Implementing tick bite prevention strategies is crucial, but equally important is knowing when to administer prophylaxis — that is, a measure taken to prevent disease. Prophylactic measures can be initiated by anyone immediately after finding a tick bite, and they can be used regularly by people at high risk for tick bites. This chapter explores the importance of prophylaxis, identifies which herbal formulas can be used as prophylaxis for which types of tick bites, and examines the herbs used to make the formulas.
I believe that prophylaxis is important because it can be so difficult to diagnose Lyme and other tick-borne disease (TBD) properly. Prophylaxis allows you to take measures to treat illness preemptively, before it even manifests as symptoms in your body. The philosophy is not unique to tick-borne diseases. For example, people who are going to visit regions where malaria is endemic are encouraged to take a prophylactic pharmaceutical regimen, before they travel, to protect themselves just in case they are bitten by a mosquito that transmits the protozoan that causes malaria. Better to treat ahead of time rather than wait for symptoms and diagnosis.
The same holds true for Lyme and other TBD. Whether you are bitten by a tick or simply living, working, or recreating in an area where these diseases are endemic, you can take measures to prevent infection with these diseases. My preference for the prophylactic approach is based on several factors regarding Lyme and TBD diagnostics:
With such ambiguity and a lack of easy and accurate detection, prophylaxis is the best way to protect yourself against the development of TBD. Starting herbal antibiotic prophylaxis immediately after a tick bite (or having it already in your system — see the following discussion of prophylaxis for high-risk populations) activates the immune system and initiates an antimicrobial response that will help destroy any pathogens that may be transmitted to you from the tick.
I prefer herbal antimicrobials over pharmaceutical antibiotic prophylaxis for a number of reasons. First, antibiotics only kill bacteria. Some TBDs, being protozoa or viruses, require different treatments. The herbal prophylactic formulas are designed to address all possible pathogens carried by a specific tick. Unlike pharmaceutical antibiotics, which often contain just one chemical compound that is engineered to kill certain classes of bacteria in a certain way, plants are complex and have many chemical compounds that synergize in favor of our bodies and against the pathogens. Herbs help our immune system function better in the face of tick-borne pathogens, do not negatively impact gut flora, have fewer side effects, and are safe to take long-term. At this stage of treatment, when there is no known infection, I recommend avoiding pharmaceutical use and opting for a prophylactic herbal approach. (It’s safe to take both a pharmaceutical antibiotic and an herbal antimicrobial formula at the same time.)
The prophylactic herbal antimicrobial formulas in this book are designed to target specific pathogens. While the most common tick-borne disease in the United States is Lyme disease, caused by Borrelia burgdorferi, other tick-borne pathogens must be prevented, too. As we reviewed earlier, there are many different types of ticks, and each can carry various pathogens. By looking at the geographic area in which you reside, work, or visit, you may determine which ticks are endemic and, therefore, for which pathogens you are at risk.
Every state and province in the United States and Canada has at least one tick species native to its landscape that causes human disease (see the chart). So everyone is at risk for a tick bite, but some people are at higher risk than others. Some occupations and hobbies lend themselves to higher tick exposure. Spending more time in tick habitat increases the likelihood of a tick bite, and therefore tick-borne disease.
Occupations and pastimes in which you are consistently exposed to prime tick habitat or in contact with animals that are consistently exposed to prime tick habitat increase your risk for a tick bite. They include:
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If you fall into any of these categories, you may want to take additional precautions during tick season. This may include taking an herbal tick bite formula prophylactically — and not only as a response to a tick bite to ward off the potential transmission of TBD, but as part of your daily routine, under the assumption that you will be bitten by a tick at some point, and as noted above, many people who are diagnosed with TBD do not remember ever receiving a tick bite.
Taking an herbal antimicrobial formula daily prepares your immune system for defense against your likely exposure to TBD. For example, if you live in an area where Lyme disease is prevalent and you spend a great deal of time in prime tick habitat, you might take the prophylactic tick-bite formula designed for deer ticks during high tick season. If you are then bitten by a deer tick infected with Borrelia burgdorferi, whether you are aware of the tick bite or not, the herbs have already activated your immune system and a targeted antibacterial mechanism is already at work in your body in order to decrease your chance of becoming infected. This approach allows for the earliest intervention.
