried Protocol for, xvi, 8, 139, 337–38

for hair loss, 254

healthy, 87, 119, 260, 305, 306

for high androgens, 223–25, 226, 227

in hormone balance, xx, xxii, 8, 45, 112, 118, 216, 290

for iron, 254–55

for low estrogen, 188–89

no-white-stuff, xviii, 165, 293

Paleo, 164–65, 274

protein in, 224, 252

spiritual and psychological aspects of, 287

and weight maintenance, 286–88, 292, 293, 295

diet soda, 171

Dietz, Lillian Teubner “Mud,” as author’s inspiration, xi, xvii–xxi, 170, 305, 306, 307

digestion, 53, 72, 77, 93, 223, 231

dihydrotestosterone (DHT), 211, 221, 227, 252

function of, 330

Di-indolemethane (DIM), 172–74, 315, 323

diminished ovarian reserve (DOR; premature menopause), 156–57, 181, 182, 183, 186, 187, 188, 200, 269

diosgenin, 142

dioxin, 245

disease:

as focus of mainstream medicine, 13

prevention of, 11

stress and, 76, 78

diuretics, 122, 129, 152, 174

thiazide, 255

diurnal cortisol measurement, 80, 85, 115

diurnal cortisol panel, 32–33

diurnal cycle, 32, 49–50, 54, 80–82, 323

DNA, 168

damage, 100, 253

intercellular interaction between hormones and, 55

menopause and, 128

telomeres in, 84

doctors, practitioners:

as dismissive of women’s hormonal issues, xv, xvi, 6, 11, 31, 34, 67, 82, 89–90, 93–94, 96–97, 178, 183–84, 211, 231, 233–35, 241, 243, 261, 306, 334–35

duration of appointment with, 11

finding the right, 97, 235, 267, 306, 333–35

partnering with, xiii, xvi, xx–xxi, 16, 31, 97, 261, 265, 267, 304–5

perimenopause not understood by, 56

visionary, xix–xx

websites for, 335

when to consult, 19, 31, 32, 33, 39–40, 82, 99, 100, 112, 116, 118, 126, 130, 148, 166, 170, 179, 185, 196, 197, 200, 205–6, 214, 216, 219, 222, 229, 260, 261, 279

dong quai, 195

Donna (case study), progesterone cream use for, 143–44

dopamine, 62, 63, 78, 81, 93, 108, 112, 136, 147, 150, 291, 298, 323

double-blind trials, 323

downstream chemicals, 50

DQ2 gene, 249

DQ8 gene, 249

drosperinone, 140

Duhigg, Charles, 296

dwarfism, 246

Dweck, Carol, 293

dysregulated (high/low) cortisol, 32, 47, 48–49, 71–120, 269–70, 271, 275–76, 278–84

and low estrogen, 281–82

science of, 278–79, 280–81, 283–84

and sex hormones, 280–84

solutions for, 279, 282, 284

and thyroid, 278–79

dysthymia, 47

eczema (atopic dermatitis), 14, 323

egg donors, 183

eggs:

depletion of, 128, 133, 153, 156–57, 182–83, 188

maturation sequence of, 216

in PCOS, 216

production and release of, 59–61, 123, 124, 127, 157

electrolyte imbalance, 94

eleutherosides, 110

elimination, 53, 155, 164, 231, 243

Emotional Equations (Conley), 276

emotions:

mathematical formulas for, 277

and stress, 264

emWave HeartMath, 102

endocrine disruptors, 11, 99, 104, 128, 158–59, 244–45, 247, 253

in multiple imbalances, 268

see also environmental toxins

endocrine glands:

function of, 42, 45, 76, 236

hormones released by, 5, 186–87

see also glandulars, glandular therapy (natural dessicated thyroid); specific glands

endogenous, 323

endometriosis, 47, 122, 131, 145, 152, 187, 323

energy, xxii, 15, 19, 21, 43, 51, 77, 105–6, 174, 191

adrenal function in, 61

DHEA and, 229

false sense of, 52, 100

glucose and, 72

low, 7, 56, 61

thyroid function in, 43, 232, 237, 239, 262

environmental toxins, 11, 37–38, 49, 99, 158–62, 234, 237, 244–45, 268

effect on animals of, 159

everyday sources of, 159–62, 247

reducing exposure to, 161–62, 171, 245

Environmental Working Group, 160, 162

epidemiologists, 323

epigenetic effect, 168

epigenetics, xii, 323

epigenomics, 16, 168, 323–24

epinephrine (adrenaline), 62, 81, 91, 101, 112, 128, 298, 324

equations:

for fertilty, 284

for hormone combinations, 277

for PMS, 282

erectile dysfunction, 111

Erikson, Erik, 64

Estrace, 202

estradiol, 60, 154–55, 156, 177, 179, 199, 208, 282, 324

and cancer risk, 167

function of, 157, 330

levels of, 130, 152, 171, 183, 184–85, 189, 200

in perimenopause, 127–28

estradiol cream, 177, 180, 199–200, 202

estriol, 154, 156, 179, 199, 202

function of, 330

estriol cream, 199

estrogen, 19, 59, 63, 113, 231, 236, 264, 269, 276, 280, 298, 324

and androgens, 210

application of, 199–200

artificial, 153

in balance, 203–4

bioidentical vs. synthetic, 202–3

in conception, 7

in endometriosis, 131

in estrogen, thyroid, and cortisol team, 44, 51–52, 130, 272, 290, 306, 307

excess, see high estrogen

feminizing effects of, 121, 150–52, 178, 203

fluctuation of, 156–57, 167

food and, 184

function of, 42–43, 65, 121, 151–52, 330

ideal balance of, 177–78

lack of, see low estrogen

local application of, 199–200

as a major hormone for women, 42–43

mimicking of, see xenoestrogens

neurhormonal benefits of, 197

production and release of, 5, 42, 90, 121, 163–64, 215

-progesterone balance, 121–22, 123, 127–28, 130, 151–53, 178, 199, 203, 219; see also estrogen dominance

reasons not to take, 197

as sex hormone, 43, 48, 150

synthetic, 9, 195, 237

and testosterone, 208–9

types of, 154

estrogen, thyroid, and cortisol team, 44, 51–52, 130, 272

estrogen dominance (dysestrogenism), 122, 145, 213

background on, 152–54

cortisol-linked, 158

and low thyroid, 269, 283–84

science of, 154–71

seven root causes of, 156–58

estrogen family, 46

estrogen metabolites, 154, 156

estrogen (estradiol) patch, 176, 179, 197, 200, 201, 290

estrogen receptors, 152, 158, 167, 174, 191, 192, 199, 244–45

estrogen withdrawal, 197

estrone, 60, 154–55, 165, 179

function of, 330

evening primrose oil, 252

evidence:

importance of, 8–11

providing doctors with, 35

evidence-based integration, xx

exemestane (Aromasin), 169–70

exercise, xviii, xx, 45, 56, 57, 63, 66, 87, 99, 113, 168, 172, 174, 265, 295–96, 303, 305, 306

calming effect of, 54

dance, 116–17, 266

and LPD, 126–27

moderate or recreational, 8, 84–85, 147, 190, 224

and PMS, 147

strenuous or extreme, 103–4, 185, 187, 224

targeted, xvi, 17, 266, 290

for weight loss, 223, 293

youthfulness through, 84

fasting glucose level, 70, 86, 212, 214, 216, 222

fatigue, xv, 3, 4, 15, 23, 47, 48, 51, 52, 58, 78, 85, 89, 92, 94, 95, 96, 97, 98, 105, 110, 111, 112

estrogen and, 153, 193

mercury and, 166

multiple imbalances in, 265–66, 276, 278, 279

thyroid hormone and, 232, 237, 244, 248, 254, 279

fatty acids, 224, 252

Faulkner, William, 113

feedback loops:

between brain and hormones, 45, 237, 264, 291

in hormone interactions, 49–50, 77, 90, 157, 239, 241

negative, 124

Femal, 181

female androgenic alopecia (FAGA), 211, 228

Female Brain, The (Brizendine), 122

ferritin, 146, 222, 254–55

ferrous fumerate, 255

ferrous sulfate, 255

fertility:

BCPs in, 140

chasteberry for, 136–37, 314

equation for, 284

sex hormones and, 42, 157, 179, 182, 199, 205, 264

Fertility Blend, 137

fetus, 123

fiber, 155, 156, 171, 184, 189

content in foods, 223

fibroglandular volume, percent of, 169

fibroids, 47, 131, 144, 176, 178, 197

fibromyalgia, 95, 268, 324

fight-or-flight response, 53, 76, 88, 227

in men, 74–75

vs. relaxation, 107

fish, 252, 256

mercury in, 166–67, 171, 224, 255

wild vs. farm-raised, 224–25

fish oil, vii, xvi, 8, 36, 37, 39, 104, 105, 115, 224, 290, 313

flaxseeds, 189, 194

flexibility, 47, 51, 98

flushing, 152

focus, 128, 191

lack of, xv, 61, 170, 173, 179

yoga for, 107–8

folate, 166, 249

follicles, 123

hair, 221

follicle-stimulating hormone (FSH), 182, 187, 189, 200, 324

function of, 330

and LH, 215, 269

in perimenopause, 61, 157

as test for egg supply, 183

Food Addicts, 299

Food and Drug Administration (FDA), 36, 37, 38, 144, 170, 197, 202, 257n, 258, 259

food cravings, 19, 52, 72, 73

forest dwellers (middle-age), 64

Forest Pharmaceuticals, 257

forgiveness, 304

training, 102–3

formaldehyde, 162

4P Medicine: Predictive, Participatory, Preventive, and Personalized, xx

Free Androgen Index (FAI), 34

free radicals, 100

free-testosterone level, tests for, 34

fruits, 8, 174, 188, 223

FTO gene, 168

Fukushima, Japan, nuclear plant meltdown in, 251

functional medicine, xii, xix

Gail (case study), high cortisol in, 105–6

gallstones, gallbladder disease, xix, 197, 198

gamma-aminobutyric acid (GABA), 50, 122, 125, 132

gastric bypass, xxi, 292

gastroesophageal reflux disease (GERD), 324

gender identity, 205

genetics:

alteration of, 16

in breast cancer, 167–69

in high androgens, 214–15

hormone imbalance and, 49, 50, 71, 91, 98

in low thyroid, 247–48, 249

in menopause, 128

in miscarriage, 126

PCOS and, 218

in perimenopause, 62–63

in PMS, 282

see also DNA

genetic testing, 248

genome, 324

Georgia (case study), sex drive boot for, 201–2

Germany, integrative medicine in, 39, 136, 137–38, 192, 193

ghee (clarified butter), 193, 202

gingko, 112

ginsengs:

for high cortisol, 110–13

for low estrogen, 193

ginsenosides, 110

glandulars, glandular therapy (natural dessicated thyroid), 257–59, 324–25

insufficient evidence for, 114–15, 118, 229

gliadin, 186

glucocorticoid receptor resistance (GCR), 270, 276

glucocorticoids, 46, 71, 72, 267–68, 276, 324

stress and, 75, 93–94, 99, 270, 279

glucola, 214

glucose, 42, 43, 45, 122, 236

cortisol and, 72, 86

high, 211–12

and insulin, 213, 226, 228

glucose-to-insulin (G:I)ratio, 214, 226

glucuronic acid, 155

gluten, xvi, 185–86

allergy to, 38, 268

avoidance of, 188, 288, 293

and low thyroid, 248–50

gluten intolerance, 185–87

gluten sensitivity, 248–50

glycemic index (GI), 223

glycogen, 72

goiters, 246–47

goitrogens, 248

gonadotropins, 215

gonads, 186

Good Manufacturing Practices (GMP), 38

Gorney, Cynthia, 198–199

Gottfried, Sara:

case study of, 115–16

educational background and medical training of, xviii–xix, 3, 7, 89, 90, 107, 117, 150, 168, 184, 243, 257

epiphanies of, 308–10

hormonal imbalance of, 7–8, 17, 56, 63, 73–74, 89, 113, 130–31, 141–42, 253, 259, 286, 287, 299, 301–2, 306

integrative medical approach of, xii, xix–xxi, 3–4, 7, 12, 24, 93, 235, 239–40, 261, 265, 287–90; see also Gottfried Protocol

mother of, 260–61

vision and goals of, 306–7

Gottfried Protocol:

author’s development of, 7–8, 17

compliance vs. self-control in, 286–87

goals of, xvi, xvii, 286, 305–6, 310

by hormone imbalance, 313–18

integrative approach of, 3–4, 16–17

maintenance of, 289–90

making a plan for, 19

scientific basis of, 3–4, 10–11

three-step sequential strategy for, 17

see also specific hormones imbalances

grapefruit juice, 118

gratitude practices, 103

Graves’ disease, 244

Green Building Councils, 7

green tea, 104, 135, 171, 195

grieving, 113

Gross, Paul, 170

growth hormone, 19, 59, 81, 276

release of, 5

G-spot, 180

guided visualization, and PMS, 147

gut, 76, 105, 223, 247

bacteria in, 164

leaky, 249–50

habits:

maintaining change through, 295–97

tips in forming, 296

hair:

cortisol checked in, 83

dry, 243, 251

facial, 42, 47, 209, 215

healthy, 19, 229, 262

loss, xvi, 14, 114, 153, 183, 211, 220–22, 229, 241, 244, 251–52, 254, 260, 272

rogue, 206, 209, 211, 214, 215, 217, 218, 220, 225

Hanson, Rick, 106

Harvard Medical School, xi, xviii, 3, 8, 184, 186

Hashimoto’s thyroiditis (autoimmune thyroiditis), 174, 237, 246, 250, 251

Hawthorne effect, 324

headache, xii, 14, 96, 122, 135, 152, 153, 162, 173–74

health dashboard, 294

heart disease, xix, 90, 108, 160, 165, 185, 191, 201

androgens and, 205, 213, 223

hormone replacement and, 9, 197

and PCOS, 219, 220, 225

progestins and, 145

stress and, 23, 102

thyroid and, 244, 250

HeartMath methodology, 102

heart rate, 102, 104, 239

herbal teas, 135, 188

herbal therapies, see botanicals (herbal therapies)

herbology, 4

Hewlett-Packard, 102

high androgens, 205–30

bioidenticals of, 229

causes of, 214–16

Gottfried Protocol for, 207, 220, 222–29, 319

herbal therapies for, 228–29

and high estrogen, 208–9

and high insulin, 217, 220

and high insulin-high cortisol combination, 269

and insulin resistance, 211–14

lifestyle changes for, 222–29

and low progesterone, 48

and PCOS, 206–7, 218, 220

questionnaire for, 29–30, 34, 82

science of, 207–9

symptoms of, 47, 87, 207, 225–26

and viralization of women, 205–6

high cortisol, xv–xvii, 6, 20, 261, 271, 302

bioidentical hormones and, 114–15, 282

five mind/body practices for regulation of, 106–8

Gottfried Protocol for, 100–116, 282, 290, 313–14

herbal therapies for, 109–13

-high insulin-high androgen combination, 269

and low DHEA, 114–15

and low estrogen, 63, 269, 280

as most common imbalance in women, 32, 90, 280

in multiple hormone imbalances, 276

and progesterone, 49, 135, 280

questionnaire for, 24–25, 32, 71, 73, 280

science of, 76–88

seven health risks linked to, 86–87

symptoms of, xvi, 47, 52

testing for, 82–83

and thyroid, 148

high estrogen, 150–78, 271, 284, 302

background on, 152–54

bioidentical hormones for, 175

and cancer risk, 167–69

causes of, 154–67

controversial medications for, 170–72

dangers of, 122

Gottfried Protocol for, 171–77, 315–16

herbal therapies for, 174–75

and high androgens, 208

and low progesterone, see estrogen dominance

and obesity, 162–63

questionnaire for, 27–28, 33, 160, 166, 171

rate of, 33

science of, 154–71

symptoms of, 47, 122, 152–53, 173

Hightower, Jane M., 166–67

Hinduism, 64

hip fracture, 95

hippocampus, 53, 76, 102, 324–25

Hippocrates, 194

hirsutism, 217, 218, 225

holistic gynecology, xx

holistic health, xix, 15

homeopathy, and PMS, 148

homeostasis, xvii, 5, 40, 283, 289, 324

in allostasis, 77

see also hormone balance

hops (Humulus lupulus), 175, 193–94, 195, 316, 317

hormonal cloud (hormonal veil), 64–65

hormonal dysfunction, hormonal dysregulation, 13

hormone balance:

continuous improvement project for, 298–299

cultivating new habits for, 295–97

four phases to continual health in, 299–300

goal setting for, 291–93

ideal of, 19–21, 93, 119–20, 286–307

identifying strengths and weaknesses for, 300–2

mind-set for, 291, 293

new paradigm for, 11–14

patient’s responsibility in, xx–xxi, 13, 110, 242, 287

principles of, 15–16

in quest for optimal health, xii, 7, 22–23

self-tracking for, 291, 294, 300, 302–3

sense of well-being from, 51–52, 122, 203

sustaining change in, xxi, 286–307

tips for, 291–97

Hormone Cure, The (Gottfried), 18–21

how to use, 40–41, 303

hormone imbalance, xx, 213

author’s experience with, 7–8, 17, 56, 63, 73–74, 89, 113, 115–16, 130–31, 141–42, 150, 286, 301–2, 306

common causes of, 49

common combinations of, see multiple hormone imbalances

as contemporary issue, 308–10

as dismissed by mainstream medicine, xv, 6, 31, 34, 82, 89–90, 93–94, 96–97

evidence for, 8–11, 17, 41

finding root causes for, xxi, 8, 306

gender differences in, 4–5

identifying root causes of, 15, 55

importance of early intervention in, 13

in more than one category, 34–35

most prevalent, 46–47

new approach to, 277

serious consequences of, 6

symptoms of, 3, 4, 14–15, 23, 24–31

testing for identification of, xii, 3, 99–100, 118, 236, 237, 238, 239, 242, 245, 246, 250, 267

in younger women, 271

hormone receptors, 211

lock and key metaphor for, 45, 49, 125, 270

hormone-replacement therapy, 9–11, 142–43

cancer risk in, 141

controversy over, 196–199

estrogen dominance in, 158

media distortion of, 198

progesterone as essential in, 199

risks of, 141, 197, 198

scare over, 10, 65

smallest dose and shortest duration recommended for, 10, 17

see also bioidentical hormones

hormone resistance, 50, 55

hormones:

as allies, 18, 54

checking levels of, 54–55

as chemical messengers, 42

control systems of, 45–46

families of, 46

fluctuating levels of, 35, 45, 56, 65

functions of, 19, 329–32

importance of, 3–21

interaction among, 6, 34–35, 43, 45, 48–52, 57, 122–24, 263–83

inventory of, 302

job descriptions for, 42–44

in meat, 164

multitasking, 43–44

myths about, 19

precursors to, see precursor hormones (prehormones)

primer for, 42–55

science of, 19, 41

hormone tree, 46

hot flashes, 9, 15, 20, 61, 102, 113, 142

low estrogen and, 180, 184, 187, 189–95, 200, 281

testosterone and, 218

tips for, 181

HOW (honest, open-minded, and willing) Program, 200

human chorionic gonadotropin (hCG), 325

for attempted weight loss, 8–9

Humulus Lupulus Flower Extract 66:1, 175

hydrocortisone, 92, 118

hydroxylation, 154–55, 172

Hyman, Mark, xix–xx, 76, 213

hyperarousal, 76, 325

hypercortisolism, 82

as Cushings syndrome, 325

subclinical, 82

see also high cortisol

hyperplasia, 145, 197, 325

hypertension, 325

hyperthyroidism, 238, 248, 257

symptoms of, 250–51

hypervigilance, 325

hypocortisolism, see low cortisol (hypocortisolism)

hypoglycemia, 72, 325

hypogonadism, 186

hypopituitarism, 92, 186–87, 325

hypothalamic-pituitary-adrenal (HPA) axis, 76–78, 86–87, 90, 100, 101, 102, 268, 279, 325

hypothalamic-pituitary-gonadal axis, 268

hypothalamic-pituitary-thyroid (HPT) axis, 245, 247, 279

hypothalamus, 42, 53, 76–77, 127, 157, 187, 208, 237, 241, 264, 276, 325

hypothyroidism, 234, 238, 283, 325

overt vs. subclinical, 241, 243, 244

see also low thyroid hormone