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Foreword by Robert Freedman
Acknowledgments |
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Introduction
Alan S. Brown and Paul H. Patterson |
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Overview
Schizophrenia and the Lifetime Trajectory of Psychotic Illness: Developmental Neuroscience and Pathobiology, Redux
John L. Waddington, Robin J. Hennessy, Colm M. P. O’Tuathaigh, Olabisi Owoeye, and Vincent Russell |
| PART 1 |
Clinical Research on Risk Factors for Schizophrenia |
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SECTION 1
Environmental Factors: Epidemiologic Studies on the Etiologies of Schizophrenia |
| 1 |
Maternal Infection and Schizophrenia
Alan S. Brown |
| 2 |
Prenatal Nutrition and the Etiology of Schizophrenia
Kristin N. Harper and Alan S. Brown |
| 3 |
Obstetric Complications and Schizophrenia:
Historical Overview and New Directions
Mary Clarke, Sarah Roddy, and Mary Cannon |
| 4 |
Maternal Stress During Pregnancy and Schizophrenia
Mary C. Iampietro and Lauren M. Ellman |
| 5 |
Advancing Paternal Age and the Risk for Schizophrenia
Sarah Crystal, Karine Kleinhaus, Mary Perrin, and Dolores Malaspina |
| 6 |
Cannabis Use as a Component Cause of Schizophrenia
Paola Casadio, Marta Di Forti, and Robin M. Murray |
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SECTION 2
Genetics and Epigenetics |
| 7 |
Schizophrenia Genetics: What Have We Learned from Genomewide Association Studies?
Alan R. Sanders, Jubao Duan, and Pablo V. Gejman |
| 8 |
Genetic Architecture of Schizophrenia:
The Contribution of Copy Number Variation
Maria Karayiorgou, Rebecca J. Levy, and Bin Xu |
| 9 |
The Epigenetics of Schizophrenia
Iris Cheung, Mira Jakovcevski, and Schahram Akbarian |
| PART 2 |
Preclinical Research on Etiologies of Schizophrenia |
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SECTION 1
Animal Models of Environmental Factors and Schizophrenia |
| 10 |
Animal Models of the Maternal Infection Risk Factor for Schizophrenia
Paul H. Patterson |
| 11 |
Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia
Xiaoying Cui, Darryl W. Eyles, Thomas H. J. Burne, and John J. McGrath |
| 12 |
Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia
Lisa M. Tarantino, Teresa M. Reyes, and Abraham A. Palmer |
| 13 |
Animal Models of the Maternal Stress Risk Factor for Schizophrenia
Paul H. Patterson |
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SECTION 2
Animal Models of Genetic Factors and Schizophrenia |
| 14 |
DISC1: A New Paradigm for Schizophrenia and Biological Psychiatry
David Porteous |
| 15 |
Mutant Models of Nrg1 and ErbB4:
Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia
Yachi Chen, Lorna W. Role, and David A. Talmage |
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List of Contributors
Index |