As you’ll see in the formulas later in this chapter, the dosage for the use of the prophylactic herbal formulas as TBD prevention for high-risk populations is less than the dosage you would take after a known tick bite. The lesser dosage arises from the expectation that the formula will have more of an impact on the incoming pathogens from a tick bite because it will already be in your system. It is safe to take these herbal formulas long-term.
It’s important to take the formula that is appropriate for your geographical location. To determine which one(s) are appropriate for you, refer to chapter 1. Consult the maps that display the location of each tick species to determine which ticks pose you the most risk. Confirm that information for your specific location by checking in with your local department of health or cooperative extension office to find out which ticks are transmitting diseases locally. Then look up the formula specific to those particular ticks in the section following.
For example, a farmer in Vermont would consult the maps of tick location and find that deer, brown dog, American dog, and lone star ticks can be found in that state. When the farmer reaches out to the local department of health or agricultural extension office, she or he would find that 99 percent of tick-borne disease in Vermont is transmitted by the deer tick. Historically, the brown dog tick has not transmitted any pathogens in Vermont. At the time of this writing, American dog ticks do not carry disease in Vermont, and although the lone star tick has been reported in Vermont, it is not considered to be established there. So, if the farmer, whose occupation carries a high risk for tick exposure, wishes to protect her- or himself against tick-borne disease, the tick to focus on would be the deer tick, as the primary vector of Lyme disease, and the farmer could take the formula designed for deer tick bites.
The prophylactic tick bite formulas that I use in my practice arose from a collaboration with longtime herbalist Bonnie Bloom of Blue Crow Botanicals in western Massachusetts. Drawing from my clinical experience, Bonnie’s herbal expertise, and the research of master herbalist Stephen Harrod Buhner, I first designed an herbal formula to target the pathogens commonly carried by deer ticks, which are widespread in the Northeast, where I practice. After observing the effectiveness of this formula with my patients, I went on to design a series of prophylactic formulas targeting a range of pathogens carried by ticks across the United States and Canada today.
The key herbs used in the prophylactic formulas are discussed in more depth beginning here. They each have specific antimicrobial actions. Their combined effects create immune modulation.
These prophylactic tick bite formulas are multi-herb tinctures — that is, alcohol-based extracts of specific herbs used in combination. In the Resources section, you’ll find details on some trustworthy suppliers from whom you can buy good-quality tinctures. A couple of them offer these exact multi-herb formulas; others offer single-herb tinctures that you can combine in the ratios given in the formulas. If you want to make your own tinctures, the Resources section also offers details on which companies are the best sources for herbs.
The dosage of these formulas depends on what you are using them for. If you are at high risk for a tick bite and want antimicrobial protection during tick season (for deer ticks, whenever outdoor temperatures are above 28°F/−2°C), you will need only about half the usual dosage to discourage tick-borne pathogens from establishing an infection.
If you receive a tick bite, prophylactic treatment calls for the full dosage. In addition, I recommend using a natural biofilm buster like serrapeptase at 120,000 units (or 500 mg) twice daily on an empty stomach; see the herbal prophylactic protocol in chapter 5 for more details.
The formulas should be taken on an empty stomach, which means 30 minutes before food and 2 hours after food. If you are unable to use alcohol-based herbal extracts, Woodland Essence (see Resources) has each of the single herbs used in the tick bite formulas available as a glycerite (a glycerin-based herbal extract), except for andrographis. Consult a trained holistic health-care professional if you plan to take a tick bite formula for more than 3 months for further guidance on dosing, side effects, drug interactions, contraindications, and pertinent medical history.
