CONTENTS

Preface

Contributors

SECTION I

INTRODUCTION TO BASIC NEUROSCIENCE

Eric J. Nestler

1. OVERVIEW OF BRAIN DEVELOPMENT

John L. R. Rubenstein

2. NEUROCHEMICAL SYSTEMS IN THE CENTRAL NERVOUS SYSTEM

Ariel Y. Deutch and Robert H. Roth

3. PRINCIPLES OF ELECTROPHYSIOLOGY

Evelyn K. Lambe

4. PRINCIPLES OF SIGNAL TRANSDUCTION

Jean-Antoine Girault and Paul Greengard

5. SYNAPTIC AND NEURAL PLASTICITY

Saïd Kourrich and Antonello Bonci

6. PRINCIPLES OF MOLECULAR BIOLOGY

Steven E. Hyman and Eric J. Nestler

7. EPIGENETICS OF PSYCHIATRIC DISEASES

Bryan E. McGill and Huda Y. Zoghbi

SECTION II

NEW METHODS AND NEW TECHNOLOGIES FOR PRECLINICAL AND CLINICAL NEUROBIOLOGY

Karl Deisseroth

8. TRANSGENIC TOOLS AND ANIMAL MODELS OF MENTAL ILLNESS

Lisa M. Monteggia, William A. Carlezon, Jr., and Ralph J. DiLeone

9. APPLICATION OF STEM CELLS TO UNDERSTANDING PSYCHIATRIC DISORDERS

Kimberly M. Christian, Hongjun Song, and Guo-li Ming

10. OPTOGENETIC TECHNOLOGIES FOR PSYCHIATRIC DISEASE RESEARCH: CURRENT STATUS AND CHALLENGES

Lief E. Fenno and Karl Deisseroth

11. BLOOD–BRAIN BARRIER OPENING AND DRUG DELIVERY USING FOCUSED ULTRASOUND AND MICROBUBBLES

Elisa E. Konofagou

12. GENETIC METHODOLOGIES AND APPLICATIONS

Shaun M. Purcell

13. THE BRAIN AND ITS EPIGENOME

Amanda C. Mitchell, Yan Jiang, Cyril J. Peter, Ki A. Goosens, and Schahram Akbarian

14. NETWORK METHODS FOR ELUCIDATING THE COMPLEXITY OF COMMON HUMAN DISEASES

Eric E. Schadt

15. BRAIN IMAGING METHODOLOGIES

Hanzhang Lu, Yihong Yang, and Peiying Liu

16. IMAGE-GUIDED BRAIN STIMULATION

Mark S. George, Joseph J. Taylor, and Jaimie M. Henderson

SECTION III

PSYCHOTIC DISORDERS

Pamela Sklar

17. DIAGNOSIS OF THE PSYCHOSES

Lianne Morris Smith, Julie W. Messinger, and Dolores Malaspina

18. GENETICS OF SCHIZOPHRENIA AND BIPOLAR DISORDER

Pamela Sklar

19. GENOMIC SYNDROMES IN SCHIZOPHRENIA: OVERLAPPING PHENOTYPES

George Kirov, Michael C. O’Donovan, and Michael J. Owen

20. NEUROIMAGING OF PSYCHOTIC DISORDERS

Stephan Heckers, Neil Woodward, and Dost Öngür

21. COGNITIVE AND MOTIVATIONAL NEUROSCIENCE OF PSYCHOTIC DISORDERS

Alan Anticevic, Erin C. Dowd, and Deanna M. Barch

22. MOUSE MODELS OF SCHIZOPHRENIA AND BIPOLAR DISORDER

Mikhail V. Pletnikov and Christopher A. Ross

23. CORTICAL GABA NEURONS IN SCHIZOPHRENIA

Allison A. Curley and David A. Lewis

24. SYNAPTIC DISEASE IN PSYCHIATRY

Seth G. N. Grant

25. NEURODEVELOPMENT AND SCHIZOPHRENIA

Ester J. Kwon, Takahiro Soda, and Li-Huei Tsai

26. NEUROBIOLOGY OF MENTAL ILLNESS PSYCHOSIS PRONENESS

Raquel E. Gur

27. PSYCHOTIC DISORDERS: NEUROCHEMISTRY AND PHARMACOTHERAPY

Carol A. Tamminga and Elena I. Ivleva

28. THE NEUROBIOLOGY OF BIPOLAR DISORDER

Katherine E. Burdick , Stephen J. Haggarty, and Roy Perlis

SECTION IV

MOOD DISORDERS

Helen S. Mayberg

29. THE DIAGNOSIS OF MOOD DISORDERS

Jan Fawcett and Brant Hager

30. GENETICS OF DEPRESSION

Douglas F. Levinson

31. ANIMAL MODELS OF MOOD DISORDERS

Georgia E. Hodes and Scott J. Russo

32. MOLECULAR AND CELLULAR PATHOGENESIS OF DEPRESSION AND MECHANISMS FOR TREATMENT RESPONSE

Ronald S. Duman

33. PATHOGENESIS OF DEPRESSION: CLINICAL STUDIES

Maura A. Furey, Daniel C. Mathews, and Carlos A. Zarate Jr.

