Age Later by Barzilai, Nir -- Read -- Imperial Library of Trantor

Index

Cover Title Page Copyright Notice Dedication Introduction One: One Hundred Years Young

The Mysteries of Aging What Makes SuperAgers Stay Healthy? Studying Centenarians Designing a Study Without a Control Group Meeting Our First AJ Centenarians and Their Offspring A Perfect Genome? Centenarians’ Interactions with Their Environments Do as I Say, Not as I Do

Two: Why We Age

Recent Theories The Search for Protection from Aging Eating Less May Lead to More Healthy Years Unlocking the Secrets in Fat Caloric Restriction: A Mixed Bag of Effects Aging Begins Before We’re Born SuperAgers’ Top Secrets

Three: Cholesterol: Is More Better?

Unlocking Cholesterol’s Longevity Secrets Are There Really Good Gene Mutations? Solving the Mystery of Helpful Gene Mutations The Benefits of CETP Personified A Mutation That Adds Years to Life Span?

Four: Growth Hormone: Less Is More

Less Growth May Lead to an Exceptionally Long Life Growth Hormone Clues from Our Centenarians Epigenetic Mechanisms Can Increase Longevity Making the Most of Our Findings Growth Hormones Don’t “Grow” Life Span

Five: Unraveling the Longevity Mystery Deep Inside Our Cells

A Match Made on Earth Mitochondria’s Hidden Purpose Resilient to the End A CohBar Is Born Searching for Promising Peptides

Six: The Quest to Prove Aging Can Be Targeted

Choosing an Existing Drug to Prove Our Point Getting the FDA on Board How the TAME Study Works Who’s Going to Pay for All of This? Metformin Is the Tool, Not the Goal

Seven: Making Eighty the New Sixty

The Price of Progress Collaboration Is the Key to Speed Long, Healthy Life Span Versus Immortality The Gap Between Making Drugs and Making Drugs Available

Eight: Stop the Clock

How Old Is Old? Use It or Lose It Antioxidants and Hormesis Thriving in the Shadow of Stress Preventing the Loss of Muscle Mass as We Age Exercise Plus Metformin Feeding Our Longevity Hydrating Wisely Prevent Obesity Nutraceuticals Are in the Works The Magic Pills We’ve Been Wishing For When We Eat Matters Our DNA Has Something to Say Stay Mentally Sharp Other Promising Practices How to Decide What’s Good for You

Nine: Bright Horizons

The Unparalleled Power of Omics Personalized Medicine Advances in Early Detection Pioneering Explorations Reversing Cellular Age Genetic Engineering

Acknowledgments Index About the Author Newsletter Sign-up Contents Copyright