I refer to the plants used in the prophylactic formulas by their Latin name, rather than their common name, because it is a more specific identifier. Plants can have multiple common names, and a common name can be used for more than one plant. Houttuynia cordata, for example, can be called houttuynia, chameleon plant, or bishop’s weed, among other common names. And the common name sage can be used to refer to many of the plants in the Salvia genus, including the species Salvia miltiorrhiza, which I use in some of the prophylactic formulas. In contrast, the Latin name designates just a single species. |
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Latin Name |
Common Name |
---|---|
Andrographis paniculata |
Andrographis |
Cordyceps militaris |
Cordyceps, orange caterpillar fungus |
Cordyceps sinensis |
Cordyceps |
Cryptolepis sanguinolenta |
Cryptolepis |
Houttuynia cordata |
Houttuynia, chamelon plant, bishop’s weed |
Polygonum cuspidatum |
Japanese knotweed |
Salvia miltiorrhiza |
Red sage, dan shen |
Scutellaria baicalensis |
Chinese skullcap |
Preventive dosage for high-risk populations: Take 1⁄2 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, during tick season.
Dosage after a known tick bite: Take 1 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, for 30 days. Also take 120,000 units (or 500 mg) of serrapeptase twice daily on an empty stomach.
Target pathogens: Borrelia burgdorferi, B. mayonii, B. miyamotoi, Babesia species, Anaplasma phagocytophilum, Ehrlichia muris eauclairensis, and Powassan virus
Note: I use a different prophylactic protocol for deer tick bites in children.
Preventive dosage for high-risk populations: Take 1⁄2 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, during tick season.
Dosage after a known tick bite: Take 1 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, for 30 days. Also take 120,000 units (or 500 mg) of serrapeptase twice daily on an empty stomach.
Target pathogens: Rickettsia rickettsii and Francisella tularensis
Preventive dosage for high-risk populations: Take 5⁄8 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, during tick season.
Dosage after a known tick bite: Take 11⁄4 teaspoons of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, for 30 days. Also take 120,000 units (or 500 mg) of serrapeptase twice daily on an empty stomach.
Target pathogens/diseases: STARI, Ehrlichia chaffeensis, E. ewingii, Heartland virus, Francisella tularensis
Preventive dosage for high-risk populations: Take 1⁄2 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, during tick season.
Dosage after a known tick bite: Take 1 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, for 30 days. Also take 120,000 units (or 500 mg) of serrapeptase twice daily on an empty stomach.
Target pathogen: Rickettsia rickettsii
Preventive dosage for high-risk populations: Take 1⁄2 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, during tick season.
Dosage after a known tick bite: Take 1 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, for 30 days. Also take 120,000 units (or 500 mg) of serrapeptase twice daily on an empty stomach.
Target pathogens: Rickettsia parkeri and Ehrlichia chaffeensis
Preventive dosage for high-risk populations: Take 5⁄8 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, during tick season.
Dosage after a known tick bite: Take 11⁄4 teaspoons of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, for 30 days. Also take 120,000 units (or 500 mg) of serrapeptase twice daily on an empty stomach.
Target pathogens: Rickettsia rickettsii, Francisella tularensis, and Colorado tick fever virus
Preventive dosage for high-risk populations: Take 1⁄2 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, during tick season.
Dosage after a known tick bite: Take 1 teaspoon of tincture in water three times a day, 30 minutes before breakfast, lunch, and dinner, for 30 days. Also take 120,000 units (or 500 mg) of serrapeptase twice daily on an empty stomach.
Target pathogens: Borrelia hermsii, B. parkeri, and B. turicatae
In this section, we will focus on the tincture used to treat deer tick bites, which is the prophylactic formula we use most commonly in my practice. You could use these instructions as a template for making the other tick bite formulas as well.
A tincture is an alcohol extract of dried or fresh plants with medicinal properties. The alcohol is part of the menstruum, the liquid solvent that pulls active constituents from the plants soaking in it. The alcohol makes up a specific percentage of the menstruum, while the rest is made up of water and sometimes a small amount of apple cider vinegar. To prepare a tincture, you must know the ratio of the total weight of herbs to the volume of the menstruum. For the deer tick bite formula, we will use a ratio of 1:5 for dried plants and 1:2 or 1:3 for fresh plants:
I have deep appreciation and respect for Bonnie Bloom’s work as an herbalist. She has humbly given me permission to share her instructions on how to make deer tick bite formula. Making this formula is not simple! To obtain the level of medicinal value I expect in a formula like this, I recommend that you either follow these directions exactly or purchase the tinctures from a trusted source.