34. NEURAL CIRCUITRY OF DEPRESSION

Joseph L. Price and Wayne C. Drevets

35. NEUROBIOLOGY OF DEPRESSION IN LATER LIFE: ANATOMY OF MELANCHOLIA

K. Ranga Rama Krishnan

36. GONADAL STEROIDS AND MOOD DISORDERS

David R. Rubinow, Peter J. Schmidt, and Claire D. Craft

37. DEPRESSION AND MEDICAL ILLNESS

Tami D. Benton, Joshua Blume, Paul Crits-Christoph, Benoit Dubé, and Dwight L. Evans

38. TREATMENTS FOR DEPRESSION

Dan V. Iosifescu, James W. Murrough, and Dennis S. Charney

SECTION V

ANXIETY DISORDERS

Kerry J. Ressler

39. DIAGNOSIS OF ANXIETY DISORDERS

Meghan E. Keough, Murray B. Stein, and Peter P. Roy-Byrne

40. GENETICS OF ANXIETY DISORDERS

Javier A. Perez, Takeshi Otowa, Roxann Roberson-Nay, and John M. Hettema

41. NEUROBIOLOGY OF FEAR AND ANXIETY: CONTRIBUTIONS OF ANIMAL MODELS TO CURRENT UNDERSTANDING

Christopher K. Cain, Gregory M. Sullivan, and Joseph E. LeDoux

42. DIFFERENTIAL ROLES OF GABA RECEPTORS IN ANXIETY

Hanns Möhler

43. PREFRONTAL CORTEX REGULATION OF EMOTION AND ANXIETY

Bronwyn M. Graham and Mohammed R. Milad

44. DEVELOPMENTAL COMPONENTS OF FEAR AND ANXIETY IN ANIMAL MODELS

Siobhan S. Pattwell, Anne-Marie Mouly, Regina M. Sullivan, and Francis S. Lee

45. FUNCTIONAL NEUROCIRCUITRY AND NEUROIMAGING STUDIES OF ANXIETY DISORDERS

Madeleine S. Goodkind, Anett Gyurak, and Amit Etkin

46. NOVEL TREATMENT APPROACHES FOR ANXIETY DISORDERS

Anita Van Zwieten, Gail A. Alvares, and Adam J. Guastella

47. PHARMACOTHERAPY OF ANXIETY DISORDERS

James W. Murrough, Dan V. Iosifescu, and Dennis S. Charney

48. NEUROBIOLOGY AND TREATMENT OF OCD

Susanne E. Ahmari and H. Blair Simpson

49. NEUROBIOLOGY AND TREATMENT OF PTSD

Karen E. Murray, Orion P. Keifer Jr., Kerry J. Ressler, Seth Davin Norrholm, and Tanja Jovanovic

SECTION VI

SUBSTANCE USE DISORDERS

Antonello Bonci and Nora D. Volkow

50. ANIMAL MODELS OF ADDICTION

Rafael Maldonado, J. David Jentsch, Brigitte L. Kieffer, and Christopher J. Evans

