Preface

Like all of the previous authors of this book, we are dedicated to the concept that immunology is best taught and learned in an experimentally based manner, and we have retained that emphasis with this edition. It is our goal that students should complete an immunology course not only with a firm grasp of content, but also with a clear sense of how key discoveries were made, what interesting questions remain, and how they might best be answered. We believe that this approach ensures that students master fundamental immunological concepts, internalize a vision of immunology as an active and ongoing process, and develop the ability to contribute to new knowledge, themselves. Guided by this vision, this new edition has been extensively updated to reflect the recent advances in all aspects of our discipline.

New Co-Author, Pat Jones

The new edition of Kuby Immunology welcomes a new member to our author team, Patricia P. Jones, who had been a contributing author to the seventh edition. Dr. Jones is professor of biology at Stanford University and holds the Dr. Nancy Chang Professorship in Humanities and Sciences. Having earned her undergraduate degree in biology from Oberlin College and her Ph.D. in biology, with a focus on immunology, from Johns Hopkins University, Dr. Jones did postdoctoral training at both UCSF and Stanford University School of Medicine before joining the faculty at Stanford. She and her research group have made fundamental contributions to our understanding of the genetics, structure, and expression of MHC class II proteins and of mechanisms regulating adaptive and innate immune responses. Dr. Jones has served in various leadership positions at Stanford, including chairing the Department of Biology and the Faculty Senate, and serving as vice provost for faculty development and diversity. She was the founding director of the Ph.D. Program in Immunology and currently holds the position of Director of Stanford Immunology, which oversees all immunology training–related activities at Stanford. Dr. Jones has taught students at all levels, including teaching for many years the basic molecular and cellular immunology course for undergraduate and graduate students at Stanford. Her dedication to teaching and her enthusiasm for immunology shine through in her work.

Understanding the Big Picture

Two of the most challenging aspects of teaching immunology are the many important details (cell types, proteins, interactions, and terminology) and the interconnected or circular nature of the response. We find that students often fail to recognize how these pieces work together in an immune response that is dynamic. Our primary goal in the eighth edition is to bring this big picture to the forefront by providing a map or scaffold that both faculty and students can refer to in order to draw regular connections between concepts and individual players in the immune response.

The first screen grab shows a figure titled Collaboration between Innate and Adaptive Immunity in Resolving an Infection. The corresponding text reads, Overview Figures-Figure 1-7 tracks the fundamental sequence of events that occur during an immune response, from infection through to pathogen clearance and the generation of memory. This figure provides an accessible overview of the immune response in Chapter 1, and serves as a contextual reminder in subsequent chapters. Figure 1-7 also includes callouts to the chapters in which each of the key processes included in the image are covered in greater detail. The second screen grab from a subsequent chapter shows a figure titled, B-cell Development begins in the bone marrow and is completed in the periphery. The figure seen in the earlier chapter is shown as a shadowed image and a part of it is zoomed out in the current figure. The shadowed inset is highlighted in a box. The corresponding text reads, In subsequent chapters, as relevant, an overview figure depicts the events discussed in that chapter, and it places those events in the context of the immune response by including an inset image from Figure 1-7, reminding students of where this new concept or area fits within the larger scheme of immunity.

Concepts and Context

The first screen grab shows the chapter opener photo with the chapter title and learning objectives listed beside it. The corresponding text reads, Learning Objectives-Each chapter begins with a set of suggested learning objectives that highlight the main points of that chapter. Instructors may use these to frame their coursework, or students may use them to gauge their understanding of the concepts covered in that chapter. While this list is by no means comprehensive, we imagine it as a starting place and we encourage instructors to use or modify these suggestions by articulating their own learning objectives, with an eye toward generating their own desired learning outcomes. The second screen grab shows Key Terms listed in the chapter. The corresponding text reads, Key Terms-Selected glossary terms from the chapter are listed on the first page as a preview of the important vocabulary. The third screen grab shows Key Concepts and Conclusion provided in each chapter. The corresponding text reads, Key Concepts-Each section in the text is followed by a bulleted summary list of Key Concepts. These encourage students to pause at the end of each section so they can reflect on and reinforce the content. Key Concepts-Each section in the text is followed by a bulleted summary list of Key Concepts. These encourage students to pause at the end of each section so they can reflect on and reinforce the content.

A Conceptual Approach to Signaling

Chapter 3 (Recognition and Response) now combines a description of the antigen receptors of innate and adaptive immunity with a brief introduction to cytokines, chemokines, and their respective receptors, formerly found in Chapter 4. Using a conceptual approach, Chapter 3 now foregrounds the major concepts required for understanding the processes of signal recognition and signal transduction throughout the immune system. We highlight the diverse roles of receptor diversity, multivalency, coreceptors, lipid rafts, and multiple signaling pathways in the regulation of immune responsiveness.

New Chapter—Barrier Immunity and the Microbiome

Research on the interaction between the microbiome and the immune response has flourished in recent years. Not only do our immune cells shape the diverse communities of microbes that live on our epithelial surfaces, but these communities have a powerful influence on the development and activity of a healthy immune system. The eighth edition of Kuby Immunology now includes a new chapter, Barrier Immunity: The Immunology of Mucosa and Skin (Chapter 13), that reviews our new understanding of the interaction between microbes and immunity at epithelial surfaces, including mucosal tissues and skin.