Supplies
Herb |
Plant Part |
Weight to Volume |
Menstruum Proportions |
---|---|---|---|
Cryptolepis sanguinolenta |
Dried root |
1:5 (or possibly 1:7; see the instructions in part 1) |
60% alcohol, 35% spring water, 5% apple cider vinegar |
Houttuynia cordata |
Fresh aerial parts (preferred) |
1:2 |
65% alcohol, 35% spring water |
Dried aerial parts (if that’s all that is available) |
1:5 |
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Polygonum cuspidatum |
Fresh root |
1:3 |
50% alcohol, 50% spring water |
Dried root |
1:5 |
60% alcohol, 40% spring water |
|
Uncaria tomentosa |
Dry bark |
1:5 |
60% alcohol, 35% spring water, 5% apple cider vinegar |
Dried herbs are frequently tinctured in a 1:5 ratio of herb weight to menstruum volume. Houttuynia is best tinctured from fresh plant material (see part 2), but if you must use dried houttuynia, follow the procedure described here. For our purposes, tincture each herb separately.
For tincturing fresh herb matter, we use a 1:2 or 1:3 ratio of plant weight to menstruum volume.
See the formulas earlier in this chapter for the appropriate tincture ratios. For the deer tick formula, you’ll combine Cryptolepis sanguinolenta, Houttuynia cordata, Polygonum cuspidatum, and Uncaria tomentosa tinctures in a 1:1:1:1 ratio — that is, in equal parts. (Though if you have slightly more or less of one or two herb tinctures, it will not change the overall efficacy of your extract.)
Let’s take a look at the herbs used in the prevention and treatment of acute tick-borne illness in more detail, particularly those used in the tick bite formulas and to treat acute Lyme disease. Each plant has numerous constituents that work together in various ways to allow your immune system to better kill tick-borne pathogens. For this reason, I recommend the use of whole herbs, not isolated constituents extracted from herbs.
Each plant has numerous constituents that work together in various ways to allow your immune system to better kill tick-borne pathogens.
Common name: Andrographis
Andrographis is an extremely bitter herb that has been used for two thousand years in the traditional herbal medicine of India.
Andrographis kills Borrelia species and is used for the treatment of acute Lyme disease. It has potent anti-inflammatory effects and inhibits the inflammatory cytokines that become activated with Lyme disease. It improves macrophage and neutrophil activity. It protects the heart, improves liver function, and protects the liver. Because it can cross the blood-brain barrier, it kills Borrelia in the brain and protects neural and glial cells. Andrographis also relieves joint inflammation and swelling, prevents cartilage destruction, and has antiviral action.
Because it kills Borrelia species, andrographis is also useful as prophylaxis for Ornithodoros tick bites; Borrelia is the only pathogen these ticks are known to carry.
Like most plants, andrographis contains many active constituents. Andrographilides is the most popular and most researched constituent, and therefore you will often find a standardized extract of 10 percent andrographilides. However, since all constituents in the plant are beneficial, I recommend using the whole plant.
The main side effects that may occur from using andrographis are possible gastrointestinal discomfort, constipation, dizziness, palpitations, or skin reactions. A rare side effect is a temporary loss of taste. Do not use if you are pregnant, if you are trying to become pregnant, or if you have active gall bladder disease. Do not use if you are taking isoniazid, theophylline, or immunosuppressants (e.g., cyclosporin). A very small percentage of people are allergic to andrographis. An allergic reaction would manifest as hives (an itchy skin rash); swelling of the mouth, lips, tongue, or throat; or wheezing or difficulty breathing. If you experience an allergic reaction, discontinue using the herb, and consider using diphenhydramine (Benadryl) or seeking medical attention.
