Chapter 1: Inflammation and Oxidation in Aging and Chronic Diseases
1.2 EXPERIMENTAL MODELS FOR AGING
1.4 BYSTANDER DAMAGE AND DEPENDENT VARIABLES IN SENESCENCE
1.5 ARTERIAL AGING AND ATHEROSCLEROSIS
1.6 ALZHEIMER DISEASE AND VASCULAR-RELATED DEMENTIAS
1.8 PROCESSES OF NORMAL AGING IN THE ABSENCE OF SPECIFIC DISEASES
Chapter 2: Infections, Inflammogens, and Drugs
2.3 INFECTIONS FROM THE CENTRAL TUBE: METCHNIKOFF REVISITED
2.4 AEROSOLS AND DIETARY INFLAMMOGENS
2.5 INFECTIONS, INFLAMMATION, AND LIFE SPAN
2.6 ARE INFECTIONS A CAUSE OF OBESITY?
2.7 INFLAMMATION, DEMENTIA, AND COGNITIVE DECLINE
2.8 IMMUNOSENESCENCE AND STEM CELLS
2.9 CANCER, INFECTION, AND INFLAMMATION
2.10 PHARMACOPLEIOTROPIES IN VASCULAR DISEASE, DEMENTIA, AND CANCER
Chapter 3: Energy Balance, Inflammation, and Aging
3.2 DIET RESTRICTION AND AGING
3.3 ENERGY SENSING IN DIET RESTRICTION AND SATIETY
3.4 EXERCISE, CARDIOVASCULAR HEALTH, AND LONGEVITY
3.5 DIET, EXERCISE, AND NEURODEGENERATION
3.6 LABORATORY RODENTS AS MODELS FOR THE ‘COUCH POTATO’
3.7 ENERGY BALANCE IN THE LIFE HISTORY
Chapter 4: Nutrition and Infection in the Developmental Influences on Aging
4.2 SYNOPSIS OF THE FETAL ORIGINS THEORY
4.3 THE BARKER STUDIES OF INFECTIONS AND VASCULAR DISEASE
4.4 SIZE, HEALTH, AND LONGEVITY
4.5 INFECTION AND UNDERNUTRITION ON BIRTH WEIGHT AND LATER DISEASE
4.6 INFECTION AND NUTRITION IN POSTNATAL DEVELOPMENT AND LATER DISEASE
4.8 MATERNAL PHYSIOLOGY, FETAL GROWTH, AND LATER CHRONIC DISEASE
4.9 GROWTH IN ADAPTIVE RESPONSES TO THE ENVIRONMENT
4.10 GENOMICS OF FETAL GROWTH REGULATION
5.2 SOURCES OF INDIVIDUAL VARIATIONS IN AGING AND LIFE SPAN
5.3 SEX DIFFERENCES IN LONGEVITY
5.4 METABOLISM AND HOST-DEFENSE IN WORM AND FLY
Chapter 6: The Human Life Span: Present, Past, and Future
6.3 FOUR MAJOR SHIFTS IN HUMAN LIFE HISTORY FROM GENETIC AND CULTURAL EVOLUTION
6.4 THE INSTABILITY OF LIFE SPANS
6.5 SUMMARY OF CHAPTERS 1–6: MECHANISMS IN AGING AND LIFE HISTORY EVOLUTION