Advances in Immunology—Other Notable Updates

Immunology is a rapidly growing field, with new discoveries, advances in techniques, and previously unappreciated connections coming to light every day. In addition to a new chapter on barrier immunity, the eighth edition of Kuby Immunology has been thoroughly updated throughout, and now includes the following material and concepts.

• Natural killer (NK) cells are now recognized to be a subset of a larger group of innate lymphoid cells (ILCs) with characteristics similar to T_H cell subsets, but that originate in the myeloid lineage. ILCs are introduced in Chapter 2 and their roles in the innate and adaptive immune responses are discussed in Chapters 4 and 10, respectively.
• Exciting new immunotherapeutic approaches for treating a variety of conditions are described in Chapters 12, 15, 18, and 20.
• The role of the microbiome and its interactions with the immune system in health and disease is discussed in Chapters 1, 11, 13, 15, and 16.
• Insights gained from advanced imaging technology continue to be updated. For example, Chapter 6 describes immunofluorescence techniques that reveal changes in chromosomal organization accompanying V(D)J recombination.

New boxes have been added on the following topics:

• Classic Experiment Box 4-1: Discovery of Invertebrate Toll and Vertebrate Toll-Like Receptors
• Advances Box 5-2: The role of complement in the development of the nervous system and vision
• Evolution Box 6-3: The evolution of V(D)J recombination and RAG genes
• Clinical Focus Box 7-3: MHC expression and Tasmanian devil facial tumor disease
• Clinical Focus Box 10-2: Checkpoint inhibitors and cancer therapy
• Advances Box 10-4: Jumping genes, T_REG cells and the evolution of immune tolerance during pregnancy
• Advances Box 11-1: Tracking the movements of B cells between the dark and light zones of the germinal center
• Clinical Focus Box 12-1: Therapeutic antibodies for the treatment of diseases
• Advances Box 13-1: Cells involved in barrier immunity
• Clinical Focus Box 13-2: Communication between the gut and the brain
• Advances Box 13-3: Germ-free animal model systems
• Clinical Focus Box 17-1: Zika virus and vaccine development
• Advances Box 18-2: Broadly neutralizing antibodies to HIV
• Clinical Focus Box 19-2: CAR-T cells as a potential cancer cure

LaunchPad for Kuby Immunology

The eighth edition of Kuby Immunology is fully supported in LaunchPad. We designed LaunchPad as a resource to help students achieve better results. Our goal was to increase their confidence by providing a place where they could read, study, practice, complete homework, and succeed. In addition, LaunchPad always provides instructors and students with superior service and support, based on Macmillan’s legendary high-quality content. LaunchPad includes a suite of supplements that build on the text by engaging students inside and outside the classroom.

In-Class Activities—In many classrooms, student engagement is key to addressing misconceptions and reinforcing important concepts. The Kuby Immunology authors have provided instructions and materials for a variety of activities they use in their own classrooms to engage students. These tried-and-true activities range in length and complexity and can serve as a springboard for active learning in the classroom.

Case Studies—Interpreting experimental data is essential in understanding immunology. These case studies explore immune function, disease, and treatment through the application of primary research and data. Students are led through a series of experiments and challenged to interpret the data and draw conclusions. By integrating experimental techniques from immunology, molecular biology, and biochemistry, these case studies teach students to think critically and synthesize their knowledge of immunology and other branches of science.

Animations—Many of the most difficult topics in immunology are multistep events that are best visualized through animations. We have created a suite of 2D animations for the eighth edition that walk students through these difficult topics, showing each step of the process. Each animation is accompanied by assessments.

Videos—Dynamic imaging techniques allow immunologists to observe the immune system at work in vivo. These striking videos show a T cell crawling along a network of stromal cells, the change in behavior when a naïve B cell is activated, and the chemotactic response of neutrophils to a site of damage.

Learning Curve—LearningCurve adaptive quizzing offers individualized question sets and feedback for each student based on his or her correct and incorrect responses. All the questions are tied back to the e-Book to encourage students to use the resources at hand.

e-Book—The Kuby Immunology, Eighth Edition, e-Book is available through Vital Source and LaunchPad. This fully enhanced e-Book includes embedded animations and videos, as well as web links to additional resources. e-Book access can be purchased through the Macmillan Student Store and represents a significant cost savings versus a printed copy of the book.

Advanced Online Material—Feature boxes within the text describe clinical connections, classic experiments, technological advances, and evolutionary aspects of the immunology topics discussed. Boxes and other content that have been retired from the print text are available for instructor download at the catalog site.

Test Bank—The Kuby Immunology test bank has been expanded to include more higher-order questions in both multiple choice and short answer formats. Over 700 dynamic questions in PDF and editable Word formats are rated by level of difficulty and Bloom’s taxonomy level, and tagged to specific sections of the text.

Optimized Art—Fully optimized JPEG files of every figure, photo, and table in the text are available, featuring enhanced color, higher resolution, and enlarged fonts. Images are also offered in PowerPoint format for each chapter.