Common name: Cordyceps
The common name cordyceps applies to two species that can be used interchangeably in the tick bite formulas and tick-borne disease treatments: Cordyceps sinensis, a brown-orange fungus native to higher altitudes of Asia, and C. militaris, a species more commonly known as orange caterpillar fungus.
Cordyceps has been used for thousands of years in the traditional medicinal practices of Tibet. It protects the liver, brain, and heart, has antibacterial and antiviral properties, and has adaptogen-like effects on the immune system and mitochondrial activity. Cordyceps is specifically effective as a cytokine modulator in Rickettsia treatment. It is also rich in amino acids, fatty acids, minerals, and vitamins.
Cordyceps occasionally causes dry mouth or gastrointestinal discomfort. It has a synergistic effect with cyclosporin A and antidiabetic medications.
Common name: Cryptolepis
Cryptolepis is a broad-spectrum antimicrobial herb used in the prophylaxis and treatment of babesiosis. A climbing perennial with thin stems, cryptolepis has been used for hundreds of years in Africa for the treatment of malaria and for thousands of years in Asia for various ailments.
Cryptolepis is immune modulating, anti-inflammatory, analgesic, fever reducing, and protective to the heart and the liver. It also has antiviral action and is incredibly effective against malaria. One study showed that mice given cryptolepis before being infected with malaria were protected against the disease.46 I offer the extrapolation of this principle in support of using cryptolepis for the prevention of babesiosis with the herb’s inclusion in the deer tick bite formula.
The only noted side effect is a possible elevation in alkaline phosphatase and uric acid that resolves upon discontinuation with no adverse effect. These side effects have no clinical significance.
Common name: Houttuynia
Houttuynia is an invasive rhizomatous perennial that grows as ground cover in moist areas. It is an antimicrobial herb used to target Anaplasma, Powassan virus, and Ehrlichia in the deer tick bite formula, and it can also be used to target Rickettsia, Bartonella, Heartland virus, and Colorado tick fever virus.
Houttuynia has been shown to increase anti-inflammatory cytokines and decrease inflammatory cytokines in the immune system. As herbalist Stephen Buhner writes, houttuynia “inhibits viral replication, interferes with the function of the viral envelope, is directly virucidal, stops virion release from infected cells, and prevents viral infection if taken prophylactically.”47 As a result, houttuynia is included in tick bite formulas targeted at ticks that carry Powassan virus, Heartland virus, and Colorado tick fever virus. Houttuynia also has analgesic, antifungal, and antioxidant characteristics.
The main side effect that may occur with houttuynia is nausea due to the herb’s fishy smell and taste. Do not take during pregnancy.
Common name: Japanese Knotweed
Japanese knotweed is another significantly important herb used to treat borreliosis and specifically Lyme disease. It is a leafy, bamboo-like perennial plant that grows and spreads easily. Japanese knotweed has been used as medicine in Asia for thousands of years. It is an invasive species in the United States, since it has been difficult to eradicate since its introduction in the early 1800s; in fact, some states now prohibit the live plant from being distributed or cultivated within their borders. Root harvesting is best done in spring or fall, although the process is challenging due to its deep root system and ease of sprouting.
Japanese knotweed counteracts the effect Borrelia has on the immune system. Knotweed blocks the cytokine-stimulated inflammatory response that is triggered by Borrelia, which weakens Borrelia’s effect on us and strengthens our immune system’s effort to eradicate it. It has an anti-inflammatory effect on the joints and protects the heart. Japanese knotweed is very effective in treating neurological manifestations of Lyme disease, since it crosses the blood-brain barrier. Therefore, it is able to act as an antibacterial, anti-inflammatory, and antioxidant and has a calming effect in the brain and central nervous system. Japanese knotweed also protects endothelial cells that line blood vessels, creates blood vessel growth, and increases blood flow to the eyes, heart, skin, and joints. The plant has been shown to be a mild biofilm buster, decreasing the formation of biofilm and the amount of bacteria inside the biofilm. It also has antifungal and antiviral properties. In addition to treating Lyme disease, Japanese knotweed kills Bartonella species.