51. CELLULAR AND MOLECULAR MECHANISMS OF ADDICTION

Kathryn J. Reissner and Peter W. Kalivas

52. THE GENETIC BASIS OF ADDICTIVE DISORDERS

David Goldman

53. BRAIN DEVELOPMENT AND THE RISK FOR SUBSTANCE ABUSE

Kristina Caudle and B.J. Casey

54. MOLECULAR IMAGING IN ADDICTIVE DISORDERS

Chelsea L. Robertson, Steven M. Berman, and Edythe D. London

55. BRAIN, REWARD, AND DRUG ADDICTION

Vani Pariyadath, Martin P. Paulus, and Elliot A. Stein

56. MAGNETIC RESONANCE SPECTROSCOPY STUDIES IN SUBSTANCE ABUSERS

Linda Chang, Christine C. Cloak, and John L. Holt

57. PHARMACOTHERAPY OF SUBSTANCE USE DISORDERS

Jane B. Acri and Phil Skolnick

58. EPIDEMIOLOGY OF SUBSTANCE USE DISORDERS

Denise B. Kandel, Mei-Chen Hu, and Pamela C. Griesler

SECTION VII

DEMENTIA

David M. Holtzman

59. CLINICAL AND NEUROPSYCHOLOGICAL FEATURES OF ALZHEIMER’S DISEASE

Jason Hassenstab, Jeffrey Burns, and John C. Morris

60. THE GENETICS OF ALZHEIMER’S DISEASE

Rudolph E. Tanzi

61. EXPERIMENTAL ANIMAL MODELS OF ALZHEIMER’S DISEASE

Dave Morgan

62. STRUCTURAL, FUNCTIONAL, AND MOLECULAR NEUROIMAGING BIOMARKERS FOR ALZHEIMER’S DISEASE

James B. Brewer, Jorge Sepulcre, and Keith A. Johnson

63. FLUID BIOMARKERS FOR ALZHEIMER’S DISEASE

Anne M. Fagan

64. CURRENT THERAPIES FOR ALZHEIMER’S DISEASE

Mary Sano and Judith Neugroschl

65. DISEASE-MODIFYING THERAPIES FOR ALZHEIMER’S DISEASE

Joshua D. Grill and Jeffrey Cummings

66. LEWY BODY DEMENTIAS

Stella Karantzoulis and James E. Galvin

67. CLINICAL FEATURES AND PATHOGENESIS OF FRONTOTEMPORAL DEMENTIA

Georges Naasan and Bruce Miller

68. PATHOGENESIS, DIAGNOSIS, AND TREATMENT OF VASCULAR AND MIXED DEMENTIAS

Helena Chang Chui

69. CLINICAL FEATURES AND PATHOGENESIS OF PRION DISEASE

Joel C. Watts and Michael D. Geschwind

SECTION VIII

PSYCHIATRIC DISORDERS OF CHILDHOOD ONSET

Joseph D. Buxbaum

70. EPIDEMIOLOGY OF NEUROPSYCHIATRIC AND DEVELOPMENTAL DISORDERS OF CHILDHOOD

Elise B. Robinson, Benjamin M. Neale, and Mark J. Daly

71. RARE VARIANTS OF SUBSTANTIAL EFFECT IN PSYCHIATRIC DISORDERS OF CHILDHOOD ONSET

Heather C. Mefford

72. EPIGENETICS IN EARLY LIFE PROGRAMMING

Tracy L. Bale

73. ANIMAL MODELS IN PSYCHIATRIC DISORDERS OF CHILDHOOD ONSET

Richard Paylor, Alexia M. Thomas, Surabi Veeraragavan, and Shannon M. Hamilton

74. NEUROPATHOLOGY AND SYNAPTIC ALTERATIONS IN NEURODEVELOPMENTAL DISORDERS

Mara Dierssen and Salvador Martínez

75. FUNCTIONAL CONNECTIVITY: APPLICATION TO DEVELOPMENTAL DISORDERS

Luke Bloy, Ragini Verma, and Timothy P. L. Roberts

76. INTELLECTUAL DISABILITY SYNDROMES

Charles E. Schwartz, Fiorella Gurrieri, and Giovanni Neri

77. AUTISM SPECTRUM DISORDERS

Alexander Kolevzon, A. Ting Wang, David Grodberg, and Joseph D. Buxbaum

78. NEUROBIOLOGY OF ATTENTION DEFICIT/HYPERACTIVITY DISORDER

Stephen V. Faraone and Joseph Biederman

79. TOURETTE SYNDROME AND TIC DISORDERS

Kyle Williams, Michael H. Bloch, Matthew W. State, and Christopher Pittenger

80. NOVEL THERAPEUTICS IN CHILDHOOD ONSET PSYCHIATRIC DISORDERS

Dorothy E. Grice, Alexander Kolevzon, Walter E. Kaufmann, and Joseph D. Buxbaum

SECTION IX

SPECIAL TOPIC AREAS

Dennis S. Charney

81. DSM-5 OVERVIEW AND GOALS

David J. Kupfer and Susan K. Schultz

82. THE INFIRMITIES OF PSYCHIATRIC DIAGNOSIS

Steven E. Hyman

83. TOWARD PRECISION MEDICINE IN PSYCHIATRY: THE NIMH RESEARCH DOMAIN CRITERIA PROJECT

Bruce N. Cuthbert and Thomas R. Insel

84. THE NEUROBIOLOGY OF PERSONALITY DISORDERS: THE SHIFT TO DSM-5

M. Mercedes Perez-Rodriguez, Antonia S. New, and Larry J. Siever

85. THE NEUROBIOLOGY OF AGGRESSION

R. James R. Blair

86. THE NEUROBIOLOGY OF SOCIAL ATTACHMENT

Adam S. Smith, Kelly Lei, and Zuoxin Wang

87. THE NEUROBIOLOGY OF SLEEP

Giulio Tononi and Chiara Cirelli

88. THE NEUROBIOLOGY OF RESILIENCE

Adriana Feder, Margaret Haglund, Gang Wu, Steven M. Southwick, and Dennis S. Charney

89. THE NEUROBIOLOGY OF EATING DISORDERS

Thomas B. Hildebrandt and Amanda Downey

Index