At least 67 constituents have been identified in Japanese knotweed. Resveratrol, which is abundant in this plant, is the most researched and widely used. Resveratrol is an antioxidant that improves neuromuscular coordination, learning, and memory; it protects the mitochondria and increases cerebral blood flow and oxygen to the brain. It also reduces inflammation (including joint inflammation) and protects cartilage. Red wine is another source of resveratrol. For the purposes of borreliosis prevention and treatment, I recommend using the whole herb instead of resveratrol alone. As noted above, the whole herb is generally preferable to an isolated constituent, and there are many other known chemical compounds found in knotweed that are effective against borreliosis. For example, like resveratrol, the polydactin, emodin, stillbenes, and anthraquinones in Japanese knotweed have a neuroprotective effect. Polydactin also protects the heart.
The main side effect from using Japanese knotweed is possible gastrointestinal discomfort. A rare side effect is a temporary loss of taste. Do not use if you are pregnant, if you are trying to become pregnant, while taking anticoagulants, or before surgery.
Common name: Red Sage
Red sage, also known as dan shen, is a perennial shrub with dark green leaves and whorls of purple-blue flowers that is native to China and Japan. It has been used in Chinese medicine for over two thousand years. Like Chinese skullcap, red sage has potent adaptogen-like activity for cytokines, meaning that if the cytokine activity is high, it will lower it, and when cytokine activity is too low, it will raise it, according to what is best for the human body. This is especially helpful when the immune system is faced with an infection.
Red sage is especially effective as a cytokine modulator in Rickettsia treatment. (It inhibits COX-2, interleukin-17, and prostaglandin E, in this way working against the effects by which Rickettsia takes over the immune and endothelial systems.) It protects endothelial cells and gut mucosa as well as mitochondria, the spleen, the liver, and the heart. It also protects the Golgi apparatus (an organelle involved in intracellular transport, among other things), especially in brain cells, which can help prevent neurodegenerative disease.
Red sage is an anticoagulant and should not be used with anticoagulant medications, if you have a bleeding disorder, or before surgery. It also inhibits the CYP3A4, CYP2C9, CYP2E1, CYP2D6, and CYP1A2 enzymes found in the liver, which are essential for the metabolism of certain medications. Since the herb inhibits these enzymes, this means that less medication is broken down and therefore more medication remains in the system. There is a long list of medications, called CYP3A4 substrates, that are affected by red sage, including acetaminophen, some antibiotics, statin drugs, many psychiatric drugs, opioids, some chemotherapeutic drugs, and immunosuppressants. CYP2C9, CYP2E1, CYP2D6, and CYP1A2 substrates are also affected by red sage. In rare cases, red sage can stimulate an allergic reaction. Do not use if you are pregnant.
Common name: Chinese Skullcap
Chinese skullcap — not to be confused with American skullcap (Scutellaria lateriflora) — is a shrub with blue-purple helmet-shaped flowers that grows in sandy, moist areas. It is native to East Asia.
The root of Chinese skullcap has antibacterial, antiviral, and antifungal properties. It has an affinity for the brain, where it reduces inflammation, acts as an anticonvulsant, regulates sleep, stimulates brain tissue regeneration, and protects the neurological system. It blocks the pro-inflammatory cytokines that have been implicated in tick-borne diseases and protects the mitochondria.
Chinese skullcap has adaptogen-like effects on cytokine activity in Rickettsia treatment. As a way of survival, Rickettsia interacts with the human immune system to keep the level of several cytokines low enough that the bacteria can survive but high enough to keep its host alive. Chinese skullcap modulates the immune system in favor of the human body. If cytokine activity is high, it will lower it, and when cytokine activity is too low, it will raise it. (In particular, Chinese skullcap inhibits COX-2, p38 MAP kinase, and prostaglandin E2 and downregulates interleukin-17.) These actions work against Rickettsia as it tries to take over the immune and endothelial systems. Chinese skullcap is also effective in the treatment of Lyme disease.
Chinese skullcap can sometimes cause gastrointestinal discomfort. It also inhibits the CYP3A4 enzyme found in the liver, which is essential for the metabolism of certain medications. Since the herb inhibits the enzyme, less medication is broken down and therefore more medication remains in the system. There is a long list of medications called CYP3A4 substrates that are affected by Chinese skullcap, including acetaminophen, some antibiotics, statin drugs, many psychiatric drugs, opioids, some chemotherapeutic drugs, and immunosuppressants. One of Chinese skullcap’s constituents, oroxylin A, improves the efficacy of certain anticancer drugs by inhibiting the P-glycoprotein-mediated efflux pump. Chinese skullcap also increases the effect of ribavirin, albendazole, ciprofloxacin, and amphotericin B. Do not use if you are pregnant.
Serrapeptase, or serratiopeptidase, is an enzyme that was isolated from the bacterium Serratia that lives in the intestine of the silkworm. It has anti-inflammatory and anticoagulant properties. Most important, it has the ability to break down the matrix of biofilm that Borrelia and other tick-borne pathogens create around themselves. In conjunction with other pharmaceutical and/or herbal antibiotic strategies, a biofilm buster like serrapeptase is of utmost importance in eradicating the disease. It has been shown to be synergistic with some antibiotics.
Because serrapeptase is an anticoagulant, do not take it before surgery, with anticoagulant medications, or if you have a bleeding disorder.
Common name: Cat’s Claw
Cat’s claw, or uña de gato, is a woody vine with clawlike thorns. It is one of the most important herbs used to treat Borrelia infections, especially Lyme disease.
There are two species of Uncaria used in the treatment of Lyme disease. Uncaria tomentosa is well known and well researched. It is the species indicated in the tick bite formulas for prophylaxis of borreliosis. It is especially effective in preventing Lyme disease from taking hold in the body due to its effect on the immune system. Therefore, it is a key herb to use in prophylaxis. U. tomentosa is also effective as an anti-inflammatory in the joints, which may be painful or swollen in acute Lyme disease, as well as persistent Lyme disease (which is not covered in the scope of this book). Antiviral and antioxidant are other actions of U. tomentosa that are relevant to its use in preventing and treating acute tick-borne disease. It has been used by people living in the Amazon for thousands of years.
U. rhynchophylla is used to treat acute Lyme disease as well as persistent Lyme disease. U. rhynchophylla is especially effective when Borrelia has penetrated the blood-brain barrier. It has an anti-inflammatory and antiseizure effect on the brain, and is considered an excellent protector of the neurological system. Studies have shown that it works in numerous ways specifically in the brain: decreasing swelling, improving memory, improving learning, decreasing inflammation, protecting neurons, decreasing seizures, improving demyelination, increasing microglia (the connective tissue of the brain), and moderating aggression. Other relevant actions of U. rhynchophylla are that it is an antiviral and systemic tonic. It has been used in China for thousands of years.
U. tomentosa contains pentacyclic oxindole alkaloids (POA) and tetracyclic oxidize alkaloids (TOA); they are main constituents of the plant. Although U. rhynchophylla has some of these alkaloids, they are in the bark of the root and not the inner bark of the vine, which is the part of the plant used to treat Lyme disease. TOAs are especially effective in treating neurological effects of Lyme disease, while POAs improve immune function. There is some discussion around whether TOAs reduce the effect of POAs. Herbalist and Lyme authority Stephen Buhner does not support this claim. There are many products available, like Samento, that are TOA-free. In my experience, the traditional extraction process of U. tomentosa that includes both TOAs and POAs does not seem more or less effective than a TOA-free product.
The main side effect from using Uncaria is possible gastrointestinal discomfort. U. rhynchophylla is a hypotensive, and therefore should be used with caution if you are on antihypertensive medication. Do not use if you are pregnant, if you are trying to become pregnant, while taking anticoagulants, if you are undergoing an organ transplant, before surgery, or while you are taking immunosuppressive drugs (e.g., cyclosporin).